Journal Article Electrophysiologic and clinical effects of intravenous and oral encainide in patients with Wolff-Parkinson-White syndrome and paroxysmal atrial fibrillation Get access M. CHIMIENTI, M. CHIMIENTI Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Address for correspondence- Dr M. Chimienti, Divisions di Cardiol-ogia, Polichnico S. Mattco, 27100 Pavia, Italy. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. MOIZI, M. MOIZI Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar J. A. SALERNO, J. A. SALERNO Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar C. KLERSY, C. KLERSY Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar L. GUASTI, L. GUASTI Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar M. PREVITALI, M. PREVITALI Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar E. MARANGONI, E. MARANGONI Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar C. MONTEMARTINI, C. MONTEMARTINI Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar P. BOBBA P. BOBBA Section of Cardiology, Department of Internal Medicine, University of Pavia, and Division of CardiologyI.R.C.C.S. San Matteo Hospital. Pavia, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar European Heart Journal, Volume 8, Issue 3, March 1987, Pages 282–290, https://doi.org/10.1093/oxfordjournals.eurheartj.a062271 Published: 01 March 1987 Article history Received: 04 March 1986 Revision received: 26 August 1986 Published: 01 March 1987
This randomized, double-blind, placebo-controlled, multicenter trial compared the effects of treatment with ibopamine with those of placebo in patients with severe heart failure who still showed symptoms although they were receiving standard therapy with digitalis and diuretics. The results showed a significant and sustained improvement in exercise tolerance (+ 70% about in average), clinical condition, and NYHA functional class and a decrease in cardiothoracic ratio and left ventricular end-systolic wall stress in patients treated with ibopamine. digitalis, and diuretics (group 1) compared with patients treated with digitalis, diuretics, and placebo (group 2).
This randomized, double-blind, placebo-controlled, multicenter trial compared the effects of treatment with ibopamine with those of placebo in patients with severe heart failure who still showed symptoms although they were receiving standard therapy with digitalis and diuretics. The results showed a significant and sustained improvement in exercise tolerance (+70% about in average), clinical condition, and NYHA functional class and a decrease in cardiothoracic ratio and left ventricular end-systolic wall stress in patients treated with ibopamine, digitalis, and diuretics (group 1) compared with patients treated with digitalis, diuretics, and placebo (group 2).
