Priten Vora

University of California, Los Angeles

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i-10 index

Research Trends

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Document Type

Co-Authors

Arpana Gupta

University of California, Los Angeles

Emeran A. Mayer

University of California, Los Angeles

Tien S. Dong

University of California, Los Angeles

Ravi R. Bhatt

University of Southern California

Jennifer S. Labus

University of California, Los Angeles

Jean Stains

University of California, Los Angeles

Bruce D. Naliboff

University of California, Los Angeles

Xiaoyue Cathy Liu

University of Utah

Vadim Osadchiy

University of California, Los Angeles

Jonathan P. Jacobs

University of California, Los Angeles

Cooperative Institutions

University of California, Los Angeles

Center for Neurologic Study

UCLA Health

University of Southern California

Centre For Digestive Diseases

Harvard University

VA Greater Los Angeles Healthcare System

Center for Digestive and Liver Diseases

UCLA Medical Center

Indiana University School of Medicine

Author Statistics

Papers

Citation

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Research Field

Mo1567 DIFFERENCES IN BRAIN STRUCTURE PREDICT SYMPTOM IMPROVEMENT IN FEMALES WITH IRRITABLE BOWEL SYNDROME

Gastroenterology (2020)

Ravi R. Bhatt Arpana Gupta Cathy Liu Jean Stains Priten Vora

10.1016/s0016-5085(20)32932-2

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Citations (0)

323 STRESS-RESILIENCE IMPACTS PSYCHOLOGICAL WELLBEING: EVIDENCE FROM BRAIN-GUT MICROBIOME INTERACTIONS

Gastroenterology (2024)

Desiree Delgadillo Eric An Jennifer Yang Rishabh Agarwal Jennifer S. Labus

Resilience

Gut microbiome

Psychological stress

10.1016/s0016-5085(24)00661-9

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Citations (0)

149: HOW DISCRIMINATION GETS UNDER THE SKIN: BIOLOGICAL DYSREGULATION OF THE BRAIN-GUT-MICROBIOME-IMMUNE SYSTEM IN DIVERSE RACIAL GROUPS

Gastroenterology (2022)

Tien S. Dong Gilbert C. Gee Emeran A. Mayer Hiram Beltrán‐Sánchez May D. Wang

Immune Dysregulation

Gut microbiome

10.1016/s0016-5085(22)60065-9

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Citations (0)

Tu1600: EARLY LIFE ADVERSITY IMPACTS ALTERATIONS IN BRAIN STRUCTURE AND FOOD ADDICTION IN OBESE INDIVIDUALS

Gastroenterology (2022)

Jennifer S. Labus Emeran A. Mayer Tien S. Dong Cathy Liu Priten Vora

Food addiction

10.1016/s0016-5085(22)62433-8

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Citations (0)

Machine learning model to predict obesity using gut metabolite and brain microstructure data

Scientific Reports (2023)

Vadim Osadchiy Roshan Bal Emeran A. Mayer Rama Kunapuli Tien S. Dong

Abstract A growing body of preclinical and clinical literature suggests that brain-gut-microbiota interactions may contribute to obesity pathogenesis. In this study, we use a machine learning approach to leverage the enormous amount of microstructural neuroimaging and fecal metabolomic data to better understand key drivers of the obese compared to overweight phenotype. Our findings reveal that although gut-derived factors play a role in this distinction, it is primarily brain-directed changes that differentiate obese from overweight individuals. Of the key gut metabolites that emerged from our model, many are likely at least in part derived or influenced by the gut-microbiota, including some amino-acid derivatives. Remarkably, key regions outside of the central nervous system extended reward network emerged as important differentiators, suggesting a role for previously unexplored neural pathways in the pathogenesis of obesity.

Leverage (statistics)

Gut–brain axis

10.1038/s41598-023-32713-2

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Citations (12)

Mo1157 DIFFERENCES IN BRAIN SIGNATURES IN ULCERATIVE COLITIS AND IRRITABLE BOWEL SYNDROME

Gastroenterology (2020)

Joanna Turkiewicz Ravi R. Bhatt Beatrix Krause Priten Vora Arpana Gupta

10.1016/s0016-5085(20)32698-6

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Citations (1)

734 BRAIN-GUT-MICROBIOME DIFFERENCES BETWEEN CONSTIPATION-PREDOMINANT VS. NON-CONSTIPATION-PREDOMINANT IBS

Gastroenterology (2021)

Rachel P. Sarnoff Emeran A. Mayer Vadim Osadchiy Zixi Chen Vishvak Subramanyam

Gut microbiome

Gut–brain axis

10.1016/s0016-5085(21)01107-0

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Citations (0)

Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain’s reward center

Gut Microbes (2022)

Tien S. Dong Michelle Guan Emeran A. Mayer Jean Stains Xiaoyue Cathy Liu

The prevalence of obesity has risen to its highest values over the last two decades. While many studies have either shown brain or microbiome connections to obesity, few have attempted to analyze the brain-gut-microbiome relationship in a large cohort adjusting for cofounders. Therefore, we aim to explore the connection of the brain-gut-microbiome axis to obesity controlling for such cofounders as sex, race, and diet. Whole brain resting state functional MRI was acquired, and connectivity and brain network properties were calculated. Fecal samples were obtained from 287 obese and non-obese participants (males n = 99, females n = 198) for 16s rRNA profiling and fecal metabolites, along with a validated dietary questionnaire. Obesity was associated with alterations in the brain's reward network (nucleus accumbens, brainstem). Microbial diversity (p = .03) and composition (p = .03) differed by obesity independent of sex, race, or diet. Obesity was associated with an increase in

Gut microbiome

Gut–brain axis

Prevotella

Signature (topology)

Center (category theory)

10.1080/19490976.2022.2051999

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Citations (49)

660: A BRAIN-GUT MICROBIOME SIGNATURE DEPENDENT ON PHYSICALACTIVITY CONTRIBUTES TO IMPROVED RESILIENCE, COPING, AND FOOD ADDICTION IN AN OBESE POPULATION

Gastroenterology (2022)

Michelle Guan Tien S. Dong Zixi Chen Vishvak Subramanyam Yurui Zhang

Gut microbiome

Resilience

10.1016/s0016-5085(22)60391-3

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Citations (0)

Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women

Nutrients (2020)

Tien S. Dong Arpana Gupta Jonathan P. Jacobs Venu Lagishetty Elizabeth Gallagher

Background: Bariatric surgery is proven to change eating behavior and cause sustained weight loss, yet the exact mechanisms underlying these changes are not clearly understood. We explore this in a novel way by examining how bariatric surgery affects the brain–gut–microbiome (BGM) axis. Methods: Patient demographics, serum, stool, eating behavior questionnaires, and brain magnetic resonance imaging (MRI) were collected before and 6 months after laparoscopic sleeve gastrectomy (LSG). Differences in eating behavior and brain morphology and resting-state functional connectivity in core reward regions were correlated with serum metabolite and 16S microbiome data. Results: LSG resulted in significant weight loss and improvement in maladaptive eating behaviors as measured by the Yale Food Addiction Scale (YFAS). Brain imaging showed a significant increase in brain volume of the putamen (p.adj < 0.05) and amygdala (p.adj < 0.05) after surgery. Resting-state connectivity between the precuneus and the putamen was significantly reduced after LSG (p.adj = 0.046). This change was associated with YFAS symptom count. Bacteroides, Ruminococcus, and Holdemanella were associated with reduced connectivity between these areas. Metabolomic profiles showed a positive correlation between this brain connection and a phosphatidylcholine metabolite. Conclusion: Bariatric surgery modulates brain networks that affect eating behavior, potentially through effects on the gut microbiota and its metabolites.

Sleeve gastrectomy

Gut microbiome

Gut–brain axis

10.3390/nu12102924

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Citations (30)