Alexis L. Maule

Defense Health Agency

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Susan P. Proctor

U.S. Army Research Institute of Environmental Medicine

Kristin J. Heaton

United States Army

Michael D. McClean

Boston University

John F Ambrose

Defense Health Agency

Jun Maruta

Icahn School of Medicine at Mount Sinai

Matthew M. Scarpaci

University of Utah

Kristen Smith

University of Melbourne

Jamshid Ghajar

Stanford University

Ryan Steelman

U.S. Army Center for Health Promotion and Preventive Medicine

Julianna Kebisek

U.S. Army Center for Health Promotion and Preventive Medicine

Cooperative Institutions

Defense Health Agency

Boston University

U.S. Army Research Institute of Environmental Medicine

Centers for Disease Control and Prevention

United States Army

U.S. Army Center for Health Promotion and Preventive Medicine

National Center for Environmental Health

Harvard University

Defense Center for Public Health - Aberdeen

VA Boston Healthcare System

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Dynamic visuomotor synchronization: Quantification of predictive timing

Behavior Research Methods (2012)

Jun Maruta Kristin J. Heaton Elisabeth M. Kryskow Alexis L. Maule Jamshid Ghajar

Smooth pursuit

Stimulus (psychology)

10.3758/s13428-012-0248-3

Cite

Citations (35)

Permethrin exposure from wearing fabric-treated military uniforms in high heat conditions under varying wear-time scenarios

Journal of Exposure Science & Environmental Epidemiology (2019)

Susan P. Proctor Alexis L. Maule Kristin J. Heaton Bruce S. Cadarette Katelyn I. Guerriere

10.1038/s41370-019-0120-y

Cite

Citations (9)

Postural Sway and Exposure to Jet Propulsion Fuel 8 Among US Air Force Personnel

Journal of Occupational and Environmental Medicine (2013)

Alexis L. Maule Kristin J. Heaton Ema Rodrigues Kristen Smith Michael D. McClean

To determine whether short-term jet propulsion fuel 8 (JP-8) exposure is associated with balance measurements in JP-8-exposed air force personnel.As part of a larger neuroepidemiology study, balance tasks were completed by JP-8-exposed individuals (n = 37). Short-term JP-8 exposure was measured using personal breathing zone levels and urinary biomarkers. Multivariate linear regression analyses were conducted to examine the relationship between workday JP-8 exposure and postural sway.Balance control decreased as the task became more challenging. Workday exposure to JP-8, measured by either personal air or urinary metabolite levels, was not significantly related to postural sway. Increases in workday postural sway were associated with demographic variables, including younger age, being a current smoker, and higher body mass index.Results suggest that short-term workday JP-8 exposure does not significantly contribute to diminished balance control.

Jet fuel

10.1097/jom.0b013e31827db94b

Cite

Citations (7)

0018 Validation of a wearable real-time monitor of exposure to naphthalene

Occupational and Environmental Medicine (2014)

Susan P. Proctor John Snawder Belinda Johnson Alexis L. Maule Amanda Winkler

Objectives

Direct reading instruments are valuable tools for assessing exposure in the workplace. Adaption of such instruments to serve as valid and efficient tools to provide personal exposure data for environmental surveillance and occupational epidemiology studies fulfils a critical research need.

Method

A project is underway to validate new sensor technology that utilises native fluorescence of molecules excited by ultraviolet light with the goal of delivering laboratory-quality data for qualitative and quantitative analyses. The initial chemical of focus with this technology is naphthalene. The project is proceeding in two stages: independent laboratory validation and an exposure assessment field study, which is being conducted in two Phases: Phase I examines the degree to which the instrument serves as a sensor of naphthalene by assessing the concordance between measured personal air levels and those measured with conventional technologies e.g. active samplers; Phase II evaluates the validity of the instrument to serve as a dosimeter, correlating instrument-measured naphthalene levels in air with biological markers of exposure from skin, urine and exhaled breath.

Results

Independent laboratory evaluations indicate the instrument is accurate within accepted laboratory guidelines, when compared to standard gas chromatography methods. Results from the Phase I field study with US military personnel working with jet propulsion fuels (e.g., JP8 and jet A) as part of their regular work responsibilities support laboratory validation findings. Phase II data efforts are in progress.

Conclusions

This technology permits real-time evaluation of task-specific variations in personal naphthalene exposure levels, data that are currently not available with conventional active sampling processes.

Exposure Assessment

10.1136/oemed-2014-102362.2

Cite

Citations (1)

Degradation of Binocular Coordination during Sleep Deprivation

Frontiers in Neurology (2016)

Jianliang Tong Jun Maruta Kristin J. Heaton Alexis L. Maule Umesh Rajashekar

To aid a clear and unified visual perception while tracking a moving target, both eyes must be coordinated, so the image of the target falls on approximately corresponding areas of the fovea of each eye. The movements of the two eyes are decoupled during sleep, suggesting a role of arousal in regulating binocular coordination. While the absence of visual input during sleep may also contribute to binocular decoupling, sleepiness is a state of reduced arousal that still allows for visual input, providing a context within which the role of arousal in binocular coordination can be studied. We examined the effects of sleep deprivation on binocular coordination using a test paradigm that we previously showed to be sensitive to sleep deprivation. We quantified binocular coordination with the SD of the distance between left and right gaze positions on the screen. We also quantified the stability of conjugate gaze on the target, i.e., gaze-target synchronization, with the SD of the distance between the binocular average gaze and the target. Sleep deprivation degraded the stability of both binocular coordination and gaze-target synchronization, but between these two forms of gaze control the horizontal and vertical components were affected differently, suggesting that disconjugate and conjugate eye movements are under different regulation of attentional arousal. The prominent association found between sleep deprivation and degradation of binocular coordination in the horizontal direction may be used for a fit-for-duty assessment.

Sleep

Degradation

10.3389/fneur.2016.00090

Cite

Citations (8)

Effect of Environmental Temperature and Humidity on Permethrin Biomarkers of Exposure in U.S. Soldiers Wearing Permethrin-Treated Uniforms

American Journal of Tropical Medicine and Hygiene (2020)

Alexis L. Maule Kristin J. Heaton Bruce S. Cadarette Kathryn M. Taylor Katelyn I. Guerriere

Environmental factors, including high temperature and humidity, can influence dermal absorption of chemicals. Soldiers can be dermally exposed to permethrin while wearing permethrin-treated uniforms. This study aimed at examining the effects of high temperature and a combined high temperature and humid environment on permethrin absorption compared with ambient conditions when wearing a permethrin-treated uniform. Twenty-seven male enlisted soldiers wore study-issued permethrin-treated army uniforms for 33 consecutive hours in three different environments: 1) simulated high temperature (35°C, 40% relative humidity [rh]) (n = 10), 2) simulated high temperature and humidity (30°C, 70% rh) (n = 10), and 3) ambient conditions (13°C, 60% rh) (n = 7). Spot urine samples, collected at 21 scheduled time points before, during, and after wearing the study uniforms, were analyzed for permethrin exposure biomarkers (3-phenoxybenzoic acid, cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acid) and creatinine. Biomarker concentrations were 60–90% higher in the heat and combined heat/humidity groups (P < 0.001–0.022) than the ambient group. Also, the average daily permethrin dose, calculated 12 hours after removing the treated uniforms, was significantly higher in the heat (P = 0.01) and the heat/humidity (P = 0.03) groups than the ambient group. There were no significant differences in biomarker concentrations or computed average daily dose between the heat and the heat/humidity groups. Both hot and combined hot and humid environmental conditions significantly increased permethrin absorption in soldiers wearing permethrin-treated uniforms.

10.4269/ajtmh.19-0543

Cite

Citations (10)

Prevalence of selected underlying health conditions among active component Army service members with coronavirus disease 2019, 11 February-6 April 2020.

PubMed (2020)

Julianna Kebisek Lanna Forrest Alexis L. Maule Ryan Steelman John F Ambrose

The novel coronavirus (severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) is exhibiting widespread community transmission throughout most of the world. Previous reports have evaluated the risk of serious illness in civilians diagnosed with COVID-19; however, similar reports have not been compiled for the Army active component (AC) population. COVID-19 has been a reportable condition for the Department of Defense since 5 February 2020, and, as of the morning of 6 April, a total of 873 cases were reported to the Disease Reporting System internet from Army installations. Of these cases, a total of 219 (25.1%) were identified as Army AC service members. The majority of these cases did not require hospitalization (n=207; 94.5%). The most common comorbidities present in nonhospitalized cases included other chronic illnesses (43.5%), neurologic disorders (24.6%), and obesity (21.7%). Overall, 12 cases (5.5%) required hospitalization. Hospitalized cases had a history of obesity (58.3%), neurologic disorder (50.0%), other chronic illnesses (41.7%), and hypertension (25.0%). No comorbidities were present among 27.1% (n=56) of nonhospitalized cases and 25.0% (n=3) of hospitalized cases.

Pandemic

Coronavirus

Source

Cite

Citations (6)

Corrigendum to ‘JP8 exposure and neurocognitive performance among US Air Force personnel’ [Neurotoxicology 62 (2017) 170–180]

NeuroToxicology (2018)

Kristin J. Heaton Alexis L. Maule Kristen Smith Ema Rodrigues Michael D. McClean

Neurocognitive

10.1016/j.neuro.2018.07.007

Cite

Citations (0)