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Marc van de Wetering

Hubrecht Institute for Developmental Biology and Stem Cell Research

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Hans Clevers

University Medical Center Utrecht

Frank C. P. Holstege

University Medical Center Utrecht

Thanasis Margaritis

Princess Máxima Center

Margit Bleijs

Princess Máxima Center

Lindy L. Visser

Oncode Institute

David Hume

University of Queensland

Naganari Ohkura

Osaka University

Alan J. Knox

University of Nottingham

Juha Kere

University of Helsinki

Yuki I. Kawamura

National Center for Global Health and Medicine

Cooperative Institutions

University Medical Center Utrecht

Utrecht University

Oncode Institute

Weatherford College

Hubrecht Institute for Developmental Biology and Stem Cell Research

RIKEN Center for Integrative Medical Sciences

Heidelberg University

Princess Máxima Center

Royal Netherlands Academy of Arts and Sciences

Cancer Genomics Centre

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Research Field

TCF/LEF factors earn their wings

Trends in Genetics (1997)

Hans Clevers Marc van de Wetering

Adenomatous polyposis coli

10.1016/s0168-9525(97)01305-x

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Citations (288)

Supplementary Table 3 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

Lindy L. Visser Margit Bleijs Thanasis Margaritis Marc van de Wetering Frank C. P. Holstege

<p>Cell-cell interaction output T/NK vs. myeloid cells</p>

Table (database)

10.1158/2767-9764.24428328.v1

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Supplementary Table 2 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

Lindy L. Visser Margit Bleijs Thanasis Margaritis Marc van de Wetering Frank C. P. Holstege

<p>Interactions literature references</p>

Table (database)

10.1158/2767-9764.24428331.v1

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Supplementary Figure S5 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

Lindy L. Visser Margit Bleijs Thanasis Margaritis Marc van de Wetering Frank C. P. Holstege

<p>Immune cell landscape of Ewing sarcoma</p>

Ewing's sarcoma

10.1158/2767-9764.24428349.v1

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Supplementary Figure S9 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

Lindy L. Visser Margit Bleijs Thanasis Margaritis Marc van de Wetering Frank C. P. Holstege

<p>Predicted cell-cell interactions in the Ewing sarcoma microenvironment</p>

Ewing's sarcoma

10.1158/2767-9764.24428337

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Genome sequencing of normal cells reveals developmental lineages and mutational processes

Sam Behjati Meritxell Huch Ruben van Boxtel Wouter R. Karthaus David C. Wedge

Multicellular organism

Lineage (genetic)

10.1038/nature13448

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Citations (345)

OLFM4 Is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells

Gastroenterology (2009)

Laurens G. van der Flier Andrea Haegebarth Daniel E. Stange Marc van de Wetering Hans Clevers

10.1053/j.gastro.2009.05.035

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Citations (498)

Sequence-specific High Mobility Group Box Factors Recognize 10–12-Base Pair Minor Groove Motifs

Journal of Biological Chemistry (2000)

Moniek van Beest Dennis Dooijes Marc van de Wetering Søren Kjærulff Alexandre M. J. J. Bonvin

Sequence-specific high mobility group (HMG) box factors bind and bend DNA via interactions in the minor groove. Three-dimensional NMR analyses have provided the structural basis for this interaction. The cognate HMG domain DNA motif is generally believed to span 6–8 bases. However, alignment of promoter elements controlled by the yeast genes ste11 andRox1 has indicated strict conservation of a larger DNA motif. By site selection, we identify a highly specific 12-base pair motif for Ste11, AGAACAAAGAAA. Similarly, we show that Tcf1, MatMc, and Sox4 bind unique, highly specific DNA motifs of 12, 12, and 10 base pairs, respectively. Footprinting with a deletion mutant of Ste11 reveals a novel interaction between the 3′ base pairs of the extended DNA motif and amino acids C-terminal to the HMG domain. The sequence-specific interaction of Ste11 with these 3′ base pairs contributes significantly to binding and bending of the DNA motif.

Base (topology)

Sequence (biology)

Groove (engineering)

High-mobility group

10.1016/s0021-9258(19)61506-1

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Citations (96)

Journal of Biological Chemistry (1993)

Leo Van Houte Annemiek Van Oers Marc van de Wetering Dennis Dooijes Rob Kaptein

Nonenzymatic glycation alters protein

10.1016/s0021-9258(17)46857-8

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assay information of the human timecourse samples for HeliScopeCAGE

Figshare (2017)

Hans Clevers Albert S.B. Edge Marc van de Wetering Michael Detmar Haruhiko Koseki

a tab delimited flat file (SDRF file) describing the experimental details for human timecourse samples for the standard protocol of the HeliScopeCAGE protocol

10.6084/m9.figshare.c.3728767_d8

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