Amira Mohammed Abdelfattah

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Diacerein ameliorates cholestasis-induced liver fibrosis in rat via modulating HMGB1/RAGE/NF-κB/JNK pathway and endoplasmic reticulum stress

Scientific Reports (2023)

Amira Mohammed Abdelfattah Shireen S. Mahmoud Dalia Ibrahim El-wafaey Heba Mahmoud Abdelgeleel Amira Mohamed Abdelhamid

Diacerein is an interleukin (IL)-1β inhibitor approved for osteoarthritis. This study aimed to investigate the potential anti-fibrotic effect of diacerein against bile duct ligation (BDL)-induced liver fibrosis. Forty male Wistar rats were divided into: sham-operated group, BDL group, and BDL groups treated with diacerein at 10, 30, and 50 mg/kg/day starting two days before surgery and continued for 4 weeks. Diacerein decreased the hepatic injury markers and alleviated oxidative stress triggered by BDL by reducing hepatic malondialdehyde (MDA) and increasing hepatic superoxide dismutase (SOD) levels. Diacerein mitigated BDL-induced inflammation via lowering hepatic levels and mRNA expression of high mobility group box 1 (HMGB1), nuclear factor-κB (NF-κB), and IL-1β. The hepatic gene expression of Advanced Glycation End products Receptor (RAGE) gene and immunohistochemical expression of some ER stress markers, e.g., glucose-regulated protein 78 (GRP78), inositol-requiring enzyme 1 (IRE1α), protein kinase RNA-like endoplasmic reticulum kinase (PERK), CCAAT/enhancer-binding protein homologous protein (CHOP), and phosphorylated c-Jun N-terminal kinase protein contents were lowered by diacerein. Furthermore, diacerein suppressed the hepatic levels of fibrogenic mediators, e.g., Transforming growth factor β1 (TGF-β1), α- smooth muscle actin (α-SMA), collagen 1, and hydroxyproline, as well as the apoptotic caspase 3 and BAX immunostaining in BDL rats. The histopathological abnormalities induced by BDL significantly improved. Our study demonstrated that diacerein exhibited an antifibrotic effect by inhibiting HMGB1/RAGE/NF-κB/JNK pathway, and ER stress. Better protection was observed with increasing the dose.

HMGB1

RAGE

10.1038/s41598-023-38375-4

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Citations (8)

A PDE1 inhibitor, vinpocetine, ameliorates epithelial-mesenchymal transition and renal fibrosis in adenine-induced chronic kidney injury in rats by targeting the DNMT1/Klotho/β-catenin/Snail 1 and MMP-7 pathways

Naunyn-Schmiedeberg s Archives of Pharmacology (2024)

Amira Mohammed Abdelfattah Zeinab A. Mohammed Aliaa Talaat Walaa Samy Mamdouh Eldesoqui

Klotho

10.1007/s00210-024-03393-0

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Citations (0)

ON THE CHARACTERIZATION OF OUTDOOR CABLES AS DATA COMMUNICATION CHANNELS

The Egyptian International Journal of Engineering Sciences and Technology (2011)

S Aldosoky Amira Mohammed Abdelfattah A Dosouky S H Gomaa

Power Line Communication (PLC) has been considered as attractive media for high speed data transmission, particularly for applications like home networking, Internet, voice and data services.For the use of the Low Voltage networks as high speed data channel the path carrier frequencies within the range up to 30 MHz must be considered.The development of suitable communication systems and the planning of PLC networks require modeling of the transfer characteristics of the mains network in the mentioned frequency range.In this paper the considered PLC channel is North Delta Electricity Distribution Company (NDEDC) Outdoor low voltage cables, the frequency and phase responses of a three-phase power line channel with interconnections are derived.The channel transfer function is obtained and investigated using different cable lengths, and different number of branches under a given loading conditions.Loading mismatching at different branches is considered.Transfer characteristics of power line channel from distribution transformer to customer pole have been modeled using the chain matrix methodology.Simulation results indicate that there are significant attenuations and distortions as the number of branches, cable length, and load mismatching are increased.

Characterization

10.21608/eijest.2011.96668

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Citations (1)

Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress – unfolded protein response (UPR) – autophagy, and their regulatory miRNA

Life Sciences (2024)

Safaa I. Khater Mahran Mohamed Abd El-Emam Hussein Abdellatif Mahmoud Mostafa Tarek Khamis

10.1016/j.lfs.2024.122546

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Citations (5)

Vinpocetine alleviates intestinal ischemia/reperfusion injury and enhances M2 macrophage polarization in rats: Role of SIRT1/SOCS3/STAT3 signaling pathway

International Immunopharmacology (2023)