Christopher Whitfield

North Carolina Agricultural and Technical State University

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Muhammad Hanif Shiwani

Barnsley Hospital

Frederic A. Troy

University of California, Davis

Mohd Anwar

National Institutes of Health

Yang Liu

North Carolina Central University

Leslie A. MacDonald

National Institute for Occupational Safety and Health

J. Garner

Rotherham General Hospital

Joseph S. Lam

University of British Columbia

Charalambos Panayiotou Charalambous

University of Liverpool

Dorothy A. Adams

Organisation de Coopération et de Développement Economiques

Wal Baraza

University of Auckland

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Kinokuniya

232

Cambridge University Press

232

New York University Press

229

QIMR Berghofer Medical Research Institute

225

Hospital Universitário da Universidade de São Paulo

218

Leicester Royal Infirmary

Centre Hospitalier de Roubaix

Advisory Board Company (United States)

University of Leicester

Amsterdam University of Applied Sciences

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Optimal trauma care requires personnel and infrastructure to deliver optimal care.

Christopher Whitfield Muhammad Hanif Shiwani

Trauma care

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The modern management of splenic injury: a model for coordinated trauma services.

Christopher Whitfield Muhammad Hanif Shiwani J. Garner

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Letter to the Editor Optimal trauma care requires personnel and infrastructure to deliver optimal care

Christopher Whitfield Muhammad Hanif Shiwani

Trauma care

Patient Care

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Comparative analysis of flagellin sequences from Escherichia coli strains possessing serologically distinct flagellar filaments with a shared complex surface pattern

Journal of Bacteriology (1993)

Gary J. Schoenhals Christopher Whitfield

Escherichia coli morphotype E flagellar filaments have a characteristic surface pattern of short-pitch loops when examined by electron microscopy. Seven of the 50 known E. coli H (flagellar antigen) serotypes (H1, H7, H12, H23, H45, H49, and H51) produce morphotype E filaments. Polymerase chain reaction was used to amplify flagellin structural (fliC) genes from E. coli strains producing morphotype E flagellar filaments and from strains with flagellar filaments representing other morphotypes. A single DNA fragment was obtained from each strain, and the size of the amplified DNA correlated with the molecular mass of the corresponding flagellin protein. This finding and hybridization data suggest that these bacteria are monophasic. fliC genes from three E. coli serotypes (H1, H7, and H12) possessing morphotype E flagellar filaments were sequenced in order to assess the contribution of conserved flagellin primary sequence to the characteristic filament architecture. The H1 and H12 fliC sequences were identical in length (1,788 bp), while the H7 fliC sequence was shorter (1,755 bp). The deduced molecular masses of the FliC proteins were 60,857 Da (H1), 59,722 Da (H7), and 60,978 Da (H12). The H1, H7, and H12 flagellins demonstrated 98 to 99% identity over the amino-terminal region (190 amino acid residues) and 89% (H7) to 99% (H1 and H12) identity in the carboxy-terminal region (100 amino acid residues). The complete primary amino acid sequences for H1 and H12 flagellins differed by only 10 amino acids, accounting for previously reported serological cross-reactions. However, the central region of H7 flagellin had only 38% identity with H1 and H12 flagellins.The characteristic morphology of morphotype E flagellar filaments is therefore not dependent on a highly conserved primary sequence within the exposed central region. Comparison of morphotype E E. coli flagellins with those from E. coli K-12, Serratia marcescens, and several Salmonella serovars supported the established concept of highly conserved terminal regions flanking a variable central region.

Flagellin

10.1128/jb.175.17.5395-5402.1993

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Citations (51)

ANTHONY AND JOHN NASH; SHAKESPEARE'S LEGATEES

Notes and Queries (1967)

Christopher Whitfield

ANTHONY AND JOHN NASH; SHAKESPEARE'S LEGATEES Get access CHRISTOPHER WHITFIELD CHRISTOPHER WHITFIELD Broad Campden Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 14, Issue 4, April 1967, Pages 123–130, https://doi.org/10.1093/nq/14-4-123 Published: 01 April 1967

10.1093/nq/14-4-123

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Lipid Dynamics during the Spontaneous Reactivation of a Membranous Sialyltransferase Complex in Escherichia Coli K-235

Biophysical Journal (1982)

Frederic A. Troy Dorothy A. Adams Christopher Whitfield

Sialyltransferase

Dynamics

10.1016/s0006-3495(82)84612-2

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Surgical management of primary appendiceal malignancy

Colorectal Disease (2012)

Christopher Whitfield Salma Amin J. Garner

Primary appendiceal neoplasms are rare, with carcinoid being more common than carcinoma. Preoperative diagnosis is infrequent. We report a series of 24 primary appendiceal neoplasms treated over a 5-year period.All primary appendiceal neoplasms diagnosed in a university teaching hospital between April 2003 and June 2008 were identified from the prospective histopathology database. Patient records were reviewed for clinical, operative and pathological data.Fourteen carcinomas and 10 carcinoids were identified in the 5-year period. The former presented at median age 55.8 years with median symptom duration of 35 days, compared with 48 years and 3 days, respectively, for carcinoids. An abdominal mass was commoner in carcinomas (8/14 vs 1/10). Six patients with carcinoma underwent appendicectomy followed by completion right-hemicolectomy, two of whom had residual disease; seven underwent primary right-hemicolectomy and one had abscess drainage. Five patients with appendiceal carcinoma died of the disease during a median follow-up of 633 (256-1158) days. Six patients underwent appendicectomy for acute appendicitis, one had a primary right-hemicolectomy for a caecal mass. Three had a subsequent right-hemicolectomy for a high-risk carcinoid. An appendiceal carcinoid was an incidental finding in three right-hemicolectomy specimens removed for other indications. No metastases or deaths were recorded at median follow-up 451 (51-975) days.Appendiceal carcinomas follow a more protracted clinical course than carcinoids, which usually present as acute appendicitis. Caution is needed when diagnosing simple appendicitis in older patients with longer symptom duration, particularly if a mass is present. Patients with appendiceal carcinoma should be offered completion right-hemicolectomy. Carcinoma has a poor prognosis.

Hemicolectomy

Right hemicolectomy

Carcinoid tumors

10.1111/j.1463-1318.2012.03052.x

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Citations (31)

The Parentage and Connexions of William Combe of Warwick

Notes and Queries (1963)

Christopher Whitfield

Journal Article The Parentage and Connexions of William Combe of Warwick Get access Christopher Whitfield Christopher Whitfield Broad Campden Search for other works by this author on: Oxford Academic Google Scholar Notes and Queries, Volume 10, Issue 9, September 1963, Pages 323–326, https://doi.org/10.1093/notesj/10.9.323 Published: 01 September 1963

10.1093/notesj/10.9.323

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Surveillance of COVID-19 pandemic using social media

Christopher Whitfield Yang Liu Mohd Anwar

Coronavirus disease (COVID-19) pandemic has changed various aspects of people's lives and behaviors. At this stage, there are no other ways to control the natural progression of the disease than adopting mitigation strategies such as wearing masks, watching distance, and washing hands. Moreover, at this time of social distancing, social media plays a key role in connecting people and providing a platform for expressing their feelings. In this study, we tap into social media to surveil the uptake of mitigation and detection strategies, and capture issues and concerns about the pandemic. In particular, we explore the research question, "how much can be learned regarding the public uptake of mitigation strategies and concerns about COVID-19 pandemic by using natural language processing on Reddit posts?" After extracting COVID-related posts from the four largest subreddit communities of North Carolina over six months, we performed NLP-based preprocessing to clean the noisy data. We employed a custom Named-entity Recognition (NER) system and a Latent Dirichlet Allocation (LDA) method for topic modeling on a Reddit corpus. We observed that mask, flu, and testing are the most prevalent named-entities for "Personal Protective Equipment", "symptoms", and "testing" categories, respectively. We also observed that the most discussed topics are related to testing, masks, and employment. The mitigation measures are the most prevalent theme of discussion across all subreddits.

Pandemic

Social distance

10.1145/3459930.3469550

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Citations (9)

Reversal of loop ileostomy at barnsley hospital: Low morbidity but longer length of stay

International Journal of Surgery (2011)

Christopher Whitfield T Offori

Ileostomy

10.1016/j.ijsu.2011.07.329

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