Wafa Arif

National University of Sciences and Technology

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Iqra Saleem

International Islamic University, Islamabad

Sohad A. Alshareef

University of Tabuk

Nosheen Fatima Rana

National University of Sciences and Technology

Tahreem Tanweer

National University of Sciences and Technology

Farid Menaa

California Medical Innovations Institute

Iqra Shafique

National University of Sciences and Technology

Hanadi A. Almukhlifi

University of Tabuk

Manal O. Al-Kattan

Jeddah University

Fatima S. Alaryani

Jeddah University

Aroosa Younis Nadeem

National University of Sciences and Technology

Cooperative Institutions

National University of Sciences and Technology

University of Tabuk

Jeddah University

International Islamic University, Islamabad

King Abdulaziz University

University of Newcastle Australia

University of Wah

University of Lahore

University of Veterinary and Animal Sciences

University of Poonch Rawalakot

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Antibacterial Activity of Dental Composite with Ciprofloxacin Loaded Silver Nanoparticles

Molecules (2022)

Wafa Arif Nosheen Fatima Rana Iqra Saleem Tahreem Tanweer Muhammad Bilal Khan

Resin composites have been widely used in dental restoration. However, polymerization shrinkage and resultant bacterial microleakage are major limitations that may lead to secondary caries. To overcome this, a new type of antibacterial resin composite containing ciprofloxacin-loaded silver nanoparticles (CIP-AgNPs) were synthesized. The chemical reduction approach successfully produced CIP-AgNPs, as demonstrated by FTIR, zeta potential, scanning electron microscopy, and ultraviolet-visible (UV-vis) spectroscopy. CIP-AgNPs were added to resin composites and the antibacterial activity of the dental composite discs were realized against Enterococcus faecalis, Streptococcus mutans, and the Saliva microcosm. The biocompatibility of modified resin composites was assessed and mechanical testing of modified dental composites was also performed. The results indicated that the antibacterial activity and compressive strength of resin composites containing CIP-AgNPs were enhanced compared to the control group. They were also biocompatible when compared to resin composites containing AgNPs. In short, these results established strong ground application for CIP-AgNP-modified dental composite resins.

Enterococcus faecalis

Silver nanoparticle

Biocompatibility

Dental composite

10.3390/molecules27217182

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Effectiveness of Se/ZnO NPs in Enhancing the Antibacterial Activity of Resin-Based Dental Composites

Materials (2022)

Iqra Saleem Nosheen Fatima Rana Tahreem Tanweer Wafa Arif Iqra Shafique

Biofilm formation in the resin-composite interface is a major challenge for resin-based dental composites. Using doped z nanoparticles (NPs) to enhance the antibacterial properties of resin composites can be an effective approach to prevent this. The present study focused on the effectiveness of Selenium-doped ZnO (Se/ZnO) NPs as an antibacterial nanofiller in resin composites and their impact on their mechanical properties. Pristine and Se/ZnO NPs were synthesized by the mechanochemical method and confirmed through UV-Vis Spectroscopy, FTIR (Fourier Transform Infrared) analysis, X-ray Diffraction (XRD) crystallography, Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDS), and Zeta analysis. The resin composites were then modified by varying concentrations of pristine and Se/ZnO NPs. A single species (S. mutans and E. faecalis) and a saliva microcosm model were utilized for antibacterial analysis. Hemolytic assay and compressive strength tests were also performed to test the modified composite resin's cytotoxicity and mechanical strength. When incorporated into composite resin, 1% Se/ZnO NPs showed higher antibacterial activity, biocompatibility, and higher mechanical strength when compared to composites with 1% ZnO NPs. The Se/ZnO NPs has been explored for the first time as an efficient antibacterial nanofiller for resin composites and showed effectiveness at lower concentrations, and hence can be an effective candidate in preventing secondary caries by limiting biofilm formation.

Resin composite

10.3390/ma15217827

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Citations (14)