Edward L. Bennett

Missouri College

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Mark R. Rosenzweig

Blueprint Medicines (United States)

111

David Krech

University of California, Berkeley

Marian C. Diamond

University of California, Berkeley

James F. Flood

Geriatric Research Education and Clinical Center

Ann E. Orme

Virginia BioTechnology Research Park

Melvin Calvin

University of California, Berkeley

Hiromi Morimoto

Kitasato University

Marie Hébert

University of St Andrews

Murray E. Jarvik

Neurobehavioral Systems

Ann M. Hughes

Australian National University

Cooperative Institutions

University of California, Berkeley

University of Canterbury

Lawrence Berkeley National Laboratory

Tata Power Solar (India)

Illumina (United States)

University of California, Los Angeles

National Safety Council

Cornell University

University of California System

University of California, San Francisco

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Interhemispheric Effects of Cortical Lesions on Brain Biochemistry

Science (1960)

David Krech Mark R. Rosenzweig Edward L. Bennett

Unilateral lesions in the visual and somesthetic cortex of rat brain cause a slight but significant increase inc the cortical cholinesterase activity in the contralateral hemisphere. There is some indication of strain differences in this effect. No change in cholinesterase activity is found in the subcortical brain. These findings may be helpful in understanding mechanisms of interdependence among brain areas.

Cholinesterase

Brain cortex

10.1126/science.132.3423.352

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Citations (17)

Increases in cortical depth and glia numbers in rats subjected to enriched environment

The Journal of Comparative Neurology (1966)

Marian C. Diamond Fay Law Helen Rhodes Bernice Lindner Mark R. Rosenzweig

Abstract We have previously reported anatomical and chemical changes in the cerebral cortex of rats living in an enriched, stimulating environment. The present study includes additional histological measures such as more extensive depth measures, differential cell counts, and cell size measurements. Celloidin‐embedded, thionin‐stained sections of the visual cortex from environmentally enriched rats and their impoverished littermates were measured. Two methods for calculating cortical depths were used: one, with an ocular micrometer taking eight measures lateral to the elevation in the corpus callosum on each hemisphere; two, on enlarged photographs taking 51 measurements 2 mm apart on each hemisphere. With the ocular micrometer method the cortical depth of the enriched brains was 6.4% greater than the depth of the impoverished cortex. On the enlarged photographs the more medial depths in the enriched rats showed greater increases than the lateral depths. Overlapping photomicrographs were made of a medial cortical area 1.00 mm by 0.75 mm on each transverse section and were combined into one composite picture for each animal. Differential cell counts from the composite pictures were determined independently by two technicians. Results indicate a 14% (p<0.01) increase in glia among the enriched rats. No significant differences between enriched and impoverished groups were found in the perikarya and nuclear circumferences as measured with a planimeter from camera lucida drawings.

Cerebral hemisphere

10.1002/cne.901280110

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Citations (410)

Cerebral changes in rats exposed individually to an enriched environment.

Journal of Comparative and Physiological Psychology (1972)

Mark R. Rosenzweig Edward L. Bennett

This study is part of a continuing attempt to define the environmental conditions necessary to bring about cerebral differences between rodents exposed to enriched and impoverished environments.Rats placed singly in large enriched-environment cages for 2 hr.per day over a 30-day period were found to develop differences from home.:'cage controllittermates in weights. of brain sections and in brain-enzyme activities.These differences are small, however, unless the rat's interaction with the stimulus objects is facilitated; such priming can be accomplished by putting the rat in the enriched environment in the dark under the influence of an excitant drug.Social stimulation, which heretofore has always been included in the enriched condition, is now found not to be necessary.

10.1037/h0032978

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Citations (159)

Protein synthesis inhibition and memory for pole jump active avoidance and extinction

Pharmacology Biochemistry and Behavior (1977)

James F. Flood Murray E. Jarvik Edward L. Bennett Ann E. Orme Mark R. Rosenweig

Anisomycin

Extinction (optical mineralogy)

Protein synthesis inhibitor

10.1016/0091-3057(77)90013-2

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Citations (33)

Acetylcholine Metabolism and Behavior of Rats

Science (1959)

Mark R. Rosenzweig David Krech Edward L. Bennett

10.1126/science.129.3341.62.b

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Cerebral effects of differential experience in hypophysectomized rats.

Journal of Comparative and Physiological Psychology (1972)

Mark R. Rosenzweig Edward L. Bennett Marian C. Diamond

Enriched and impoverished environments have been demonstrated to.affect significantly brain chemistry and brain weights in rats.To test whether these effects might be mediated hormonally, three experiments were done on rats hypophysectomized at about 30 days and on normal controls.The 78 hypophysectomized rats retained were those with complete operations as verified by inspection of target organs and sella turcica.Environmental treatments lasted about 35-65 days of age.Among operates as among controls the enriched-environment rats showed significantly greater cortical weight, decreased cortical AChE/weight, and increased ChE/AChE.Thus these effects of"aifferential environment do not require mediation by hormones of the pituitary or those regulated by the pituitary.Hypophysectomized rats had significantly lower brain weights, lower cortical AChE/ weight, and great~r cortical ChE/ AChE than did controls.•

Hypophysectomy

10.1037/h0032527

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Citations (40)

ENVIRONMENTAL DETERMINANTS OF ACETYLCHOLINESTERASE AND CHOLINESTERASE ACTIVITIES IN RAT BRAIN

Elsevier eBooks (1966)

Mark R. Rosenzweig David Krech Edward L. Bennett Marian C. Diamond

Cholinesterase

10.1016/b978-0-08-011428-6.50086-0

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Citations (0)

Spectrophotometric analysis of RNA and DNA using cetyltrimethylammonium bromide