Konstantin Glebov

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ECONOMIC FEASIBILITY OF NEW CHEMOTHERAPY REGIMENS FOR TREATMENT OF TUBERCULOSIS PATIENTS WITH EXTENSIVE DRUG RESISTANCE

Tuberculosis and lung diseases (2018)

I. А. Vаsilyevа А. G. Samoylova А. В. Рудакова Lovacheva Ov Konstantin Glebov

The article presents economic feasibility evaluation for using high-priced drugs in the regimens for treatment of tuberculosis patients with extensive drug resistance. Subjects and Methods . Treatment efficiency was evaluated in 175 tuberculosis patients with extensive drug resistance, treated by four different regimens, including third line drugs and without them; the economic impact of each regimen was evaluated. Two types of pharmaco-economic analysis were used: costs – effectiveness and budget impact analysis. Results of the study . Despite the significant costs of regimens containing moxifloxacin, linezolid, and bedaquiline, the co-efficient of costs – effectiveness turned out to be the lowest. When using models for comparing costs and losses over 5 year period of XDR TB patients treatment it was found out that regimens containing moxifloxacin, linezolid and bedaquiline possessed significant economic predominance which required major investment at the initial stages of introduction, and by the end providing savings from 46.3 to 65.3% of the budget compared to the regimens without these drugs. The obtained results provide the evidence that use of regimens containing new highly effective drugs (moxifloxacin, linezolid and bedaquiline) in rational combinations with basic and reserve drugs, prescribed with consideration of drug resistance profile allow achieving the significant economic effect.

Bedaquiline

Linezolid

Regimen

10.21292/2075-1230-2018-96-6-7-14

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Citations (11)

Factors affecting the efficacy of treatment of MDR/XDR TB patients receiving bedaquiline

Tuberculosis (2019)

Anastasia Samoilova Елена Викторовна Кирьянова Oleg Shcherbakov Konstantin Glebov Anatasia Russkikh

Concomitant

Bedaquiline

Regimen

Extensively drug-resistant tuberculosis

10.1183/13993003.congress-2019.pa4627

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ASSESSMENT OF EFFECTIVENESS OF THE EMPIRIC TREATMENT REGIMEN IN TUBERCULOSIS PATIENTS SUSPECTED WITH MULTIPLE DRUG RESISTANCE IN THE RUSSIAN FEDERATION

Tuberculosis and lung diseases (2018)

С. А. Стерликов А. G. Samoylova Vadim Testov Konstantin Glebov I. А. Vаsilyevа

ОЦЕНКА РЕЗУЛЬТАТИВНОСТИ ПРИМЕНЕНИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ ЭМПИРИЧЕСКОГО РЕЖИМА ЛЕЧЕНИЯ БОЛЬНЫХ ТУБЕРКУЛЕЗОМ С ПРЕДПОЛАГАЕМОЙ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТЬЮС. А. СТЕРЛИКОВ 1 , А

Regimen

Drug resistant tuberculosis

10.21292/2075-1230-2018-96-11-28-33

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Effect of additional drug resistance of M tuberculosis in patients with Hr-TB on the efficacy of chemotherapy

Tuberculosis (2019)

Anastasia Samoilova Irina A. Burmistrova Konstantin Glebov Anna Panova Т. С. Радина

Capreomycin

Group B

10.1183/13993003.congress-2019.pa4631

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COVERAGE WITH TESTS AND FREQUENCY OF MULTIPLE/EXTENSIVE DRUG RESISTANT TUBERCULOSIS IN THE CIVILIAN HEALTH SERVICES AND PENITENTIARY SYSTEM

Tuberculosis and lung diseases (2019)

V. V. Testov С. А. Стерликов I. А. Vasilieva Yu. V. Tikhonova Konstantin Glebov

Drug resistant tuberculosis

10.21292/2075-1230-2019-97-6-67-68

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Drug resistance pattern of <i>M. tuberculosis</i> in those who developed the disease after exposure to MDR/XDR pulmonary tuberculosis

Tuberculosis and lung diseases (2020)

Konstantin Glebov V. Guseva I. A. Burmistrova Lovacheva Ov А. G. Samoylova

10.21292/2075-1230-2019-97-12-57-57

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Prevalence of tuberculosis with multiple and extensive drug resistance according to the data of Federal register of tb cases

Tuberculosis and lung diseases (2020)

V. V. Testov I. A. Vasilyeva С. А. Стерликов Igor Medvinskiy Konstantin Glebov

Drug resistant tuberculosis

10.21292/2075-1230-2019-97-12-64-66

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RANGES OF DRUG RESISTANCE OF THE PATHOGEN SENSITIVE TO RIFAMPICIN AND RESISTANT TO ISONIAZID IN PULMONARY TUBERCULOSIS PATIENTS

Tuberculosis and lung diseases (2019)

Irina A. Burmistrova А. G. Samoylova Konstantin Glebov Anna Panova Т. С. Радина

Multi drug resistant

10.21292/2075-1230-2018-96-12-63-64

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ADAPTING PORTAL DECOMPRESSION FOR ELEVATION OF EFFICACY OF PORTOSYSTEMIC SHUNTING OPERATIONS IN PORTAL HYPERTENSION

Medical Herald of the South of Russia (2016)

Yu. V. Khoronko С И Дударев Konstantin Glebov

Purpose: to improve the results of portosystemic shunting surgical interventions using of procedures of adapting portal decompression during preoperation period. Materials and Methods: the results of transjugular intrahepatic portosystemic shunt (TIPS procedure) in 113 patients were analyzed. In 60 cases the procedure of adapting portal decompression during a period 3-5 weeks using selective vasoconstrictor octreotide in complex with non-selective beta-blockers. Results: during the follow-up postoperative period in group of patients who were undergone for adapting portal decompression the restitution of clinical and laboratory data was noticed and does not increase occurrence of hepatic insufficiency in comparison with control group. Summary: using of adapting portal decompression in preoperative period before TIPS procedure in patients with complicated portal hypertension is effective for prophylaxis of making worse of hepatic insufficiency.

Shunting

10.21886/2219-8075-2016-3-100-103

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Citations (2)

Konstantin Glebov

Papers

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H-Index

i-10 index

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H-Index

i-10 index