Galina Portnova

Institute of Higher Nervous Activity and Neurophysiology

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Olga Martynova

Institute of Higher Nervous Activity and Neurophysiology

Olga Sysoeva

Sirius University of Science and Technology

Ivan V. Skorokhodov

Pushkin State Russian language Institute

Elena V. Proskurnina

Research Centre for Medical Genetics

Anton Varlamov

Pushkin State Russian language Institute

ВВ

В. В. Подлепич

Burdenko Neurosurgery Institute

Alexey Ivanitsky

Institute of Higher Nervous Activity and Neurophysiology

Alina Tetereva

University of Otago

Aleksandra V. Maslennikova

Institute of Higher Nervous Activity and Neurophysiology

L. A. Mayorova

V.A. Negovsky Scientific Research Institute of General Reanimatology

Cooperative Institutions

Institute of Higher Nervous Activity and Neurophysiology

Russian Academy of Sciences

Lomonosov Moscow State University

National Research University Higher School of Economics

Pushkin State Russian language Institute

Moscow State University

Ministry of Health of the Russian Federation

Burdenko Neurosurgery Institute

Skolkovo Institute of Science and Technology

Sirius University of Science and Technology

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The Role of Midbrain in Perception of Tone Sequences and Speech: an Analysis of Individual Studies

Физиология человека (2023)

L. B. Oknina A. O. Kantserova D. I. Pitshelauri В. В. Подлепич Galina Portnova

Human speech is a complex combination of sounds, auditory events. To date, there is no consensus on how speech perception occurs. Does the brain react to each sound in the flow of speech separately, or are discrete units distinguished in the sound series, analyzed by the brain as one sound event. The pilot study analyzed the responses of the human midbrain to simple tones, combinations of simple tones (“complex” sounds), and lexical stimuli. The work is a description of individual cases obtained in the frame of intraoperative monitoring during surgical treatment of tumors of deep midline tumors of the brain or brain stem. The study included local-field potentials from the midbrain in 6 patients (2 women, 4 men). The S- and E-complexes that emerge at the beginning and end of the sound, as well as the S-complexes that emerge when the structure of the sound changes, were identified. The obtained data suggest that the selected complexes are markers of the primary coding of audio information and are generated by the structures of the neural network that provides speech perception and analysis.

Tone (literature)

10.31857/s0131164623600052

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Salivary Oxytocin and Antioxidative Response to Robotic Touch in Adults with Autism Spectrum Disorder

International Journal of Molecular Sciences (2023)

Galina Portnova Elena V. Proskurnina Ivan V. Skorokhodov S. V. Sokolova Alexey Semirechenko

Individuals with ASD are known to have a tendency to have tactile sensory processing issues that could be associated with their impairment as regards social communication. The alterations in tactile processing in autistic subjects are usually accompanied by hypersensitivity and other unpleasant emotions induced by tactile contact. In our study, we investigated the impact of the velocity and the force of a tactile stroke received impersonally by a custom-built robotic device. A total of 21 adults with ASD and 22 adults from a control group participated in our study. The participants’ responses were assessed according to subjective scales, EEG changes, and the dynamics of saliva antioxidants and oxytocin. It was found that the oxytocin level was significantly lower in subjects with ASD but increased after tactile stimulation. However, contrary to expectations, the increase in the oxytocin level in the target group negatively correlated with the subjective pleasantness of tactile stimulation and was probably associated with a stress-induced effect. The basic levels of antioxidants did not differ between the TD and ASD groups; however, these had significantly increased in individuals with ASD by the end of the study. The EEG findings, which revealed enhanced antioxidant levels, contributed to the relief of the cognitive control during the study.

Sensory stimulation therapy

Sensory Processing

10.3390/ijms241512322

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Abnormalities in EEG microstates among individuals with major depression and obsessive- compulsive disorder

Research Square (Research Square) (2024)

Ekaterina Proshina Galina Portnova Guzal Khayrullina Emma Bainbridge Olga Martynova

Abstract Electroencephalogram microstate analysis is a valuable tool for studying the rapid dynamics of large-scale brain networks. Research has shown that microstate changes are associated with mental disorders, particularly major depressive disorder (MDD) and obsessive-compulsive disorder (OCD). Despite their frequent comorbidity and symptomatic overlap, MDD and OCD often require different treatment approaches. By analyzing the patterns of microstates in individuals with OCD, MDD and a control group, we aim to improve our understanding of the neural pathways involved in these disorders. Resting state EEG data were collected from 32 individuals diagnosed with MDD, 26 individuals with OCD and 40 healthy controls. The results showed that the duration, occurrence and coverage of microstate C were significantly higher in the OCD group than in the MDD group. Conversely, both the duration and coverage of microstate D were lower in the OCD group than in MDD and controls. A negative correlation was found between Beck Depression Inventory scores and the duration and coverage of microstate A specifically within the OCD group. Our study revealed that the microstate patterns observed in MDD and OCD were markedly distinct, with microstates A, C, and D emerging as the most indicative in the context of OCD.

Ministate

Depression

10.21203/rs.3.rs-5319152/v1

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Fmri study of changes in large-scale brain networks during affective touch

The European Physical Journal Special Topics (2024)

Vladimir Khorev Galina Portnova А. Б. Кушнир L. A. Mayorova

10.1140/epjs/s11734-024-01330-z

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The Dynamics of Resting-State EEG and Salivary Trace Elements in Patients with Obsessive-Compulsive Disorder

ACS Chemical Neuroscience (2024)

Galina Portnova Guzal Khayrullina Ivan V. Mikheev Sofiya M. Byvsheva Elena V. Proskurnina

The study of salivary microelements and their neurophysiological and behavioral correlates in patients with obsessive-compulsive disorder (OCD) is a pressing issue in modern psychiatry, which, however, lacks adequate research at this time. In this study, we tested the dynamics of behavioral parameters, resting-state electroencephalogram (EEG), and salivary iron, copper, manganese, magnesium, and zinc in 30 healthy volunteers and 30 individuals with OCD before and after an emotional antisaccade task. The eye-movement data served as a measure of behavioral performance. Our research revealed consistently higher manganese concentrations in the OCD group compared to healthy volunteers associated with a higher EEG ratio of amplitude transformation and symptom severity. The dynamics of salivary microelements and resting-state EEG, possibly influenced by cognitive and emotional load during the anticsaccade task, differed between groups. In healthy volunteers, there was a decrease in salivary iron level with an increase in high-frequency power spectral density of EEG. The OCD group showed a decrease in salivary copper with an increased Hjorth mobility of EEG.

10.1021/acschemneuro.3c00697

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EMOTIONAL PERCEPTION IN COMATOSE PATIENTS

Neuroscience for Medicine and Psychology (2021)

Galina Portnova

10.29003/m2284.sudak.ns2021-17/307-308

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Development and Initial Validation of the Russian Version of the RAADS-14: A Self-Report Questionnaire to Assess Autistic Traits

European Journal of Investigation in Health Psychology and Education (2023)

Ivan V. Skorokhodov Ksenia P. Radygina Elena Skorokhodova Svetlana P. Firsova Galina Portnova

Autism is a relatively common neurodevelopmental condition that affects social communication and behavior, affecting the overall quality of life. The prevalence of autism is constantly increasing, but timely diagnosis allows for effective treatment. The aim of our research was to construct a Russian version of the RAADS-14, a brief self-report questionnaire originally designed for autism screening, and to perform its initial validation to provide a reference point in developing autism self-assessment tools for the Russian-speaking population. Psychometric properties of the RAADS-14 Rus were evaluated on a sample of 1724 participants, including a general sample of non-psychiatric young adults (n = 794) and adults with clinically established ASD (n = 49); a brief Russian inventory assessing Big Five personality traits (FFQ) was administered to a part of the sample (n = 364) to provide the first assessment of criterion validity. Confirmatory factor analysis of the RAADS-14 Rus confirmed the factor structure of the original Swedish version yielding acceptable fit indices. The discriminating properties were substantially worse than in the original study. The correlations between the RAADS-14 Rus domain scores and the Big Five factors were similar to previously obtained findings. Overall, the results suggest that the RAADS-14 Rus can be used as a screening tool for ASD in adults with proper caution and considering its discriminating properties.

Sample (material)

Autistic traits

10.3390/ejihpe13110188

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Citations (1)

ЭЭГ-корреляты особенностей восприятия тактильных стимулов у детей с расстройствами аутистического спектра

Современные технологии в медицине (2019)

Galina Portnova Francis McGlone О. А. Танькина Ivan V. Skorokhodov Igor L. Shpitsberg

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EEG resting state before sleep