Larissa T. Bilaniuk

Children's Hospital of Philadelphia

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Co-Authors

Robert A. Zimmerman

Hospital of the University of Pennsylvania

139

Robert I. Grossman

New York University

Roger J. Packer

University of Vermont

David B. Hackney

Beth Israel Deaconess Medical Center

Herbert I. Goldberg

Hospital of the University of Pennsylvania

Derek A. Bruce

Children's National

Luis Schut

Children's Hospital of Philadelphia

H. I. Goldberg

Hospital of the University of Pennsylvania

Leslie N. Sutton

University of Pennsylvania

R. A. Zimmerman

Children's Hospital of Philadelphia

Cooperative Institutions

University of Pennsylvania

218

Children's Hospital of Philadelphia

203

Hospital of the University of Pennsylvania

118

Philadelphia University

105

Johns Hopkins University

Harvard University

National Cancer Institute

Massachusetts General Hospital

University of California, San Francisco

Children's National

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Computer tomography of traumatic intracerebral hemorrhagic lesions: The change in density and mass effect with time

Neuroradiology (1978)

R. A. Zimmerman Larissa T. Bilaniuk

Neuroradiology

Mass effect

10.1007/bf00395288

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Citations (18)

MR imaging of Lhermitte-Duclos disease: a case report.

American Journal of Neuroradiology (1989)

Ryan Smith Robert I. Grossman H. I. Goldberg David B. Hackney Larissa T. Bilaniuk

margins. Mass effect on the brainstem was clearly shown, as were the effects of the posterior fossa. Hydrocephalus was again noted. On the basis of the imaging studies a diagnosis of Lhermitte-Ouclos disease was postulated, although an atypical appearing glioma could not be entirely excluded. The patient underwent surgery for decompression and partial resection . The lesion at surgery appeared as a swoll en mass with associated flattened gyri and compressed su lci. The mass was diffi cult to distinguish from adjacent and deep normal cerebellum . This relatively hypovascular lesion had a poor cleavage plane, and it was resected in fragments up to a total of 3 x 3 cm. Pathology demonstrated a thickened molecular layer with hyper myelination, an abnormal granular layer, and an absence of Purkinje cells consistent with Lhermitte-Ouclos disease. The patient did well postoperatively with resolution of the head aches and disequilibrium; however, the left visual findings remain relatively unchanged and are probably secondary to a postcompres sive optic neuropathy.

Fluid-attenuated inversion recovery

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Citations (51)

Magnetic resonance imaging of pituitary lesions using 1.0 to 1.5 T field strength.

Radiology (1984)

Larissa T. Bilaniuk Robert A. Zimmerman Félix W. Wehrli Peter J. Snyder H I Goldberg

Six patients with pituitary abnormalities and three normal volunteers were evaluated by high field superconductive (1.0, 1.4, or 1.5 Tesla) magnetic resonance (MR) imaging, low field resistive (0.12 Tesla) MR imaging, and contrast-enhanced, high-resolution CT. Four macroadenomas, one microadenoma, and one empty sella were demonstrated. Their morphology and anatomic relationship to the visual pathway and the internal carotid and anterior cerebral arteries were best demonstrated by high field MR imaging. The low field resistive MR studies were least effective in showing the lesions.

Resistive touchscreen

10.1148/radiology.153.2.6484173

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Citations (53)

Risk of optic pathway glioma in children with neurofibromatosis type 1 and optic nerve tortuosity or nerve sheath thickening

British Journal of Ophthalmology (2015)

Marc H. Levin Gregory T. Armstrong J. Harris Broad Robert A. Zimmerman Larissa T. Bilaniuk

Background/aims

Optic nerve tortuosity and nerve and sheath thickening are observed on MRI in some patients with neurofibromatosis type 1 (NF-1). This study aimed to determine if tortuosity and thickening are associated with the development of optic pathway glioma (OPG) and subsequent vision loss.

Methods

Children with NF-1 who underwent brain MRI between 1992 and 2005, and had at least 1 year of subsequent visual acuity (VA) follow-up, were identified retrospectively. The baseline MRI was independently reviewed by three neuroradiologists for consensus assessment. Tortuosity was identified using validated operational criteria. Optic nerve and sheath thicknesses and VA at last follow-up were directly measured.

Results

Of 132 evaluable children, seven (5%) had tortuosity on baseline MRI. 20 subjects (15%) ultimately developed OPG at a median of 1.9 years (range 7 months–8.0 years) following the baseline MRI. Subjects with tortuosity were significantly more likely to develop OPG than those without tortuosity (57% vs 13%, p=0.01). In subjects who developed OPG, the prevalence of tumour-related vision loss was not significantly different between those with and without baseline tortuosity (14% vs 4%, p=0.28). No difference existed between mean baseline optic nerve (2.3 vs 2.2 mm) or sheath (5.2 vs 5.4 mm) thicknesses comparing subjects who did and did not develop OPG.

Conclusions

Optic nerve tortuosity at baseline is associated with OPG development among patients with NF-1, but does not predispose to aggressive OPG with associated vision loss. Neither nerve nor sheath thickening at baseline is associated with OPG development.

Tortuosity

10.1136/bjophthalmol-2015-306958

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Citations (31)

Evaluation of posterior fossa by imaging techniques

R. A. Zimmerman Larissa T. Bilaniuk

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Citations (0)

Magnetic Resonance Imaging of Pediatric Posterior Fossa Tumors

Pediatric Neurosurgery (1992)

Robert A. Zimmerman Larissa T. Bilaniuk Susan Rebsamen

MR detected abnormality in all 115 pediatric patients who subsequently had pathologically proven posterior fossa tumors. In 114, the initial magnetic resonance (MR) diagnosis was that of brain tumor. In 1, with less than 1-cm2 area of gadolinium enhancement, the significance of the initial finding was uncertain. Common posterior fossa tumor subgroups (brainstem gliomas, cerebellar astrocytomas, primitive neuroectodermal tumors, and ependymomas) have relatively consistent presentations on imaging studies. However, less common tumors mimic the MR appearance of more common ones, while common tumors may also have atypical appearances.

Posterior fossa

Ependymoma

Posterior cranial fossa

Abnormality

Brain tumor

10.1159/000120644

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Citations (29)

MR Identification of Bleeding Site in Subarachnoid Hemorrhage with Multiple Intracranial Aneurysms

Journal of Computer Assisted Tomography (1986)

David B. Hackney James E. Lesnick Robert A. Zimmerman Robert I. Grossman Herbert I. Goldberg

We report a case of multiple aneurysms with subarachnoid hemorrhage in which CT was inconclusive as to the source of bleeding and in which the angiographic criteria were misleading. Magnetic resonance demonstrated a focal subarachnoid hematoma adjacent to the ruptured aneurysm.

10.1097/00004728-198609000-00037

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Citations (37)

Contents, Vol. 10, 1983

Pediatric Neurosurgery (1983)

Achiah Eliash Abraham Roitman Moshe Karp Eli Reichental Riri S. Manor

10.1159/000120136

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A prospective, randomized, multicenter trial of amnioreduction vs selective fetoscopic laser photocoagulation for the treatment of severe twin-twin transfusion syndrome

American Journal of Obstetrics and Gynecology (2007)

Timothy M. Crombleholme David Shera Hanmin Lee Mark P. Johnson Mary E. D’Alton

Multicenter trial

Twin-to-twin transfusion syndrome

10.1016/j.ajog.2007.07.020

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Citations (173)

Early molecular detection of central nervous system relapse in a child with systemic anaplastic large cell lymphoma: Case report and review of the literature

Pediatric Blood & Cancer (2004)

Gregory T. Armstrong A Szállaśi Jaclyn A. Biegel Sheila Shurtleff Larissa T. Bilaniuk

Abstract We report a case of anaplastic large cell lymphoma (ALCL) with central nervous system relapse in an 11‐year‐old boy. The relapse was suspected on morphologic examination of the cytospin preparations of the cerebrospinal fluid (CSF) with a WBC of 10 cells/μl. CSF relapse was confirmed using immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and reverse transcriptase‐polymerase chain reaction (RT‐PCR) for abnormal ALK expression or gene structure. The patient developed large intracranial metastases, despite systemic, and intrathecal chemotherapy. This case demonstrates the feasibility of detecting ALCL in paucicellular CSF specimens and suggests that even low CSF involvement can herald massive parenchymal disease. © 2004 Wiley‐Liss, Inc.

Anaplastic large-cell lymphoma

Parenchyma

10.1002/pbc.20250

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Citations (5)