Bogdan Procopeț

Iuliu Hațieganu University of Medicine and Pharmacy

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HȘ

Horia Ștefănescu

Institutul Regional de Gastroenterologie Prof. Dr. Octavian Fodor

Marcel Tanţău

Iuliu Hațieganu University of Medicine and Pharmacy

Oana Nicoară-Farcău

Iuliu Hațieganu University of Medicine and Pharmacy

Virginia Hernández–Gea

Universitat de Barcelona

Christophe Bureau

Université Toulouse III - Paul Sabatier

Juan Carlos García‐Pagán

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Annalisa Berzigotti

University Hospital of Bern

Joan Genescà

Universitat Autònoma de Barcelona

Petra Fischer

Iuliu Hațieganu University of Medicine and Pharmacy

Massimo Primignani

University of Milan

Cooperative Institutions

Iuliu Hațieganu University of Medicine and Pharmacy

125

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

105

Inserm

Institutul Regional de Gastroenterologie Prof. Dr. Octavian Fodor

Universitat de Barcelona

European Foundation for the Study of Chronic Liver Failure

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

Instituto de Salud Carlos III

Assistance Publique – Hôpitaux de Paris

Hospital Clínic de Barcelona

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Validation of the new proposed histological criteria for the diagnosis of porto-sinusoidal vascular disease in a single tertiary center

Journal of Hepatology (2020)

Oana Nicoară-Farcău Rusu Ioana Iulia Flueraru Horia Ștefănescu Marcel Tanţău

Center (category theory)

Tertiary care

Single Center

10.1016/s0168-8278(20)31577-4

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Citations (0)

Noninvasive tools and risk of clinically significant portal hypertension and varices in compensated cirrhosis: The “Anticipate” study

Hepatology (2016)

Juan G. Abraldeṣ Christophe Bureau Horia Ștefănescu Salvador Augustín Michael Ney

In patients with compensated advanced chronic liver disease (cACLD), the presence of clinically significant portal hypertension (CSPH) and varices needing treatment (VNT) bears prognostic and therapeutic implications. Our aim was to develop noninvasive tests-based risk prediction models to provide a point-of-care risk assessment of cACLD patients. We analyzed 518 patients with cACLD from five centers in Europe/Canada with paired noninvasive tests (liver stiffness measurement [LSM] by transient elastography, platelet count, and spleen diameter with calculation of liver stiffness to spleen/platelet score [LSPS] score and platelet-spleen ratio [PSR]) and endoscopy/hepatic venous pressure gradient measurement. Risk of CSPH, varices, and VNT was modeled with logistic regression. All noninvasive tests reliably identified patients with high risk of CSPH, and LSPS had the highest discrimination. LSPS values above 2.65 were associated with risks of CSPH above 80%. None of the tests identified patients with very low risk of all-size varices, but both LSPS and a model combining TE and platelet count identified patients with very low risk (<5%) risk of VNT, suggesting that they could be used to triage patients requiring screening endoscopy. LSPS values of <1.33 were associated with a <5% risk of VNT, and 26% of patients had values below this threshold. LSM combined with platelet count predicted a risk <5% of VNT in 30% of the patients. Nomograms were developed to facilitate point-of-care risk assessment.A significant proportion of patients with a very high risk of CSPH, and a population with a very low risk of VNT can be identified with simple, noninvasive tests, suggesting that these can be used to individualize medical care. (Hepatology 2016;64:2173-2184).

Transient elastography

Nomogram

10.1002/hep.28824

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Citations (303)

Are presepsin and resistin better markers for bacterial infection in patients with decompensated liver cirrhosis?

Digestive and Liver Disease (2019)

Petra Fischer Crina Grigoras A. Bugariu Oana Nicoară-Farcău Horia Ștefănescu

Resistin

Procalcitonin

Spontaneous bacterial peritonitis

Clinical Significance

10.1016/j.dld.2019.05.025

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Citations (23)

Proton pump inhibitors increase the risk for hepatic encephalopathy in patients with cirrhosis and ascites

Journal of Hepatology (2017)

Daniela Matei Sergiu Pașca A. David Bogdan Procopeț Horia Ștefănescu

Hepatic Encephalopathy

10.1016/s0168-8278(17)30542-1

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Citations (3)

Respiratory infection in patients with cirrhosis and acute varicealbleeding on antibiotic prophylaxis: A multicenter observational study of 2138 patients

Jorge Martínez Luís Téllez Virginia Hernández–Gea Bogdan Procopeț Álvaro Giráldez-Gallego

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Antiplatelet Prophylaxis Reduces the Risk of Early Hepatic Artery Thrombosis Following Liver Transplantation in High-Risk Patients

Transplant International (2024)

Iulia Minciună Jeroen de Jonge Caroline den Hoed Raoel Maan Wojciech G. Polak

The prevention of hepatic artery thrombosis (HAT) is pivotal for graft survival immediately after liver transplantation (LT). This study aimed to identify risk factors (RF) for early HAT (eHAT) and assess the benefit of antiplatelet prophylaxis (AP). This retrospective single-center study included 836 adult patients who underwent LT between 2007 and 2022. AP was administered for 3 months in N = 127 patients for surgical reasons. In total, 836 patients underwent LT, of whom 5.5% developed eHAT. In multivariable analysis, arterial anastomotic redo (aHR = 4.33), arterial reconstruction (aHR = 3.72) and cryptogenic liver cirrhosis (aHR = 4.25) were independent RFs for eHAT and AP appeared to be protective (aHR = 0.18). Indeed, in patients with at least one RF who received AP (RF+AP+, n = 94), the eHAT rate was significantly lower (3.2% vs. 21.3%,

10.3389/ti.2024.13440

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Corrigendum to ‘Baveno VII – Renewing consensus in portal hypertension’ [J Hepatol (2022) 959-974]

Journal of Hepatology (2022)

Roberto de Franchis Jaime Bosch Guadalupe García–Tsao Thomas Reiberger Cristina Ripoll

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Section (typography)

10.1016/j.jhep.2022.03.024

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Citations (9)

Liver International (2023)

Ares Villagrasa Virginia Hernández–Gea Ramón Bataller Álvaro Giráldez Gallego Bogdan Procopeț

Abstract Background & Aims Alcohol‐related hepatitis (AH) encompasses a high mortality. AH might be a concomitant event in patients with acute variceal bleeding (AVB). The current study aimed to assess the prevalence of AH in patients with AVB and to compare the clinical outcomes of AH patients to other alcohol‐related liver disease (ALD) phenotypes and viral cirrhosis. Methods Multicentre, observational study including 916 patients with AVB falling under the next categories: AH ( n = 99), ALD cirrhosis actively drinking (d‐ALD) ( n = 285), ALD cirrhosis abstinent from alcohol (a‐ALD) ( n = 227) and viral cirrhosis ( n = 305). We used a Cox proportional hazards model to calculate adjusted hazard ratio (HR) of death adjusted by MELD. Results The prevalence of AH was 16% considering only ALD patients. AH patients exhibited more complications. Forty‐two days transplant‐free survival was worse among AH, but statistical differences were only observed between AH and d‐ALD groups (84 vs. 93%; p = 0.005), when adjusted by MELD no differences were observed between AH and the other groups. At one‐year, survival of AH patients (72.7%) was similar to the other groups; when adjusted by MELD mortality HR was better in AH compared to a‐ALD (0.48; 0.29–0.8, p = 0.004). Finally, active drinkers who remained abstinent presented better survival, independently of having AH. Conclusions Contrary to expected, AH patients with AVB present no worse one‐year survival than other patients with different alcohol‐related phenotypes or viral cirrhosis. Abstinence influences long‐term survival and could explain these counterintuitive results.

Liver disease

Alcoholic Hepatitis

10.1111/liv.15606

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Citations (6)

Non-invasive measurement of HVPG using graph analysis of dynamic contrast-enhanced ultrasound: the CLEVER study

Journal of Hepatology (2018)

Annalisa Berzigotti Fabio Piscaglia Ivan Amat‐Roldan Rosa Gilabert Bogdan Procopeț

Contrast-enhanced ultrasound

Dynamic contrast

10.1016/s0168-8278(18)30372-6

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Citations (7)

Multiparametric ultrasound evaluation of liver fibrosis, steatosis, and viscosity in patients with chronic liver disease

Medical Ultrasonography (2024)

Iulia Minciună Madalina Gabriela Taru Andreea Fodor Oana Nicoară-Farcău Petra Fischer

This study assessed the effectiveness of three ultrasound-based techniques (2D-SWE.PLUS, Att.PLUS, Vi.PLUS) for non-invasive evaluation of liver fibrosis, steatosis, and inflammation in chronic liver disease (CLD) patients.Materials and methods: Involving 209 consecutive compensated CLD patients, the study compared these ultrasound methods from Aixplorerwith standard Vibration-controlled Transient Elastography (VCTE) and Controlled Attenuation Parameter (CAP) from Fibroscan, alongside non-invasive serological markers.

Steatosis

Liver steatosis

Chronic liver disease

Liver disease

10.11152/mu-4327

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Citations (1)