Yiu Yan Leung

University of Hong Kong

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Dion Tik Shun Li

University of Hong Kong

Andy Wai Kan Yeung

University of Hong Kong

Colman McGrath

University of Hong Kong

Kuo Feng Hung

University of Hong Kong

Natalie Sui Miu Wong

St. Michael's Hospital

Kar Yan Li

University of Hong Kong

Lim Kwong Cheung

University of Hong Kong

Michael M. Bornstein

University of Basel

Prasanna Neelakantan

University of Alberta

Yu‐Xiong Su

University of Hong Kong

Cooperative Institutions

University of Hong Kong

135

Chinese University of Hong Kong

Prince Philip Dental Hospital

Queen Mary Hospital

Prince of Wales Hospital

HKU-Pasteur Research Pole

University of Hong Kong - Shenzhen Hospital

United Christian Hospital

Chinese Academy of Medical Sciences & Peking Union Medical College

National University of Singapore

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Satisfaction with Government Recommended Pre-Procedural Mouth Rinses in the Mitigation of Covid-19 in Hong Kong SAR: A Triple Blind Randomized Controlled Clinical Trial

Journal of Dentistry (2024)

Shan Huang Yiu Yan Leung Prasanna Neelakantan Kwok Hung Chan Ka‐Yi Leung

Mouth rinse

10.1016/j.jdent.2024.105082

Cite

Citations (0)

Small molecule based anti-virulence approaches against Candida albicans infections

Critical Reviews in Microbiology (2022)

Shanthini Kalimuthu Om Alkhir Alshanta Akshaya Lakshmi Krishnamoorthy Akhila Pudipeddi Adline Princy Solomon

Fungi are considered "silent killers" due to the difficulty of, and delays in diagnosis of infections and lack of effective antifungals. This challenge is compounded by the fact that being eukaryotes, fungi share several similarities with human cellular targets, creating obstacles to drug discovery. Candida albicans, a ubiquitous microbe in the human body is well-known for its role as an opportunistic pathogen in immunosuppressed people. Significantly, C. albicans is resistant to all the three classes of antifungals that are currently clinically available. Over the past few years, a paradigm shift has been recommended in the management of C. albicans infections, wherein anti-virulence strategies are considered an alternative to the discovery of new antimycotics. Small molecules, with a molecular weight <900 Daltons, can easily permeate the cell membrane and modulate the signal transduction pathways to elicit desired virulence inhibitory actions against pathogens. This review dissects in-depth, the discoveries that have been made with small-molecule anti-virulence approaches to tackle C. albicans infections.

Fungal pathogen

Human pathogen

Opportunistic pathogen

10.1080/1040841x.2021.2025337

Cite

Citations (8)

Craniomaxillofacial Trauma and Reconstruction: A New Era in Open Access Publishing

Craniomaxillofacial Trauma & Reconstruction (2025)

Yiu Yan Leung Kathleen Fan Florian M. Thieringer

Craniomaxillofacial Trauma and Reconstruction (CMTR) [...]

10.3390/cmtr18010001

Cite

Citations (0)

The Impact of Coronavirus Disease 2019 on the Disease Pattern of Oral and Maxillofacial Surgery Inpatients: A Comparative Study

Frontiers in Medicine (2021)

Jingya Jane Pu Colman McGrath Yiu Yan Leung Wing Shan Choi Wei‐fa Yang

Objective: Oral and maxillofacial surgery (OMFS) is a high-risk specialty involving airway and aerosol-generating procedures, which is potentially of more risk in the era of coronavirus disease 2019 (COVID-19). We aimed to identify the impact of COVID-19 on the disease pattern of OMFS inpatients and surgeries under general anesthesia in a comparative study. Materials and Methods: We reviewed the admission and operating theater records of OMFS patients from Jan 1 to Aug 31 in 2020 and 2019. The total number of cases, presenting disease patterns, and proportion of essential and non-essential medical services were compared between 2020 and 2019. Results: There were 664 admissions and 356 general anesthesia surgical procedures included in this study. Both admission and surgery numbers were significantly reduced in 2020, compared with 2019 ( p = 0.012 and 0.007, respectively). The proportion of malignancy cases increased significantly, whereas that of cleft lip and palate and temporomandibular disorder (TMD) decreased. There was a significant increase in the proportion of essential services compared with non-essential services in 2020 compared with 2019. Conclusion: Our results first reported the epidemiological data of the impact of COVID-19 on OMFS disease pattern in a comparative study. The change of disease pattern and caseload will have a long-term impact on OMFS patient care, education, and training during the pandemic. Our paper provides evidence for health policy makers to consider the relocation of medical resources and optimization of medical education and services.

Pandemic

10.3389/fmed.2021.613663

Cite

Citations (6)

Linear and angular measurement using cone-beam computed tomography to enhance safety in Le Fort I osteotomy with tuberosity cut

Clinical Oral Investigations (2022)

Liuling Hui Kuo Feng Hung Michael Marc Bornstein Yiu Yan Leung

10.1007/s00784-022-04669-6

Cite

Citations (3)

Bone regeneration at the distal aspect of the adjacent second molar after lower third molar coronectomy: a long-term analysis

International Journal of Oral and Maxillofacial Surgery (2020)

Yiu Yan Leung Andy Wai Kan Yeung Izzati Nabilah Ismail Natalie Sui Miu Wong

Impaction

10.1016/j.ijom.2020.03.016

Cite

Citations (12)

Lavage Volume of Arthrocentesis in the Management of Temporomandibular Disorders: A Systematic Review and Meta-Analysis

Diagnostics (2022)

Hei Christopher Tsui Chun Mo Lam Yiu Yan Leung Kar Yan Li Natalie Sui Miu Wong

The aim of this study was to investigate the most effective lavage volume of arthrocentesis in the management of temporomandibular disorders. A comprehensive electronic search, based on the PRISMA guidelines, was performed, which included a computer search with specific keywords, a reference list search and a manual search. The inclusion criteria were the following: a randomized controlled trial, at least 20 subjects who underwent arthrocentesis, mention of the irrigation materials used for the arthrocentesis, mention of the irrigation volumes used for the arthrocentesis, MMO and pain measured as VAS or NRS, were reported as outcome figures, mention of a specific diagnosis or signs and symptoms, and inclusion of the data on the MMO or VAS/NRS at 6-month follow-up. Sixteen publications were enrolled in the meta-analysis, comparing arthrocentesis with a lavage volume <150 mL and arthrocentesis with a lavage volume ≥150 mL, in the efficacy of the improvement in the mouth opening and pain reduction. The results revealed the group with a lavage volume <150 mL had a greater improvement in the mouth opening and pain reduction. However, results are to be interpreted with caution, due to the paucity of the randomized controlled literature and other confounding factors. Further high-quality studies are required to provide a better conclusion to the treatment outcomes of the different lavage volumes.

Arthrocentesis

Therapeutic irrigation

10.3390/diagnostics12112622

Cite

Citations (6)

Safety of coronectomy versus excision of wisdom teeth: A randomized controlled trial

Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology (2009)

Yiu Yan Leung Lim Kwong Cheung

Dry socket

10.1016/j.tripleo.2009.07.004

Cite

Citations (169)

Stability of intraoral vertical ramus osteotomies for mandibular setback

International Journal of Oral and Maxillofacial Surgery (2017)

Y.H. Kung Yiu Yan Leung

Mandibular prognathism

Prognathism

Setback

Mandible (arthropod mouthpart)

10.1016/j.ijom.2017.02.550

Cite

Citations (0)

Early Arthrocentesis for Temporomandibular Joint Arthralgia: A Superiority Trial

International Dental Journal (2024)

Dion Tik Shun Li Lai Ying Luo Kar Yan Li Yu‐Xiong Su Justin Durham

The aim of this superiority trial was to investigate the clinical outcomes of arthrocentesis as an early treatment supported by use of an occlusal splint vs use of an occlusal splint only in the management of temporomandibular joint (TMJ) arthralgia. Ninety-five adults presenting with TMJ arthralgia were recruited into the study and randomised into 2 groups: Group 1 received arthrocentesis as an early treatment supported by use of an occlusal splint, whereas group 2 received treatment with an occlusal splint only. Seventy-four patients (group 1: n = 37; group 2: n = 37) completed the 1-year follow-up schedule and were included in the final analysis. Reduction of pain intensity measured by a numeric rating scale and increase in mouth opening distance (unassisted maximal, assisted maximal, and pain-free) was seen in both treatment groups. In group 1, pain intensity significantly decreased at 6 weeks and all subsequent time points compared with group 2. In terms of mouth opening distance, a significant improvement was observed in both groups during the course of treatment, but statistical significance was not seen between the 2 treatment groups. Early arthrocentesis supported by use of an occlusal splint is superior to use of an occlusal splint alone in the treatment of TMJ arthralgia. Arthrocentesis with occlusal splint support could be discussed as first-line treatment for arthralgia of the TMJ, which may co-occur with various painful and nonpainful conditions of TMJ disorders.

Arthrocentesis

10.1016/j.identj.2024.04.015

Cite

Citations (1)