Manolis N. Saridomichelakis

University of Thessaly

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A. F. Koutinas

Aristotle University of Thessaloniki

Leonidas Leontides

University of Thessaly

Mathios E. Mylonakis

Aristotle University of Thessaloniki

Manolis K. Chatzis

University of Thessaly

Alexander F. Koutinas

Aristotle University of Thessaloniki

Labrini V. Athanasiou

University of Thessaly

Panagiotis G. Xenoulis

Texas A&M University

A. F. KOUTINAS

University of Veterinary Medicine

ΘΠ

Θεόδωρος Πετανίδης

University of Thessaly

Dimitrios Kasabalis

University of Thessaly

Cooperative Institutions

Aristotle University of Thessaloniki

104

University of Thessaly

University of Veterinary Medicine

North Carolina State University

National School of Public Health

Telio (Norway)

National and Kapodistrian University of Athens

Development Agency of Karditsa

École Nationale Vétérinaire d'Alfort

University of Edinburgh

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An approach to erosions and ulcerations

British Small Animal Veterinary Association eBooks (2012)

Manolis N. Saridomichelakis

PLEASE NOTE A NEW 4TH EDITION HAS BEEN PUBLISHED AND IS AVAILABLE IN THE LIBRARY AND IN PRINTAn erosion is a circumscribed depressed lesion that represents a defect of the epidermis that does not penetrate the basement membrane. Erosions do not bleed and they heal without scarring. An ulcer is a deeper defect that extends into the dermis after disruption of the basement membrane. These lesions are frequently covered by crusts, they bleed easily and, at least when they involve deep dermis, they heal with the formation of a visible scar. Ideally, the differentiation between erosions and ulcers should be based on histopathology, because it may be impossible to differentiate deeper erosions from shallow ulcers during clinical examination. Nevertheless, this distinction may not be particularly helpful in the diagnostic process because the canine and feline epidermis is thin, and therefore erosions frequently evolve into ulcers, especially if they become infected or self-traumatized. Erosions and ulcers are therefore discussed collectively for the remainder of this chapter, although more severe or deeper pathological processes are generally responsible for ulcer formation. The chapter focuses on Pathophysiology; Differential diagnosis; and Clinical approach.

Epidermis (zoology)

Histopathology

10.22233/9781905319886.8

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Canine atopic dermatitis (atopy)

Journal of the Hellenic Veterinary Medical Society (2018)

Manolis N. Saridomichelakis A. F. Koutinas

Canine atopic dermatitis is a common clinical entity, characterized by pruritus due to sensitization against common enviromental allergens. It has been proven that there is strong breed predisposition. Genetically programmed dogs overproduct reaginic antibodies (IgE and/or IgGd) after their exposure to airborne allergens (dust mites, epithelia, pollens and molds) which consequently fix themselves to the mast cells of the skin. After reexposure to the same allergens these cells degranulate, with subsequent release of many pharmacologically active substances (histamine, leucotrienes, Prostaglandines etc). However, this is a rather simplistic explanation; the true pathogenesis of atopy is more complicated and still not well understood. Clinical signs first appear between 6 months and 3 years of age. Pruritus, the mainstay of atopy, can be seasonal or perennial. Skin lesions, appearing in later, are attributed to pruritus and/or to secondary complications (staphylococcal pyoderma, seborrhea, dry skin, Malassezia dermatitis). The diagnosis, based on history and clinical findings, necessitates exclusion of other pruritic skin diseases and identification of the offending allergens by using the intradermal test and/or serology (ELISA, RAST). The latter method is diagnostically inferior to intradermal skin test due to the high rate of false positive reactions. Therapeutic options include avoidance of the allergens responsible for sensitization, systemic therapy with glucocorticoids, antihistamines and essential fatty acids in various combinations, topical antipruritic therapy, hyposensitization which is the best therapeutical modality for the perennial form of the disease and management of secondary complications as well as of other concurrent allergic skin diseases, such as food and flea allergy.

Atopy

Pyoderma

10.12681/jhvms.15734

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Sensitivity of preputial and vaginal exfoliative cytological examination for diagnosis of canine leishmaniosis (Leishmania infantum)

Journal of the Hellenic Veterinary Medical Society (2017)

Labrini V. Athanasiou Manolis K. Chatzis Pagona G. Gοuletsοu Manolis N. Saridomichelakis

Aim of the study was to examine sensitivity of preputial and vaginal exfoliative cytological examination as a noninvasive alternative to lymph node, spleen and bone marrow cytology, for detection of Leishmania infantum amastigotes in dogs with leishmaniosis, as, in previous studies, the protozoa have been observed in the penis and prepuce of male dogs and in the vagina of female dogs with leishmaniosis. In total, 20 male and 18 female dogs with confirmed leishmaniosis were included inthe study. Three cytology smears were prepared from different sites of the preputial cavity of males and one smear was prepared from the anterior vagina of females. Leishmania amastigotes were not observed in these samples after microscopic examination for 20 min at 1,000× magnification. Therefore, preputial and vaginal exfoliative cytology is not recommended for routine diagnosis of canine leishmaniosis.

Preputial gland

Exfoliative cytology

Amastigote

10.12681/jhvms.15510

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The most important skin diseases of the sheep and the goat

Journal of the Hellenic Veterinary Medical Society (2018)

Nektarios D. Giadinis Manolis N. Saridomichelakis

Skin diseases of small ruminants may have an economical impact, apart from the fact that some of them can be transmitted to humans. In this review article, the most important environmental, nutritional, parasitic, bacterial, fungal, viral, immune-mediated and neoplastic skin diseases of the goat and sheep are presented, emphasising on the clinical features, the diagnosis and the treatment.

10.12681/jhvms.15666

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A retrospective study of 10 spontaneous cases of feline atopic dermatitis (1995-1997)

Journal of the Hellenic Veterinary Medical Society (2018)

Manolis N. Saridomichelakis A. F. KOUTINAS

Ten atopic cats (5 DSH, 4 Siamese, one Persian) were admitted to the Clinic of Companion Animal Medicine, Faculty of Veterinary Medicine, A.U.T., because of a seasonal (3/10) or nonseasonal (1/10) pruritic skin disease. The seasonal pattern of the clinical signs could not be established in the rest 6 cats. The presenting cutaneous syndromes were miliary dermatitis (6 cats), self- induced alopecia - hypotrichosis (5 cats), indolent ulcer (one cat), linear eosinophilic granuloma (one cat) and head and neck self - inflicted dermatitis (one cat), some appearing alone (5/10) or in various combinations (4/10). One cat had a generalized but non - lesionai pruritus. The onset of these manifestations ranged from 6 months to 8.5 years. The aeroallergens implicated by the ID skin test were Dermatophagoides farinae (9/10), D. pteronyssinus (4/10), Acarus siro (4/10), house dust, cottonseed and tree pollens (2/10) and grass and weed pollens (1/10). ID test reactions to single or multiple aeroallergens were detected in 2 and 8 cats, respectively. Although 5 of the 10 atopic cats also reacted positive to ID test with flea allergen, there was not strong evidence that flea allergic dermatitis had been coexisting in 4 of them. Other conditions associated (conjuctivitis, bronchial asthma) or not (otodectic otitis externa) with feline atopy were seen in 3 cats.

Atopy

Allergic dermatitis

Patch test

10.12681/jhvms.15724

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An update on the treatment of canine atopic dermatitis

The Veterinary Journal (2015)

Manolis N. Saridomichelakis Thierry Olivry

Hypoallergenic

10.1016/j.tvjl.2015.09.016

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A case of canine epitheliotropic lymphoma (mycosis fungoides)

Journal of the Hellenic Veterinary Medical Society (2018)

Manolis N. Saridomichelakis C. K. KOUTINAS A. F. KOUTINAS

The clinical picture, diagnosis and treatment of a dog with epitheliotropic lymphoma are presented. The dog (male, mongrel, 13-year old) was admitted to our Clinic with a 5-month history of non-pruritic skin lesions. At clinical examination a multifocal to diffuse exfoliative erythrodermia was the most striking finding. Diagnosis of epitheliotropic lymphoma was based on cutaneous histopathology, revealing a dense dermal and epidermal lymphocytic infiltration and Pautrie microabcess formation. Initial treatment with isotretinoin had a poor impact on skin lesions that progressed to the macular stage. On the contrary, combination chemotherapy with Lasparaginase and isotretinoin resulted in substantial improvement. The animal died, following a short period of depression and inappetance, 15 months after the first appearance of skin lesions and 10 months after diagnosis.

Histopathology

Isotretinoin

Cutaneous lymphoma

Infiltration (HVAC)

10.12681/jhvms.15459

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Detection of Tritrichomonas foetus in cats in Greece

Journal of Feline Medicine and Surgery (2010)

Panagiotis G. Xenoulis Manolis N. Saridomichelakis Sarah A. Read Jan S. Suchodolski Jörg M. Steiner

Intestinal infection of cats with Tritrichomonas foetus has been reported in the USA, Canada, several European countries, and Australia. However, T foetus has not been previously reported in cats in Greece. The aim of this study was to test fecal samples from cats living in Greece for the presence of T foetus DNA. Feces were collected from 31 cats living in Greece. DNA was extracted from the fecal samples and the presence of T foetus DNA was detected by a single-tube nested polymerase chain reaction (PCR). T foetus specific DNA was detected in the feces of 6/30 (20.0%) cats. All six cats were reported to have normal fecal quality at the time of sample collection and five of them were adults. The present study confirms for the first time the presence of T foetus in cats in Greece and suggests that T foetus infection is often asymptomatic in older cats.

Tritrichomonas foetus

10.1016/j.jfms.2010.05.010

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Prevalence, Distribution and Factors Associated with the Presence and the Potential for Malignancy of Cutaneous Neoplasms in 174 Dogs Admitted to a Clinic in Northern Greece

Journal of Veterinary Medicine Series A (2002)

H. Kaldrymidou Leonidas Leontides A. F. Koutinas Manolis N. Saridomichelakis M. Karayannopoulou

One hundred and seventy-four dogs diagnosed with cutaneous neoplasms in the Animal Medical and Surgical Clinic, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, were studied. Thirty-one types of neoplasm were diagnosed, among which mast cell tumours (13.8%), hepatoid gland adenomas (9.8%), lipomas (5.7%) and histiocytomas (5.7%) were the most common. The prevalence of epithelial, mesenchymal, lymphohistiocytic and melanocytic tumours was 47.7, 40.8, 8.6 and 2.9%, respectively. Potentially malignant neoplasms were less frequently recorded than benign neoplasms. The tumours were single (80.5%) or multiple (19.5%) and located on the head and neck (18.4%), the body trunk (49.4%), the limbs (25.9%) or at multiple sites (6.3%). The factors evaluated in multivariable logistic regression models for possible association with the odds of a tumour's potential for malignancy included the age, the sex and the breed of the dog, as well as the histological type of the neoplasm. Dogs with mesenchymal tumours had two times higher odds of potential for malignancy than those with epithelial tumours. In contrast, dogs with either lymphohistiocytic or melanocytic tumours did not have increased risk of malignancy compared with dogs with epithelial tumours. The odds of tumour malignancy linearly increased with increasing age of the dog by a factor of 1.1 per year. Finally, the effect of the sex and the breed of the dog on the risk of developing cutaneous neoplasms was investigated in an age-matched case-control sample of 348 dogs by conditional logistic regression analysis. The odds of neoplasm presence were two times higher in pure bred dogs than in mongrels but did not differ between cross-breeds and mongrels.

Neoplasm

10.1046/j.1439-0442.2002.jv408.x

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Citations (67)

A retrospective study of 61 cases of spontaneous canine epistaxis (1998 to 2001)

Journal of Small Animal Practice (2007)

Mathios E. Mylonakis Manolis N. Saridomichelakis V. Lazaridis Leonidas Leontides Polychronis Kostoulas

To determine the prevalence and identify possible clinicopathologic indicators of the diseases associated with canine epistaxis.The medical records of 61 dogs with epistaxis were reviewed.Systemic diseases, diagnosed in fifty-six dogs, included canine leishmaniasis in twenty-three dogs, canine monocytic ehrlichiosis in twenty-two, concurrent canine leishmaniasis and canine monocytic ehrlichiosis in six, rodenticide toxicity in two and primary immune-mediated thrombocytopenia, suspected oestrogen toxicity and systemic arterial hypertension in one dog each. Intranasal diseases were documented in the remaining five dogs, including transmissible venereal tumour in three dogs, and nasal adenocarcinoma and nasal aspergillosis in one dog each. Mucosal pallor and a generalised bleeding tendency were significantly more common among dogs with canine monocytic ehrlichiosis compared with those with canine leishmaniasis, whereas the opposite was true for peripheral lymphadenomegaly. Also, dogs with canine monocytic ehrlichiosis presented with pancytopenia more frequently compared with those with canine leishmaniasis; in the latter dogs, the median values of haematocrit, leucocyte and platelet counts and serum total protein concentrations were higher.Canine leishmaniasis and canine monocytic ehrlichiosis are the leading causes of canine epistaxis in Greece. Mucosal pallor, bleeding tendency and pancytopenia are more likely to be indicative of canine monocytic ehrlichiosis, as opposed to peripheral lymphadenomegaly and hyperproteinaemia in canine leishmaniasis.

Ehrlichiosis

Canine leishmaniasis

Pallor

Ehrlichia canis

10.1111/j.1748-5827.2007.00441.x

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Citations (36)