Walter Jaeger

University of Vienna

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Co-Authors

Thomas Szekeres

Medical University of Vienna

Philipp Saiko

Medical University of Vienna

Monika Fritzer‐Szekeres

Medical University of Vienna

Michael Grusch

Medical University of Vienna

Zsuzsanna Bagó-Horváth

Medical University of Vienna

Thomas Erker

University of Vienna

Georg Krupitza

Medical University of Vienna

Theresia Thalhammer

Medical University of Vienna

Norbert Handler

Vienna Consulting Engineers (Austria)

Sibylle Madlener

Comprehensive Cancer Center Vienna

Cooperative Institutions

University of Vienna

121

Medical University of Vienna

115

Vienna General Hospital

Comprehensive Cancer Center Vienna

Centro de Investigación Biomédica en Red

Instituto de Salud Carlos III

University of Alberta

Universitat de Barcelona

Universitätszahnklinik Wien

Universität Innsbruck

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A novel N-hydroxy-N′-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C)

Biochemical Pharmacology (2010)

Philipp Saiko Geraldine Graser Benedikt Giessrigl Andreas Lackner Michael Grusch

Ribonucleotide reductase

CDC25A

Aphidicolin

Deoxyribonucleosides

Ribonucleotide

10.1016/j.bcp.2010.09.006

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Citations (11)

Combination Effects of Digalloylresveratrol With Arabinofuranosylcytosine and Difluorodeoxycytidine in Human Leukemia and Pancreatic Cancer Cells

Nucleosides Nucleotides & Nucleic Acids (2011)

Philipp Saiko Geraldine Graser Sibylle Madlener Simone Schwarz Georg Krupitza

Digalloylresveratrol (DIG) is a newly synthesized agent aimed to combine the biological effects of the natural compounds, gallic acid and resveratrol, which both are free radical scavengers exhibiting anticancer activity. In this study, we investigated the effects of DIG on the growth of human HL-60 leukemia cells and on the colony formation of human BxPC-3 and PANC-1 pancreatic cancer cells. DIG was applied alone and in combination with arabinofuranosylcytosine (Ara-C) or difluorodeoxycytidine (dFdC), depending on the cell line employed. All IC50 values observed were in the low micromolar range rendering DIG a promising antitumor compound in vitro. Considering the combination experiments, DIG yielded additive effects with Ara-C in HL-60 cells and—to a lesser extent—with dFdC in BxPC-3 and PANC-1 cells. Owing to our results, DIG may be further investigated in vitro and in animals.

Dig

10.1080/15257770.2011.596497

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Citations (2)

In vitro and in vivo antitumor activity of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine

International Journal of Oncology (2004)

Philipp Saiko Zsuzsanna Bagó-Horváth Wolfgang Bauer Thomas Hoechtl Michael Grusch

Various heterodinucleoside phosphates of 5-fluorodeoxyuridine (5-FdUrd) and arabinofuranosylcytosine (Ara-C) have recently been synthesized as potent chemotherapeutic agents. 5-Fluorodeoxyuridine is being used in patients with colorectal carcinoma, whereas Ara-C is one of the most effective agents in the treatment of hematological malignancies. We now investigated the action of three novel amphiphilic dimers with different structures in various 5-fluorouracil (5-FU) sensitive and resistant human colon tumor cell lines (CCL228, CCL227, 5-FU resistant CCL227 and HT-29) as well as in L1210 murine leukemia cells. Activity of the heterodimers was determined by clonogenic and growth inhibition assays including the induction of programmed cell death. In addition, the in vivo effects were tested in L1210 leukemia bearing mice. We show that these compounds inhibited the number of colonies of 5-FU sensitive and resistant human colon tumor cell lines with IC50 values ranging from 0.65 to 1 nM. The investigated dimers induced dose-dependent apoptosis in HT-29 colon tumor cells as well as in L1210 leukemia cells. No significant difference in the cytotoxicity of these agents could be observed between 5-FU sensitive and resistant cells, indicating that these compounds might be used in the treatment of 5-FU resistant tumors. In L1210 leukemia bearing mice the survival of tumor-bearing animals was significantly increased in comparison with untreated control animals. We therefore conclude that these new heterodinucleoside phosphates of 5-FdUrd and Ara-C might be an additional option for the treatment of sensitive and 5-FU resistant colon cancer and hematological malignancies.

Clonogenic assay

L1210 cells

10.3892/ijo.25.2.357

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Citations (10)

Genotoxic activities of wastewater after ozonation and activated carbon filtration: Different effects in liver-derived cells and bacterial indicators

Water Research (2020)

Miroslav Mišík Franziska Ferk Heidemarie Schaar Masami Yamada Walter Jaeger

Filtration (mathematics)

10.1016/j.watres.2020.116328

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Citations (11)

Early Antibiotic Prophylaxis Prior to Bypass Surgery Improves Tissue Penetration

The Thoracic and Cardiovascular Surgeon (2019)

Martin Andreas Markus Zeitlinger Shiva Shabanian Wilfried Wisser Rainer Thell

Abstract Background We previously identified preparation of the internal mammary artery as a risk factor significantly impairing antibiotic tissue penetration into the presternal subcutaneous tissue. We, therefore, adapted our dosing schema regarding preoperative timing to overcome this risk factor. Methods Eight patients who underwent coronary artery bypass grafting with a left internal mammary artery and vein grafts were included in this clinical trial. Cefazolin (4 g) was administered twice (3 hours and 1 hour) prior to skin incision and once during skin closure (2 g). Antibiotic concentrations were measured with subcutaneous microdialysis probes on both sternal sides. Results were directly compared with the previously published patient cohort receiving the standard schema (4 g cefazolin prior to skin incision and 2 g during closure). Results All patients (7 male, 1 female, 69 ± 7 years, 26.3 ± 3.9 kg/m2) survived the perioperative period. Mean area under the curve on the right and left sternal side was 117.0 ± 92.5 μg/mL and 114.5 ± 83.2 μg/mL, respectively (p = 0.95). This was well above the previously measured mean peak tissue concentrations without early preoperative antibiotic administration on the side of mammary artery harvesting (52.4 ± 48.5 μg/mL vs. 13.1 ± 5.8 μg/mL; p = 0.039). The %fT > minimal inhibitory concentration (MIC) for Staphylococcus epidermidis and Staphylococcus aureus during the first 10 hours in presternal tissue was ≥ 70% but did not differ compared with standard schema. Conclusions Early, additional preoperative administration of cefazolin was able to significantly increase peak tissue concentrations during surgery compared with the standard protocol. No difference, however, could be achieved in the percentage of time during which the concentration exceeded the MIC.

Cefazolin

Subcutaneous tissue

10.1055/s-0039-1695780

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Citations (2)

Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells: Inhibition of ribonucleotide reductase activity

Oncology Reports (2008)

Walter Jaeger Monika Fritzer‐Szekeres Thomas Szekeres Thomas Erker Norbert Handler

Ribonucleotide reductase

Propidium iodide

Clonogenic assay

10.3892/or.19.6.1621

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Citations (38)

Pharmacists' participation in research: a case of trying to find the time

International Journal of Pharmacy Practice (2010)

Kosta Cvijovic Heather Boon Walter Jaeger Sunita Vohra

Abstract Objective The objective of this case study was to explore how pharmacists involved in the Pharmacy Study Of Natural Health Product Adverse Reactions (SONAR) project perceived the barriers and facilitators to participating in clinical research. Methods A total of 19 semi-structured interviews were completed with pharmacy staff members who had recently completed data collection in the SONAR study which involved asking patients if they had experienced any unwanted effects while taking natural products. Other data sources included detailed field notes and interviews with SONAR researchers. Basic content analysis with multiple coders was used to analyse the data and triangulation was used to highlight areas of consistency and contrasting view points across the data types. Key findings None of the participating pharmacies was able to collect as much data as expected by the SONAR team. Lack of time was stated as the main reason why pharmacy staff had trouble with the data collection. However, observational data and detailed probing in interviews confirmed that data collection itself took very little time (seconds per patient). Lack of time was provided as a socially acceptable excuse that masked deeper issues related to fears associated with challenges modifying established work routines and perceived lack of value associated with research participation. Conclusion To successfully engage pharmacists in practice-based natural health product research it is necessary to establish the direct and indirect benefits of participation because those that believe in the value of the research will make the time for participation.

Value (mathematics)

10.1111/j.2042-7174.2010.00067.x

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Citations (37)

A resveratrol analog termed 3,3′,4,4′,5,5′-hexahydroxy-trans-stilbene is a potent HIV-1 inhibitor

Journal of Medical Virology (2015)

Ying-Shan Han Peter K. Quashie Thibault Mésplède Hongtao Xu Yudong Quan

HIV resistance to current anti-HIV drugs and drug toxicity have created a need for new anti-HIV agents. We have examined and characterized a synthetic resveratrol analog, termed 3,3',4,4',5,5'-hexahydroxy-trans-stilbene (M8), for potential anti-HIV activity. Here, we demonstrate that M8 possesses potent anti-HIV activity against several HIV variants with EC50 values in the low μM range. M8 was shown to act at a very early step of HIV entry prior to fusion to host cells. These results demonstrate that this novel resveratrol derivative possesses potent anti-HIV-1 activity and may have a mechanism of action that is different from current anti-HIV-1 drugs including entry inhibitors. Further structure-guided design might lead to the development of newer improved resveratrol derivatives that could have value either in therapy or as microbicides to prevent the sexual transmission of HIV-1.

Sexual transmission

Mechanism of Action

EC50

10.1002/jmv.24271

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Citations (15)

A Tool for Rapid Identification of Potential Herbal Medicine—Drug Interactions

Canadian Pharmacists Journal / Revue des Pharmaciens du Canada (2009)

Kosta Cvijovic Heather Boon Joanne Barnes Jayna Brulotte Walter Jaeger

Identification

10.3821/1913-701x-142.5.224a

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