Ai‐Hong Yang

Tianjin University of Traditional Chinese Medicine

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Jian‐Zhong Cui

Tianjin University

Hong‐Ling Gao

Tianjin University

Hong-Ling Gao

Li-Hua Zhao

Tianjin Children's Hospital

Ying-Ping Quan

Tianjin University

Rui Shen

Tianjin University of Traditional Chinese Medicine

Peng Cheng

Nankai University

Xiaodi Kou

Tianjin University of Traditional Chinese Medicine

Su-Rong Fang

Tianjin University

Wei Shi

Nankai University

Cooperative Institutions

Tianjin University of Traditional Chinese Medicine

Chinese Academy of Sciences

Tianjin University

Nankai University

University of Chinese Academy of Sciences

Chinese Academy of Medical Sciences & Peking Union Medical College

Peking University

Lanzhou University

Nanjing Medical University

Collaborative Innovation Center of Chemical Science and Engineering Tianjin

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Formation of the Water Layer in Lanthanide Coordination Polymers with 6-Methyl-2,3,5-Pyridinetricarboxylate as a Novel Bridging Ligand

Crystal Growth & Design (2009)

Ai‐Hong Yang Lihua Zhao Ying-Ping Quan Hong‐Ling Gao Jian‐Zhong Cui

Four coordination polymers with lanthanide ions and the novel ligand 6-methyl-2,3,5-pyridinetricarboxylic acid (H3mptc), {[Ln(mptc)(H2O)4]·3H2O}n, [Ln = Pr (1), Nd (2), Sm (3), Tb (4)], have been synthesized by the self-assembly reaction of potassium 6-methyl-2,3,5-pyridinetricarboxylate (K3mptc) and rare earth salts in aqueous solution. The complexes were characterized by X-ray diffraction single crystal structure analysis, elemental analysis, IR, fluorescence and thermal analysis. The four coordination polymers are isotypics and crystallize in the monoclinic system with the P21/n space group. The Ln(III) ions are coordinated by three carboxylate groups with different coordination modes and link to form an infinite two-dimensional (2D) polymer. Infinite T6(2) water tapes containing puckered-boat hexameric water rings exist in the space between the metal crystal building layers. The T6(2) water tapes self-assemble into novel 2D L6(5)14(8) water layers through (H2O)2 dimers between adjacent water tapes.

Monoclinic crystal system

Coordination polymer

Carboxylate

Bridging ligand

10.1021/cg9008575

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Citations (17)

ds-Block metal ions catalyzed decarboxylation of pyrazine-2,3,5,6-tetracarboxylic acid and the complexes obtained from hydrothermal reactions and novel water clusters

CrystEngComm (2009)

Ai‐Hong Yang Ying-Ping Quan Hong‐Ling Gao Su-Rong Fang Yan-Ping Zhang

The factors that influence the decarboxylation of pyrazine-2,3,5,6-tetracarboxylic acid (H4pztc) under hydrothermal conditions were investigated. Higher temperature and lower pH are very effective promoters for the decarboxylation of H4pztc in the presence of ds-block metal ions. Four novel complexes of H4pztc and four complexes from the decarboxylation of H4pztc, [Zn2(pz25dc)(phen)4](NO3)2·10H2O (1), [Zn2(pztc)(phen)4]·12H2O (2), {[Zn2(pztc)(bpy)2(H2O)2]·2H2O}n (3), [Cu2(pz25dc)(phen)4](NO3)2·10H2O (4), {[Cu2(pztc)(bpy)2 H2O]·4H2O}n (5), [Cu2(H2pztc)(bpy)2(H2O)2](NO3)2·2H2O (6), [Cd(pz26dc)(phen)(H2O)2] (7) and [Cd(pz26dc)(bpy)(H2O)2] (8) (pz25dc = pyrazine-2,5-dicarboxylate, pz26dc = pyrazine-2,6-dicarboxylate, phen = 1,10-phenanthroline, bpy = 2,2′-bipyridyl) have been synthesized and characterized by X-ray single crystal diffraction, elemental analysis, IR, thermal gravimetric analysis (TGA) and fluorescence measurement. 1, 2, 4 and 6 are dinuclear complexes bridged by pztc or pz25dc, 3 and 5 are 1D coordination polymers. In 6, the Cu(II) ions are bridged by bis-tridentate H2pztc2−. 7 and 8 are mononuclear Cd(II) complexes. The 2D or 3D supramolecular structures of 1–8 were built up by hydrogen bonds and π⋯π interactions. Notably, a novel T5(0)A0 water tape and a S-shaped (H2O)10cluster are observed in 2 and 5, respectively.

Decarboxylation

Pyrazine

Thermogravimetric analysis

10.1039/b911939f

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Citations (26)

CCDC 774610: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Ai‐Hong Yang Li-Hua Zhao Xue‐Jie Qi Yiwei Lu

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccv01f9

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A coumarin-based multifunctional chemosensor for Cu2+/Al3+ as an AD theranostic agent: Synthesis, X-ray single crystal analysis and activity study

Analytica Chimica Acta (2023)

Xiaodi Kou Chengting Hu Zi Pang Xinyu Zhang Huiyan Wang

10.1016/j.aca.2023.341818

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Citations (6)

Design, synthesis, and biological evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as novel acetylcholinesterase inhibitors

ARKIVOC (2009)

Sijie Liu Ai‐Hong Yang Zhe Jin Er-Fang Huang David Chi Cheong Wan

The docking study on a novel series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives with acetylcholinesterase from Torpedo californica has demonstrated that the ligands bind to the dualsite of the enzyme.The synthesis and characterization of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives was described.The crystal structure of 6-benzyl-3-{4-[2-(1-piperidinyl)-2oxoethoxy]phenyl}thiazolo[3,2-b]-1,2,4-triazin-7-one has been characterized by X-ray diffraction.All target compounds have been screened for their efficacy as acetylcholinesterase inhibitor.The study of AChE inhibitory activity was carried out using the Ellman colorimetric assay with huperzine-A as a reference against targets.Most of the target compounds exhibit more than 50% inhibition at 10 µM.Some derivatives showed good inhibition against AChE.The preliminary structure-activity relationships were discussed.

10.3998/ark.5550190.0010.a30

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Citations (20)

Anticancer effect of a combination of cisplatin and matrine on cervical cancer U14 cells and U14 tumor-bearing mice, and possible mechanism of action involved

Tropical Journal of Pharmaceutical Research (2022)

Ai‐Hong Yang Jun Zhu Feixue Xu Yang Jiao Ying Wang

Purpose: To investigate the anticancer effects of cisplatin (DDP) in combination with matrine on cervical cancer U14 cell tumor-bearing mice. Methods: The cell proliferation of cervical cancer U14 cells treated with DDP (25, 20, 15, 10 and 5 μg/mL); matrine (2.5, 2.0, 1.5, 1.0 and 0.5 mg/mL); or DDP (15 μg/mL) + matrine (2.5, 2.0, 1.5, 1.0 and 0.5 mg/mL) was determined with MTT assay. The anticancer effect of DDP + matrine in U14 tumor-bearing mice was also investigated, based on expression of tumor suppressor lung cancer 1 (TSLC1) using quantitative real time-polymerase chain reaction (qRT-PCR) and immunohistochemistry. Results: The inhibition of proliferation of U14 cells ranged from 26.68–70.25, 10.20–61.73, and 51.89–89.75 % for DDP, matrine and DDP + matrine, respectively. In mice with U14 solid tumors, the DDP group had 12.3 % weight loss (p < 0.05). Treatment with DDP, matrine, and DDP + matrine reduced tumor growth by 64.56, 42.22–56.67, and 67.78–81.11 %, respectively (p < 0.01). Results from RT-qPCR and immunohistochemistry showed corresponding increases in expression levels of TSLC1. Conclusion: These results indicate that the anticancer activity of DDP + matrine is higher than that of a single treatment with either DPP or matrine. The likely mechanism of action might be related to promotion of TSLC1 expression. This finding provides a potential strategy for the management of cervical cancer.

10.4314/tjpr.v20i8.12

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Citations (2)

CCDC 705656: Experimental Crystal Structure Determination

The Cambridge Structural Database (2010)

Ying-Ping Quan Li-Hua Zhao Ai‐Hong Yang Jian-Zhong Cui Hong-Ling Gao

10.5517/ccrp93t

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Citations (0)

CCDC 682362: Experimental Crystal Structure Determination

The Cambridge Structural Database (2010)

Ai‐Hong Yang Ying-Ping Quan Hong-Ling Gao Su-Rong Fang Yan-Ping Zhang