Mary Ann Bellinger

New York State Department of Health

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Hassan A. Gaafar

Animal Health Research Institute

William D. Lawton

New York State Department of Health

Marion Schling

New York State Department of Health

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New York State Department of Health

Animal Health Research Institute

The Ohio State University

University of Illinois Urbana-Champaign

Merck Institute for Science Education

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Purdue University West Lafayette

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Bacteriocin Production by Neisseria gonorrhoeae

Antimicrobial Agents and Chemotherapy (1976)

William D. Lawton Mary Ann Bellinger Marion Schling Hassan A. Gaafar

Seventeen apparently unrelated isolates of Neisseria gonorrhoeae out of 2,123 tested produced a diffusible growth-inhibitory substance against other gonococci. The inhibitor was destroyed by trypsin, not blocked by bovine serum albumin, and not soluble in chloroform-methanol; each isolate was resistant to the inhibitor it produced. Thus, the substance differs from previously described gonococcal inhibitors, and since it fits the description of a bacteriocin we designated it gonocin. The use of gonocin for typing was complicated by the observation that susceptibility to gonocin appears to depend on the gonococcal colony type.

Neisseria gonorrhoeae

Neisseriaceae

Bovine serum albumin

10.1128/aac.10.3.417

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Bacteriocin Production byNeisseria gonorrhoeae

Mary Ann Bellinger

eachisolate wasresistant to theinhibitor itproduced. Thus, thesubstance differs frompreviously described gonococcal inhibitors, andsince itfits thedescription ofabacteriocin wedesignated itgonocin. Theuseofgonocin fortyping wascomplicated bytheobservationthatsusceptibility togonocin appears todepend onthegonococcal colony type. Bacteriocins areantibacterial proteins that areproduced bybacteria andactagainst others ofthesameorrelated species (8). Since typing schemes arelimited forNeisseria gonorrhoeae andsince bacteriocin typing hasbeenusedto classify various microorganisms (2,8),weand others haveinvestigated thepossibility ofbacteriocin production byN.gonorrhoeae. Flynn andMcEntegart (3) reported that75of100gonococcal isolates tested produced bacteriocins, butWalstad etal.(9)wereunable toconfirm their observation. Thelatter authors found that N.gonorrhoeae produce inhibitory fatty acids andlysophosphatidylethanolamine butnottrue bacteriocins. Knappetal.(7)also found anonspecific inhibitor butnobacteriocins produced byN.gonorrhoeae. Kingsbury (6)reported on bacteriocin production intheclosely related Neisseria meningitidis. Thisreport details our observations ongonococcal bacteriocin production.

Neisseria gonorrhoeae

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