Thai Yen Ly

Dalhousie University

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Sylvia Pasternak

Dalhousie University

Noreen M. Walsh

Queen Elizabeth II Health Sciences Centre

Michael D. Carter

Dalhousie University

Steve Doucette

Dalhousie University

Kirsten E. Fleming

Boston University

Peter Hull

John Brown University

Ryan DeCoste

Nova Scotia Health Authority

Daniel Gaston

Nova Scotia Health Authority

Peter Green

Dalhousie University

M. Godlewski

Polish Academy of Sciences

Cooperative Institutions

Dalhousie University

Queen Elizabeth II Health Sciences Centre

Nova Scotia Health Authority

Health Sciences Centre

Capital District Health Authority

University of Toronto

Izaak Walton Killam Health Centre

University of British Columbia

Sunnybrook Health Science Centre

Dermatopathologie Friedrichshafen

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Chylothorax and Chyloperitoneum

New England Journal of Medicine (2006)

Thai Yen Ly Robert Fowler

A 76-year-old man underwent elective repair of an abdominal aortic aneurysm, and in the subsequent eight weeks, exertional dyspnea, orthopnea, and abdominal pain developed. On physical examination, the patient was afebrile, and his vital signs were normal. There was a dull percussion note and decreased breath sounds over the right lower lung field. The abdomen was protuberant and diffusely tender. The serum triglyceride level was 1.21 mmol per liter (normal, <1.70 mmol per liter). A chest radiograph demonstrated a right pleural effusion (Panel A). Computed tomography of the abdomen revealed gross ascites containing particulate matter but no other abnormalities. Subsequent . . .

Chylothorax

10.1056/nejmc052422

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Citations (15)

The use of noninvasive imaging techniques in the diagnosis of melanoma: a prospective diagnostic accuracy study

Journal of the American Academy of Dermatology (2020)

Alexander Nikolas Maclellan Emma L. Price Pamela Publicover-Brouwer Kara Matheson Thai Yen Ly

10.1016/j.jaad.2020.04.019

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Citations (50)

RB1-deficient squamous cell carcinoma: the proposed source of combined Merkel cell carcinoma

Modern Pathology (2022)

Ryan DeCoste Noreen M. Walsh Daniel Gaston Thai Yen Ly Sylvia Pasternak

Merkel cell polyomavirus

Pathogenesis

10.1038/s41379-022-01151-2

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Citations (13)

Periocular invasive melanoma manifestation in a patient using bimatoprost: case report and literature review

Orbit (2021)

Adam P Deveau Flávia Nagel da Silva Thai Yen Ly Ahsen Hussain

Prostaglandin F2a analogs (PGAs) are considered efficacious in the first-line treatment of glaucoma. They have however been associated with a number of periocular side effects. We present a case of periocular hyperpigmentation and progression to lentigo maligna melanoma (LMM) in a patient using bimatoprost eye drops. We conducted a literature review regarding the etiology and pathophysiology of periocular pigmentation in this setting.A 71-year-old female Caucasian patient with open-angle glaucoma using bimatoprost exclusively in her right eye noticed an ipsilateral lower eyelid/upper cheek area dark lesion after commencing treatment. Examination demonstrated a heterogeneously pigmented lesion. Excisional biopsy demonstrated extensive lentigo maligna (melanoma in situ) with superficially invasive malignant melanoma in the lesion center. The patient underwent successful staged excision and reconstruction. Literature review has demonstrated case reports supporting periocular hyperpigmentation; however, there has been no description of progression to periocular lentigo maligna and melanoma in a patient using bimatoprost.

Bimatoprost

Lentigo maligna

10.1080/01676830.2021.1955392

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Citations (3)

Veritable Vascular Changes: Challenge

American Journal of Dermatopathology (2019)

Sheenagh George Peter Green Thai Yen Ly

*Dalhousie University Medical School, Halifax, Nova Scotia, Canada; †Department of Medicine, (Dermatology), Dalhousie University, Halifax, Nova Scotia, Canada; and ‡Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada. Correspondence: Sheenagh J. K. George, BSc, Dalhousie University Medical School, Suite 4-193 Dickson Building, 5820 University Avenue, Halifax, NS B3H2Y9, Canada (e-mail: [email protected]). The authors declare no conflicts of interest.

Nova scotia

George (robot)

Steering committee

10.1097/dad.0000000000001421

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Citations (0)

Pure versus combined Merkel cell carcinomas: immunohistochemical evaluation of cellular proteins (p53, Bcl-2, and c-kit) reveals significant overexpression of p53 in combined tumors

Human Pathology (2015)

Jonathan Lai Kirsten E. Fleming Thai Yen Ly Sylvia Pasternak M. Godlewski

Merkel cell polyomavirus

Merkel cell

Retinoblastoma protein

10.1016/j.humpath.2015.05.008

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Citations (29)

Support for p63 expression as an adverse prognostic marker in Merkel cell carcinoma: report on a Canadian cohort

Human Pathology (2014)

Kirsten E. Fleming Thai Yen Ly Sylvia Pasternak M. Godlewski Steve Doucette

Merkel cell

Univariate analysis

10.1016/j.humpath.2013.12.008

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Citations (45)

Recurrent and Fixed Neutrophilic Dermatosis Associated With Dasatinib

Journal of Cutaneous Medicine and Surgery (2018)

Joel Bergman Thai Yen Ly Margaret-Mary Keating Peter Hull

Background: Dasatinib is a tyrosine kinase inhibitor indicated for the treatment of chronic myeloid leukemia (CML). Skin rashes are common, occurring in about a quarter of patients treated, and are generally mild. The commonest rash is a keratosis pilaris-like eruption. A neutrophilic dermatosis has rarely been reported. Objective: We report a patient whose CML was successfully treated with dasatinib and who several years later developed episodes of a neutrophilic dermatosis recurring at the same sites. Conclusion: This report extends the clinical spectrum of neutrophilic dermatoses to include dasatinib-induced recurrent and fixed erythematous plaques.

Neutrophilic Dermatosis

10.1177/1203475418775663

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Citations (8)

Fine‐needle aspiration cytology of mammary fibroadenoma: A comparison of ThinPrep® and cytospin preparations

Diagnostic Cytopathology (2010)

Thai Yen Ly Penny J. Barnes Rebecca F. MacIntosh

Mammary fibroadenoma (FA) is a lesion frequently sampled and diagnosed by fine-needle aspiration (FNA). Accurate cytologic diagnosis of this common benign lesion is important as this can lead to non-surgical, conservative management when breast imaging and clinical examination are concordant. In most instances, a confident diagnosis of FA is possible because of a characteristic cytologic appearance that includes hypercellularity, large epithelial cell groups, staghorn epithelial configurations, stromal fragments, and numerous background stripped nuclei.1, 2 Nevertheless, FAs can be diagnostically challenging because of shared cytomorphologic features with other benign lesions and low-grade carcinoma. As such, FA is a well-recognized source of false results on FNA cytology.2-10 Furthermore, there are reports that newer thin layer cytopreparatory techniques, including the ThinPrep® (TP) system (Hologic Corp., Bedford, MA), alter the appearance of FA on FNA compared to conventional preparations and may compromise accurate cytologic diagnosis.11-13Diagn. Cytopathol. 2011;39:181–187. © 2010 Wiley-Liss, Inc.

Cytopathology

Liquid-based cytology

10.1002/dc.21358

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Citations (7)

Merkel cell carcinoma: an update

Human Pathology (2023)

Ryan DeCoste Michael D. Carter Thai Yen Ly Jennette R. Gruchy Anna P. Nicolela

Merkel cell polyomavirus

Dermatopathology

Merkel cell

Cell of origin

Histopathology

Clinical Significance

10.1016/j.humpath.2023.03.004

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Citations (9)