Balduíno Tschiedel

Grupo Hospitalar Conceição

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Luís Henrique Santos Canani

Hospital de Clínicas de Porto Alegre

Márcia Puñales

Sociedade Brasileira de Diabetes

Daisy Crispim

Universidade Federal do Rio Grande do Sul

Israel Roisenberg

Universidade Federal do Rio Grande do Sul

Taís Silveira Assmann

Hospital de Clínicas de Porto Alegre

Kátia Elisabete Pires Souto

Hospital Nossa Senhora da Conceição

Jorge Luiz Gross

Hospital de Clínicas de Porto Alegre

Kátia Gonçalves dos Santos

Universidade Luterana do Brasil

Luís Eduardo Calliari

Faculdade de Ciências Médicas da Santa Casa de São Paulo

Thaís Della Manna

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Cooperative Institutions

Universidade do Estado do Rio de Janeiro

Universidade Federal do Rio Grande do Sul

Hospital de Clínicas de Porto Alegre

Universidade de São Paulo

Grupo Hospitalar Conceição

Universidade Federal de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Hospital Nossa Senhora da Conceição

Sociedade Brasileira de Diabetes

University of Rio Grande and Rio Grande Community College

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Functional Vascular Endothelial Growth Factor −634G>C SNP Is Associated With Proliferative Diabetic Retinopathy

Diabetes Care (2007)

Flávia Imbroisi Valle Errera Luís Henrique Santos Canani Maria Elisabeth R. Silva Erika Yeh Walter Yukihiko Takahashi

The purpose of this study was to evaluate the effect of the single nucleotide polymorphism (SNP) -634G>C at the 5' regulatory region of the vascular endothelial growth factor (VEGF) in the risk of proliferative diabetic retinopathy (PDR) in the Brazilian population of European ancestry with type 2 diabetes.A case-control study was conducted in 501 type 2 diabetic patients of European ancestry. Patients underwent a standardized clinical, ophthalmological, and laboratory evaluation. Of these, 167 patients had PDR (case patients), and 334 were considered as control subjects (patients without PDR) for PDR. A reference population (110 individuals of European ancestry) was also evaluated.No evidence of association between -634G>C/VEGF and the presence of diabetic retinopathy or type 2 diabetes was observed (P > 0.05). However, CC homozygous for the SNP -634G>C was significantly more frequent in patients with PDR (37 of 167; 22.2%) than in the corresponding control group (40 of 334; 12%) in accordance with a recessive model (P = 0.003). This effect was further observed when creatinine, BMI, sex, duration of type 2 diabetes, HDL cholesterol, and systolic blood pressure were taken into account (odds ratio 1.9 [95% CI 1.01-3.79], P = 0.04).The presence of the allele -634C/VEGF in homozygosity is an independent risk factor for the development of PDR in type 2 diabetic patients of European ancestry.

10.2337/dc06-1399

Cite

Citations (43)

The −106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes

Molecular Genetics and Metabolism (2006)

Kátia Gonçalves dos Santos Luís Henrique Santos Canani Jorge Luiz Gross Balduíno Tschiedel Kátia Elisabete Pires Souto

10.1016/j.ymgme.2006.02.002

Cite

Citations (29)

microRNA expression profile in plasma from patients with diabetic kidney disease

Endocrine Abstracts (2017)

Taís Silveira Assmann Márcia Puñales Balduíno Tschiedel Luís Henrique Santos Canani Andréa Carla Bauer

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

10.1530/endoabs.49.gp93

Cite

Citations (0)

Punção aspirativa de tireóide com agulha fina em um hospital geral: estudo de 754 punções

Arquivos Brasileiros de Endocrinologia & Metabologia (2001)

Márcia Murussi Claudio Eduardo Farias Nunes Pereira Beatriz M.A. Assis Brasil Balduíno Tschiedel

A punção aspirativa com agulha fina (PAAF) é considerada o método diagnóstico inicial e o de melhor relação custo-benefício na avaliação da doença nodular da tireóide. Apesar das vantagens do procedimento, o sucesso do método depende da experiência do patologista e da habilidade técnica na obtenção de amostras adequadas. Neste trabalho avaliamos a eficácia do procedimento em um hospital geral de ensino. Foram realizadas 754 punções em um período de 3 anos. Cada nódulo palpável foi aspirado por médicos residentes de endocrinologia com agulha fina por 4 a 6 vezes. O material foi corado pelos métodos de Giemsa e de Papanicolaou. O resultado anatomopatológico foi obtido de 93 pacientes. A PAAF foi realizada em 663 pacientes (613F/50M), com idade média de 50±14 anos (12 a 93). Nos exames citopatológicos, os diagnósticos foram: bócio colóide (58,5%), neoplasia folicular ou suspeito (8,2%), tireoidite de Hashimoto (5,3%), carcinoma papilar (2,3%), carcinoma anaplásico (0,4%), carcinoma medular (0,1%) e insatisfatório (25,2%). Dos 93 pacientes operados, 41 (44%) apresentavam neoplasia e, entre as malignas, o carcinoma papilar foi o mais freqüente (65,6%). Na neoplasia folicular, a percentagem de carcinoma foi 24%. A análise dos dados da PAAF demonstrou: sensibilidade 92% (IC= 78,6 a 98,3%), especificidade 80% (IC= 65,4 a 90,4%), valor preditivo positivo 79,5% (IC= 64,7 a 90,2%), valor preditivo negativo 92,3% (IC= 79,1 a 98,4%) e acurácia diagnóstica 86% (IC= 76,1 a 92,3%). A PAAF estabeleceu um diagnóstico em 66,6% dos nossos pacientes, diminuindo os custos e o número de cirurgias. A taxa de detecção à cirurgia de carcinomas de tireóide aumentou de 19,4% para 31,2% em 11 anos em nosso hospital.

10.1590/s0004-27302001000600012

Cite

Citations (6)

High frequency threshold in patients with insulin-dependent diabetes mellitus [Abstract in English]

Scientia Medica (2006)

Humberto Gonçalves Reis Balduíno Tschiedel Joaquín Poch Broto

Objectives: To describe the extended high frequency threshold presents by the IDDM patients; to determinate the relation between threshold and duration of diabetes; to determinate the relation between threshold and insulin control of the patient. Material and method: 29 patients with IDDM were compared with 32 individuals of the control group. The patients were divided for duration of diabetes and the same patients were divided for insulin control too. The AC40 audiometer was utilized, with verification of conventional frequencies of 250 Hz to 8.000 Hz and, in the high frequency mode, of 9.000 Hz to 16.000 Hz. Results: The thresholds were worst for higher frequencies, which we compare it with the conventional frequencies. The frequencies of 14.000 Hz and 16.000 Hz did presents the worst thresholds for the study group and the control group too. It doesn’t found changes of statistic significance for any group, which we compare it with the control group. KEY WORDS: HEARING LOSS; AUDIOMETRY; DIABETES MELLITUS, TYPE 1; HEARING; AUDITORY THRESHOLD.

Audiometer

Source

Cite

Citations (0)

The European-Specific Mitochondrial Cluster J/T Could Confer an Increased Risk of Insulin-Resistance and Type 2 Diabetes: An Analysis of the m.4216T > C and m.4917A > G Variants

Annals of Human Genetics (2006)

Daisy Crispim Luís Henrique Santos Canani Jorge Luiz Gross Balduíno Tschiedel Kátia Elisabete Pires Souto

The aims of this study were to investigate the contributions of the mitochondrial DNA m.4216T> C and m.4917A > G variants, and also of the European-specific mitochondrial cluster J/T, to the development of type 2 diabetes mellitus in Caucasian-Brazilian patients from Southern Brazil.We analyzed 347 type 2 diabetes patients and 350 control subjects.Variant frequencies in patients and control subjects were compared using χ 2 tests or odds ratio.We also compared clinical and laboratory characteristics among patients with and without the variants.We found that the frequencies of the m.4216T > C and m.4917A > G variants are higher in diabetic patients than in control subjects.Moreover, haplogroups J (partially defined by the presence of the m.4216T > C variant only) and T (partially defined by the presence of both m.4216T > C and m.4917A > G variants) are more frequent in the type 2 diabetic group than in the control group.Patients belonging to the cluster J/T are more insulin resistant than patients of other haplogroups.In conclusion, our results indicate the association of the cluster J/T (as suggested by analyses of the m.4216T > C and m.4917A > G variants) with insulin resistance and type 2 diabetes.

10.1111/j.1529-8817.2005.00249.x

Cite

Citations (1)

Como a monitorização contínua de glicose subcutânea pode colaborar na interpretação dos valores da HbA1c no diabetes melito tipo 1?

Arquivos Brasileiros de Endocrinologia & Metabologia (2008)

Márcia Puñales César Geremia Paula Mondadori Marilisa Pickler Adriana Fornari

O objetivo desta revisão é avaliar como o sistema de monitorização contínua de glicose subcutânea (CGMS®) pode colaborar na interpretação dos valores da hemoglobina glicada (A1c) no diabetes melito tipo 1. Foi realizada uma revisão bibliográfica dos benefícios, dos métodos, da interpretação e da experiência com CGMS®. A utilização de sensores contínuos pode ser útil na avaliação de pacientes com diabetes melito com oscilações glicêmicas, hipoglicemias graves, especialmente as noturnas, e hiperglicemias pós-prandiais. A identificação de padrões glicêmicos alterados permite ajustes terapêuticos e melhora do controle metabólico. O CGMS® é um procedimento de fácil utilização, com efeitos adversos de pequena intensidade e boa tolerância pelos pacientes. Embora o fabricante preconize um período de utilização de até três dias, observa-se que o prolongamento do teste por mais dias permite a obtenção de dados que auxiliam em mudanças terapêuticas superiores às realizadas com os registros do tempo convencional.

10.1590/s0004-27302008000200017

Cite

Citations (2)

História materna de diabetes melito está associada com a presença de diabetes do tipo 2, mas não com as complicações crônicas

Rafael Selbach Scheffel Ana Luiza Krahe L.A. da Costa Luís Henrique Santos Canani Daisy Crispim

Source

Cite

Citations (0)

Insulin Injection Technique Questionnaire: results of an international study comparing Brazil, Latin America and World data

Diabetology & Metabolic Syndrome (2018)

Luís Eduardo Calliari Laura Cudizio Balduíno Tschiedel Hermelinda Cordeiro Pedrosa Rosângela Réa

In 2014-2015, the largest international survey of insulin injection technique in patients with diabetes taking insulin was conducted in 42 countries, totaling 13,289 participants. In Brazil, patients from five public health centers were included. This study aims to evaluate insulin injection technique in Brazilian patients and compare results with Latin America (LatAm) and World data.The insulin Injection Technique Questionnaire (ITQ) survey consisted of an initial patient section (questions applied by an experienced nurse), followed by observation of injection technique and examination of the injection sites by the health care professional.In Brazil, 255 patients were evaluated: 25% had type 1 diabetes mellitus (T1DM) and 75% had T2DM. In this study, 79% of patients injected less than 4 times a day, and 17.3% used insulin pens, compared to 28% in LatAm and 86% worldwide. Syringes were used by 78% of patients in Brazil, compared to 65% in LatAm and 10% globally. Differences in needle length were substantial-nearly 64% in Brazil inject with 8 mm length needle compared to 48% in LatAm and 27% worldwide. Additionally, 48% of patients in Brazil skip doses, 80% reuse pen needles and 57% reuse syringes with 27% having lipohypertrophy by exam.Brazilian patients use syringes more and pens less, inject with larger needles and have more lipohypertrophy when compared to Latin America and World data. Their re-use of needles and syringes is also high. This study showed that in Brazil, teaching of proper injection technique has to be more widespread, and more intensive during diabetes educational sessions, and the type of delivered supplies must be updated to smaller, shorter needles preferred by patients, in order to facilitate adherence to treatment. From the ITQ, we conclude that there are many aspects of insulin injection technique that may be improved in Brazil.

Insulin pen

10.1186/s13098-018-0389-3

Cite

Citations (18)

Superior Effects of High-Intensity Interval vs. Moderate-Intensity Continuous Training on Endothelial Function and Cardiorespiratory Fitness in Patients With Type 1 Diabetes: A Randomized Controlled Trial

Frontiers in Physiology (2019)

Winston Boff Antonio M. da Silva Juliano Boufleur Farinha Josianne Rodrigues‐Krause Álvaro Reischak-Oliveira

This study aimed to compare the effect of high-intensity interval training (HIIT) with moderate-intensity continuous training (MCT) on endothelial function, oxidative stress and clinical fitness in patients with type 1 diabetes. Thirty-six type 1 diabetic patients (mean age 23.5 ± 6 years) were randomized into 3 groups: HIIT, MCT, and a non-exercising group (CON). Exercise was performed in a stationary cycle ergometers during 40 min, 3 times/week, for 8 weeks at 50-85% maximal heart rate (HRmax) in HIIT and 50% HRmax in MCT. Endothelial function was measured by flow-mediated dilation (FMD) [endothelium-dependent vasodilation (EDVD)], and smooth-muscle function by nitroglycerin-mediated dilation [endothelium-independent vasodilation (EIVD)]. Peak oxygen consumption (VO2peak) and oxidative stress markers were determined before and after training. Endothelial dysfunction was defined as an increase < 8% in vascular diameter after cuff release. The trial is registered at ClinicalTrials.gov, identifier: NCT03451201. Twenty-seven patients completed the 8-week protocol, 9 in each group (3 random dropouts per group). Mean baseline EDVD was similar in all groups. After training, mean absolute EDVD response improved from baseline in HIIT: + 5.5 ± 5.4%, (P = 0.0059), but remained unchanged in MCT: 0.2 ± 4.1% (P = 0.8593) and in CON: -2.6 ± 6.4% (P = 0.2635). EDVD increase was greater in HIIT vs. MCT (P = 0.0074) and CON (P = 0.0042) (ANOVA with Bonferroni). Baseline VO2peak was similar in all groups (P = 0.96). VO2peak increased 17.6% from baseline after HIIT (P = 0.0001), but only 3% after MCT (P = 0.055); no change was detected in CON (P = 0.63). EIVD was unchanged in all groups (P = 0.18). Glycemic control was similar in all groups. In patients with type 1 diabetes without microvascular complications, 8-week HIIT produced greater improvement in endothelial function and physical fitness than MCT at a similar glycemic control.

High-Intensity Interval Training

Interval training

Intensity

10.3389/fphys.2019.00450

Cite

Citations (52)