Amirhossein Poopak

Tehran University of Medical Sciences

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Fatemeh Dehghani Firouzabadi

Iran University of Medical Sciences

Fatemeh Moosaie

Tehran University of Medical Sciences

Alireza Esteghamati

Tehran University of Medical Sciences

Manouchehr Nakhjavani

Tehran University of Medical Sciences

Ali Sheikhy

Tehran University of Medical Sciences

Amirsina Sharifi

Tehran University of Medical Sciences

Soghra Rabizadeh

Imam Khomeini Hospital

Niloofar Deravi

Tehran University of Medical Sciences

Mohammad Dehghani Firouzabadi

Tehran University of Medical Sciences

Jeffrey I. Mechanick

Icahn School of Medicine at Mount Sinai

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Tehran University of Medical Sciences

113

Imam Khomeini Hospital

University of Tehran

Iran University of Medical Sciences

Shahid Beheshti University of Medical Sciences

Universal Scientific Education and Research Network

Institute for Health Metrics and Evaluation

University of Washington

Shariati Hospital

Isfahan University of Medical Sciences

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Compression stockings for treating vasovagal syncope (COMFORTS-II) trial: Rationale and design of a triple-blind, multi-center, randomized controlled trial

American Heart Journal (2022)

Hamed Tavolinejad Amirhossein Poopak Saeed Sadeghian Ali Bozorgi Alireza Oraii

Vasovagal Syncope

Compression stockings

Tilt table test

10.1016/j.ahj.2022.04.002

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Citations (3)

National and subnational burden of leukemia and its risk factors, 1990–2019: Results from the Global Burden of Disease study 2019

PLoS ONE (2023)

Amirhossein Poopak Sahar Saeedi Moghaddam Zahra Esfahani Mohammad Keykhaei Negar Rezaei

Hematologic malignancies have a great essential role in cancer global burden. Leukemia which two major subtypes based on the onset, is one of the common subtypes of this malignancy.For the GBD 2019 study, cancer registry data and vital registration system were used to estimate leukemia mortality. The Meta-Regression-Bayesian Regularized Trimmed (MR-BRT), Cause of Death Ensemble model (CODEm) and Spatiotemporal Gaussian Process Regression (ST-GPR) were used to model our data and estimate each quantity of interest. Mortality to incidence ratios (MIR) were used to generate incidence and survival from mortality rate. Prevalence and survival were used to generate years lived with disability (YLDs). Age-specific mortality and life expectancy at the same age were used to estimate years of life lost (YLLs). The sum of YLLs and YLDs generates DALYs.The total national incidence of leukemia increased from 6092 (UI 95%: 3803-8507) in 1990 to 6767 (4646-7890) new cases in 2019. However, leukemia age-standardized incidence ratio(ASIR) decreased from 11.6 (8-14.8) to 8.9 (6.2-10.3) new cases per 100,000 in this exact period. At the national level, deaths from leukemia increased 1.5-fold between 1990 and 2019, from 3287 (2284-4201) to 4424 (3137-5030), whereas the age-standardized death rate(ASDR) decreased from 8.3 (6.1-9.8) in 1990 to 6 (4.3-6.8) per 100,000 in 2019. In the study period, total leukemia DALYs decreased 12.2% and reached 162850 (110681-188806), in 2019. The age-standardized DALYs decreased 36.7% from 324.3 (224.8-413.4) in 1990 to 205.3 (140.3-237.8) in 2019. ASDR, DALYs, YLLs, and YLDs rate to high BMI was increasing while smoking and occupational exposure to benzene and formaldehyde were decreasing in the study period.This study provided a better understanding of leukemia burden and to reduce controversies of leukemia across Iran. The leukemia status alteration of the country, is trackable.

10.1371/journal.pone.0287917

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Citations (4)

Challenges to Lifestyle Medicine for Type 2 Diabetes in Iran: A Synoptic Review

American Journal of Lifestyle Medicine (2023)

Mohammad Dehghani Firouzabadi Ali Sheikhy Amirhossein Poopak Alireza Esteghamati Jeffrey I. Mechanick

Type 2 diabetes (T2D) is a major public health issue in Iran. The principal context for T2D management is the prevention of cardiovascular disease development and progression. These preventive strategies can be enhanced with routine implementation of comprehensive lifestyle modification, guideline-directed medical therapies, and creation of infrastructure that considers social determinants of health, ethnocultural variables, and financial challenges. In this synoptic review, scientific evidence sourced from Iran is analyzed to identify tactics to optimize the lifestyle medicine component of T2D care in Iran. Important evidence-based factors gleaned from the literature were curated into 9 categories: self-care, dietary adherence, mental health, self-comparison, transcultural adaptation, family support and community engagement, physical activity, the global pandemic, and service delivery. These categories were then assigned to 1 of 4 a priori aspects challenging diabetes care in Iran: behavioral factors, belief system, drivers, and implementation. By codifying discussion points and individual tactics, the improvement and optimization of T2D care in Iran can be facilitated. This reductionist model of approaching lifestyle medicine and complex chronic disease such as T2D can be applied to other ethnocultural populations.

Lifestyle medicine

Guideline

Pandemic

10.1177/15598276231167787

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Citations (1)

Severe liver steatosis as potential risk factor of cardiovascular disease in patients with type 2 diabetes: a prospective cohort study

Research Square (Research Square) (2023)

Mohammad Dehghani Firouzabadi Amirhossein Poopak Ali Sheikhy Fatemeh Dehghani Firouzabadi Fatemeh Moosaie

Abstract Background and Aims: Non-alcoholic fatty liver disease (NAFLD), accelerates the progression of atherosclerosis and development of cardiovascular diseases (CVD) which is the most common cause of mortality in NAFLD patients. Methods and results In this prospective cohort study, 1197 patients with type 2 diabetes (T2D) were divided in to two groups (360 patients with NAFLD and 847 without) and were followed for median of 5 years for incidence of CVD. Cox regression analysis was used to assess the association between NAFLD, level of liver enzymes, and aspartate aminotransferase to platelet ratio index (APRI), and incidence risk of CVD and its subgroups (i.e., Myocardial Infarction, chronic heart disease, coronary artery bypass grafting, and percutaneous coronary intervention. There was a significant positive association between CVD incidence and NAFLD (HR = 1.487, 95% CI = 1.041–2.124, p-value = 0.029). Although patients with NAFLD had higher ALT and AST levels (p-value = < 0.001), there was no significant association between liver enzymes and the incidence risk of CVD when adjusting for different variables. Furthermore, NAFLD was linked to APRI Q (2), APRI Q(3), and APRIQ(4) NAFLD (1.365 (1.046–1.781), 1.623 (1.234–2.135), and 3.373 (2.509–4.536), respectively. Conclusion NAFLD increased the incidence risk of CVD in T2D. However, there was no association between liver enzymes (ALT, AST, ALK-P, and GGT) and a higher incidence risk of CVD in T2D when adjusted for confounding variables.

Steatosis

10.21203/rs.3.rs-3131077/v1

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Citations (2)

Effects of a Mediterranean diet on the development of diabetic complications: A longitudinal study from the nationwide diabetes report of the National Program for Prevention and Control of Diabetes (NPPCD 2016-2020)

Maturitas (2021)

Fatemeh Ghaemi Fatemeh Dehghani Firouzabadi Fatemeh Moosaie Mahdi Shadnoush Amirhossein Poopak

10.1016/j.maturitas.2021.08.003

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Citations (37)

Efficacy and safety of tipepidine as adjunctive therapy in major depressive disorder: A randomized, double‐blind, placebo‐controlled clinical trial

Psychiatry and Clinical Neurosciences (2020)

Saba Hoobehfekr Hossein Sanjari Moghaddam Mohammadreza Shalbafan Maryam Ghazizadeh Hashemi Mohammad Mehdi Pirmoradi

Tipepidine, a synthetic, non-opioid expectorant, has been shown to improve depressive-like behavior in animal models of depression. In this study, we assessed the efficacy and tolerability of tipepidine combination therapy with citalopram in treatment of major depressive disorder (MDD).In a randomized, double-blinded, placebo-controlled clinical trial, 62 patients with MDD were assigned into two parallel groups to receive citalopram (up to 40 mg/day) plus placebo or citalopram plus tipepidine (30 mg twice daily) for 6 weeks. Participants were assessed with the Hamilton Rating Scale for Depression (HAM-D) at baseline and Weeks 2, 4, and 6.Fifty-six patients completed the trial. The tipepidine group showed greater improvement in HAM-D scores from baseline to all three study time points (P = 0.048 for all). The remission and response-to-treatment rates were significantly higher in the tipepidine group (53.6% and 100%) compared to the placebo group (25.0% and 75%) at the study end-point (P = 0.029 and 0.005, respectively). The remission and response times in patients in the tipepidine group were also shorter compared with the placebo group (log-rank P = 0.020 and 0.004). There was no significant difference between the two groups in baseline parameters or frequency of side-effects.Tipepidine combination therapy with citalopram can effectively improve symptoms of patients with MDD in a shorter period of treatment. However, further studies with larger sample sizes and longer follow-up treatment are needed to confirm our findings.

Citalopram

Tolerability

Depression

10.1111/pcn.13180

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Citations (6)

What are the determinants of parametrial invasion in patients with early stage cervical cancer: A cross sectional study

Annals of Medicine and Surgery (2022)

Niloufar Hoorshad Narges Zamani Shahrzad Sheikh Hasani Amirhossein Poopak Amirsina Sharifi

There was an increase in number of patients presented with early-stage cervical cancer (CC). Tumors with favorable pathological features might be candidates for less radical surgery.We retrospectively reviewed 700 patients with histologically confirmed CC between January 2011 and March 2020. Chi-square, Fisher's exact tests and multivariate logistic regression analysis were used to assess relations between parametrial involvement (PI) and clinic-pathological variables.Total number of 132 patients with stage IA to IIA were eligible to participate. Squamous cell carcinoma was reported in 100 (75.8%) patients, adenocarcinoma and other tumor pathologies were found in 24(18.2%) and 8(6.1%), respectively. Considering the 2018 FIGO stage, 11 (8.4%) patients had IA, 111 (83%%) IB and 10 (7.6%) IIA. Nine patients (6.8%) had PI on permanent pathologic report. Univariate analysis demonstrated that following variables were statistically different between patients with and without PI: age ≥50, tumor size ≥ 3 cm, lower segment involvement, poorly differentiated pathology, deep stromal invasion, pelvic lymph node, lympho-vascular involvement and positive surgical margin (all p values < 0.05). Among these variables only tumor size ≥3 cm (OR: 2.1, 95% CI: 1.11-4.16, p value: 0.02), deep stromal invasion (OR: 2.2, 95% CI: 1.9-7.43, p value: 0.02) and positive surgical margin (OR: 5.1, 95% CI: 3.97-11.15, p value: 0.008) were independent risk factor of PI in multivariate analysis.Early stage CC might be surgically approached in a more conservative manner if patients have tumor size <3 cm and do not have deep stromal invasion in conization.

Parametrial

Univariate analysis

Parametrium

Cross-sectional study

10.1016/j.amsu.2022.104020

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Incidence of Symptomatic COVID-19 in Close Contacts of Patients After Discharge From Hospital

Research Square (Research Square) (2021)

Ayat Ahmadi Amirhossein Poopak Sina Nazemi Negin Mohammadi Bita Eslami

Abstract Background: There is a little evidence about the infectiousness of recovered COVID-19 patients. Considering that the circumstance of the isolation of the COVID-19 patients after-discharge is not always optimal, it is not very unlikely that viral transmission still occurs after hospital discharge. This study aims to investigate incidence of symptomatic COVID-19 in close contacts of recovered patients after discharge from hospital Methods: Four hundred fifty discharged COVID-19 patients discharged from the largest public treatment center in Tehran, capital city of Iran were followed up. Demographic and clinical data of participants were collected from medical records. Follow-up data were acquired via telephone call interviews with patients or their main caregivers at home. Results : The study's response rate was 93.77%(422 participated in the study). 257 patients were male (60.90%) and 165(39.10%) were female (sex ratio =1.55 male). The most prevalent comorbidities in these patients were hypertension (n=111, 29.68%) and diabetes (n=93, 24.80%). The mean±sd of home isolation after discharge was 25.85±23.78. Forty-one (9.71%) patients had at least one new case in their close contacts up to three weeks since they discharged. There was a significant association between having at least a comorbidity with the odds of getting infected in close contacts [OR(CI): 2.45 (1.05 – 4.72); P: .03]. Density of inhabitant per houses rooms and the quality of isolation had significant associations with observing new cases in the patients' close contacts [high to moderate; OR(CI): 2.44 (1.06 – 5.61); P: .03], [ bad to good; OR(CI): 2.31 (1.17 – 4.59); P: .01], respectively. Conclusion : After hospital discharge, COVID-19 transmission can still occur, when number of people lives together in a single house. An explanation can be that the less precaution measures are taken by recovered patients’ cohabitants. Such condition is more likely to happen when the recovered patient has other chronic diseases.

Hospital discharge

Medical record

Isolation

Odds

10.21203/rs.3.rs-727168/v1

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Effect of joint immobilization using extension splint immediately after total knee arthroplasty on post-operative knee function and pain: a randomized clinical trial

International Orthopaedics (2022)

Mohammad Hasan Kaseb Alireza Moharrami Peyman Mirghaderi Ehsan Fallah Mohammadreza Razzaghof

10.1007/s00264-022-05428-8

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Citations (7)

Prevalence of metabolic dysfunction–associated fatty liver disease among patients with diabetic kidney disease: a systematic review and meta-analysis

Egyptian Liver Journal (2024)

Mohammad Rahmanian Niloofar Deravi Mohadeseh Poudineh Amirhossein Poopak Seyed Nooshan Mirmohammadali

Abstract Background Mechanistic relationships between metabolic dysfunction–associated fatty liver disease (MAFLD) and chronic kidney disease are well characterized. Specifically, in type 2 diabetes (T2D), insulin resistance leads to MAFLD, and hyperglycemia leads to microvascular complications such as diabetic kidney disease (DKD). This systematic review and meta-analysis aims to describe the specific association between MAFLD and DKD for the first time. Methods PubMed, Web of Science, Google Scholar, and Scopus databases were searched up to February 2023 to identify relevant published articles. After screening the titles, abstracts, and full texts of the retrieved articles, cross-sectional studies and cohorts reporting on MAFLD in patients with DKD were identified and then analyzed. Results A total of 2615 articles were identified, of which 5 had sufficient data and fulfilled the eligibility criteria for meta-analysis. A total of 2345 patients with DKD were in the included studies. The prevalence rates of radiologically diagnosed MAFLD among patients with DKD ranged from 25 to 96%. The pooled prevalence rate of radiologically diagnosed MAFLD among patients with DKD was 0.55 (95% CI = 0.21–0.89, I 2 = 99.79%, P -value < 0.01). Conclusion MAFLD is prevalent in patients with DKD. This finding emphasizes the need for aggressive case finding and then guideline-directed medical therapy of MAFLD, especially in patients with T2D and DKD to prevent further complications. Future studies should investigate mechanisms underpinning MAFLD and DKD in patients with T2D, especially in the context of cardiometabolic risk.

Metabolic disease

10.1186/s43066-024-00393-w

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