Journal Article A Certain Mutant Blocked in trans-4-Hydroxy-l-proline Formation from l-Proline during Neoviridogrisein Biosynthesis Get access Yasushi Okumura, Yasushi Okumura Central Research Laboratories, Sanraku-Ocean Co., Ltd., 9–1 Johnan 4-chome, Fujisawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Masahiro Onishi, Masahiro Onishi Central Research Laboratories, Sanraku-Ocean Co., Ltd., 9–1 Johnan 4-chome, Fujisawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Nobuo Nagato, Nobuo Nagato Central Research Laboratories, Sanraku-Ocean Co., Ltd., 9–1 Johnan 4-chome, Fujisawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Rokuro Okamoto, Rokuro Okamoto Central Research Laboratories, Sanraku-Ocean Co., Ltd., 9–1 Johnan 4-chome, Fujisawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Tomoyuki Ishikura Tomoyuki Ishikura Central Research Laboratories, Sanraku-Ocean Co., Ltd., 9–1 Johnan 4-chome, Fujisawa 251, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 47, Issue 5, 1 May 1983, Pages 1087–1092, https://doi.org/10.1080/00021369.1983.10865768 Published: 01 May 1983 Article history Received: 29 November 1982 Published: 01 May 1983
This study aimed to assess the long-term outcomes of radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Twenty-seven patients with Stage I gastric MALT lymphoma were treated with radiotherapy from 1999 to 2010. The median age was 65 years (range: 31-84). Fifteen patients were Helicobacter pylori-negative. Thirteen patients were treated with definitive radiotherapy alone. The other 14 patients who had refractory or residual disease following a prior treatment received salvage radiotherapy. The median dose of the radiotherapy was 30 Gy in 20 fractions (range: 30-39.5 Gy). The median follow-up period was 121 months (range: 8-176 months). The 5- and 10-year overall survival rates for all patients were 92% and 87%, respectively. No patients died from MALT lymphoma. Three patients died of other diseases at 8, 33 and 74 months after radiotherapy (myocardial infarction, pneumonia and hepatocellular carcinoma, respectively). No cases of local recurrence were observed during the follow-up period. There were no serious late gastric, liver or kidney complications during a median follow-up period of over 10 years. Two patients remain alive with distant metastases: a lung metastasis and an abdominal lymph node metastasis at 104 months and 21 months after radiotherapy, respectively. Excellent long-term local control was observed in patients with localized gastric MALT lymphoma after radiotherapy. However, lifelong follow-up should be conducted to detect cases of late recurrence, especially distant metastases.
Journal Article Irreversible Extrusion of the First Loop Facing the Matrix of the Bovine Heart Mitochondrial ADP/ATP Carrier by Labeling the Cys56 Residue with the SH-Reagent Methyl Methanethiosulfonate Get access Mitsuru Hashimoto, Mitsuru Hashimoto *Faculty of Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505 Search for other works by this author on: Oxford Academic PubMed Google Scholar Eyi Majima, Eyi Majima *Faculty of Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505†APRO Life Science InstituteKurosaki, Naruto 772-0001 Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Hatanaka, Takashi Hatanaka *Faculty of Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505 Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasuo Shinohara, Yasuo Shinohara *Faculty of Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505 Search for other works by this author on: Oxford Academic PubMed Google Scholar Masakatsu Onishi, Masakatsu Onishi *Faculty of Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505 Search for other works by this author on: Oxford Academic PubMed Google Scholar Satoru Goto, Satoru Goto *Faculty of Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505 Search for other works by this author on: Oxford Academic PubMed Google Scholar Hiroshi Terada Hiroshi Terada 2 *Faculty of Pharmaceutical Sciences, University ofTokushimaShomachi-1, Tokushima 770-8505 2 To whom correspondence should be addressed. Fax: +81-88-633-9511, E-mail:hterada@ph.tokushima-u.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 127, Issue 3, March 2000, Pages 443–449, https://doi.org/10.1093/oxfordjournals.jbchem.a022626 Published: 01 March 2000 Article history Received: 29 November 1999 Accepted: 15 December 1999 Published: 01 March 2000
To determine the most reliable predictor for pathologic complete response (pCR) in patients who underwent preoperative chemoradiotherapy and regional hyperthermia (HCRT) for rectal cancer.Thirty-six patients were enrolled. The local control status of the patients was assessed using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), magnetic resonance imaging (MRI), and colonoscopy before and after HCRT. The relationships between various parameters of these clinical examinations and pCR were analyzed.Ten (28%) patients achieved pCR. The accuracies of predicting pCR using FDG-PET/CT, MRI, and colonoscopy were 78%, 61%, and 75%, respectively. FDG-PET/CT was the only independent predictive modality for pCR (p=0.021). The maximum standardized uptake value (SUVmax) and SUVmax normalized to liver uptake (SLR) after HCRT showed the highest sensitivity (90%) and the decreasing rate of SUVmax and SLR demonstrated the highest specificity (89%) for pCR.SUVmax-based parameters of FDG-PET/CT after HCRT were the most reliable predictors for pCR.
Discretization errors due to the digitization of computed tomography images and the calculation grid are a significant issue in radiation therapy. Such errors have been quantitatively reported for a fixed multifield intensity-modulated radiation therapy using traditional linear accelerators. The aim of this study is to quantify the influence of the calculation grid size on the dose distribution in TomoTherapy. This study used ten treatment plans for prostate cancer. The final dose calculation was performed with "fine" (2.73 mm) and "normal" (5.46 mm) grid sizes. The dose distributions were compared from different points of view: the dose-volume histogram (DVH) parameters for planning target volume (PTV) and organ at risk (OAR), the various indices, and dose differences. The DVH parameters were used Dmax, D2%, D2cc, Dmean, D95%, D98%, and Dmin for PTV and Dmax, D2%, and D2cc for OARs. The various indices used were homogeneity index and equivalent uniform dose for plan evaluation. Almost all of DVH parameters for the "fine" calculations tended to be higher than those for the "normal" calculations. The largest difference of DVH parameters for PTV was Dmax and that for OARs was rectal D2cc. The mean difference of Dmax was 3.5%, and the rectal D2cc was increased up to 6% at the maximum and 2.9% on average. The mean difference of D95% for PTV was the smallest among the differences of the other DVH parameters. For each index, whether there was a significant difference between the two grid sizes was determined through a paired t-test. There were significant differences for most of the indices. The dose difference between the "fine" and "normal" calculations was evaluated. Some points around high-dose regions had differences exceeding 5% of the prescription dose. The influence of the calculation grid size in TomoTherapy is smaller than traditional linear accelerators. However, there was a significant difference. We recommend calculating the final dose using the "fine" grid size.
In 2021, Japan's medical expenses will exceed 45 trillion yen, and the shortage of doctors, especially in remote and mountainous areas, is becoming serious, making it difficult to maintain the medical system. We have conducted a study of 800 health consultation text data. We developed an on-premise health counseling LLM system by constructing a dialogue flow based on 800 health counseling text data. We conducted a Turing test of this system using 200 test data and verified its effectiveness with three medical professionals. The Turing test was a comparison experiment between this system and a conventional LLM system. The health counseling LLM infrastructure focuses on exercise guidance and analyzes gender, height, weight, body fat percentage, and muscle mass. While the accuracy of the conventional LLM system was 87.5%, this system showed a higher accuracy of 93.1%. Although telemedicine has been slow to spread in Japan, the introduction of a health consultation system using Personal Health Record and Large Language Models has the potential to reduce the burden on physicians. In the future, we aim to improve the accuracy of the system by using Japanese language and medical-specific evaluation scales.
