Baogang Peng

Sun Yat-sen University

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Shunli Shen

Sun Yat-sen University

Ming Kuang

The First Affiliated Hospital, Sun Yat-sen University

Shaoqiang Li

First Affiliated Hospital of Guangzhou Medical University

Lijian Liang

The First Affiliated Hospital, Sun Yat-sen University

Yunpeng Hua

Sun Yat-sen University

Jiaming Lai

Sun Yat-sen University

Dongming Li

Hebei Normal University

Sui Peng

The First Affiliated Hospital, Sun Yat-sen University

Shuling Chen

The First Affiliated Hospital, Sun Yat-sen University

Minghui He

South China University of Technology

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Sun Yat-sen University

322

The First Affiliated Hospital, Sun Yat-sen University

254

Sun Yat-sen University Cancer Center

Southern Medical University

Chinese Academy of Medical Sciences & Peking Union Medical College

Fudan University

Huazhong University of Science and Technology

Peking University

Chinese Academy of Sciences

Sichuan University

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Is Salvage Liver Resection Necessary for Initially Unresectable Hepatocellular Carcinoma Patients Downstaged by Transarterial Chemoembolization? Ten Years of Experience

The Oncologist (2016)

Yingqiang Zhang Guihua Huang Yu Wang Li‐Jian Liang Baogang Peng

Abstract Introduction. This study evaluated long-term outcomes of salvage surgery as additional therapy following downstaging of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) in patients with initially unresectable HCC. Methods. A retrospective analysis was performed of 831 consecutive patients with unresectable HCC who underwent TACE as initial treatment between June 2004 and December 2014. Of these, 82 patients with downstaged resectable HCC were enrolled in this study: 43 received salvage surgery (S group) and the remaining 39, who refused salvage resection, were the control group (T group). The primary endpoint was overall survival (OS). Results. The median OS in the S and T groups was 49 and 31 months, respectively (p = .027). The 2-, 4-, and 5-year survival rates were 93%, 47%, and 26% in the S group and 74%, 18%, and 10% in the T group, respectively (p = .019). Treatment modality (hazard ratio [HR], 0.337; 95% confidential interval [CI], 0.184–0.616; p < .001) and response to TACE (complete vs. partial; HR, 3.154; 95% CI, 1.709–5.822; p < .001) were independent prognostic factors for survival. The median OS for patients in the complete response and partial response (PR) subgroups was 50 and 49 months, respectively, in the S group and 54 and 24 months, respectively, in the T group (p = .699 and p < .001, respectively). The median OS for HCC patients with macroscopic vascular invasion (MVI) was 58 and 30 months in the S and T groups, respectively (p = .024). Conclusion. Salvage surgery after downstaging of unresectable HCC had a survival benefit only for patients with MVI or a PR to TACE.

Salvage Surgery

Clinical endpoint

Salvage therapy

10.1634/theoncologist.2016-0094

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Citations (70)

Correction: Numb Promotes Cell Proliferation and Correlates with Poor Prognosis in Hepatocellular Carcinoma

PLoS ONE (2022)

Jian Wu Shunli Shen Bin Chen Jing Nie Baogang Peng

[This corrects the article DOI: 10.1371/journal.pone.0095849.].

NUMB

10.1371/journal.pone.0265938

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YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice

American Journal Of Pathology (2021)

Xinjun Lu Baogang Peng Ge Chen Giovanni Mario Pes Silvia Ribback

10.1016/j.ajpath.2021.05.017

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Citations (15)

Table S5 from The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas

Manling Huang Minghui He Yu Guo Heping Li Shunli Shen

<p>Table S5 shows detailed information of structure variations in the six HCC patients with WGS analysis.</p>

Immune checkpoint

Table (database)

10.1158/1078-0432.22476084.v1

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Table S5 from The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas

Manling Huang Minghui He Yu Guo Heping Li Shunli Shen

<p>Table S5 shows detailed information of structure variations in the six HCC patients with WGS analysis.</p>

Table (database)

Immune checkpoint

10.1158/1078-0432.22476084

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Citations (0)

Nomogram to Predict Survival of Patients With Recurrence of Hepatocellular Carcinoma After Surgery

Clinical Gastroenterology and Hepatology (2017)

Wei He Baogang Peng Yunqiang Tang Junpin Yang Yun Zheng

Nomogram

Concordance

Liver Cancer

10.1016/j.cgh.2017.12.002

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Citations (56)

Arterial infusion of 5-fluorouracil combined with subcutaneous injection of pegylated interferon alpha-2b in treating unresectable hepatocellular carcinoma with portal vein tumor thrombus

Medical Oncology (2015)

Jian Wu Wenjin Huang Huanyu Wang Yafeng Wang Baogang Peng

Pegylated interferon

Portal vein thrombosis

Subcutaneous injection

Hematology

10.1007/s12032-015-0491-4

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Citations (3)

Elevated preoperative peripheral blood monocyte count predicts poor prognosis for hepatocellular carcinoma after curative resection

BMC Cancer (2014)

Shunli Shen Shunjun Fu Xiongqing Huang Bin Chen Ming Kuang

Peripheral blood monocyte count is an easily assessable parameter of systemic inflammatory response. The aim of this study was to determine whether monocyte count was prognostic in hepatocellular carcinoma (HCC) following hepatic resection. We retrospectively reviewed 351 patients with HCC treated with hepatic resection from 2006 to 2009. Preoperative absolute peripheral monocyte count, demographics, and clinical and pathological data were analyzed. On univariate and multivariate analysis, elevated monocyte counts (≥545/mm3), tumor size ≥5 cm, non-capsulation, and multiple tumors were associated with poor disease-free survival (DFS) and overall survival (OS). The 1-, 3- and 5-year DFS rates were 58%, 41% and 35%, respectively, for patients with monocyte counts <545/mm3, and 36%, 23% and 21% for patients with monocyte counts ≥545/mm3. Correspondingly, the 1-, 3- and 5-year OS rates were 79%, 53% and 46% for monocyte counts <545/mm3, and 64%, 36% and 29% for monocyte counts ≥545/mm3. Subgroup analysis indicated that DFS after hepatic resection in hepatitis B virus (HBV)-infected patients was significantly better in those with a peripheral blood monocyte counts <545/mm3, but it did not differ between patients without HBV infection. In addition, DFS was significantly better for patients with a peripheral blood monocyte count <545/mm3, whether or not cirrhosis was present. Patients with elevated monocyte counts tended to have larger tumors. Elevated preoperative monocyte count is an independent predictor of worse prognosis for patients with HCC after hepatic resection, especially for those with HBV infection. Postoperative adjuvant treatment might be considered for patients with elevated preoperative monocyte counts.

Monocyte

Surgical oncology

Univariate analysis

10.1186/1471-2407-14-744

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Citations (36)

Identification of Max binding protein as a novel binding protein of Nck1 and characterization of its role in inhibiting human liver cancer SK-HEP-1 cells.

PubMed (2012)

Qi Zhou Tao Huang Yafeng Wang Kun-sun Zhang Dong Chen

The tendency of tumor cells to disperse throughout the liver is a distinct feature of hepatocellular carcinoma (HCC). Nck family adaptor proteins function to regulate actin cytoskeletal reorganization that leads to cell motility. We previously found that Max binding protein (MNT) was differentially expressed in HCC, and interacted with Nck1 by 2-DE. MNT is a protein member of the Myc/Max/Mad network which plays roles in cell proliferation, differentiation, and death. We investigated the effects of MNT on migration of human liver cancer SK-HEP-1 cells to study the migration regulatory role of MNT in HCC cells.Interaction between MNT and Nck1 was further validated in hepatoma cells by GST-pull down assay and immunoprecipitation. siRNAs specific to MNT (MNT siRNA) were used to knockdown MNT expression. Western blotting, transwell assay were used to determine the migration potential of cells.Interaction between MNT and Nck1 was validated in hepatoma cells. MNT knockdown promoted the migration of human liver cancer SK-HEP-1 cells (P < 0.01).The results suggest that MNT, via interaction with Nck1, inhibits hepatoma cell migration.

Liver Cancer

Immunoprecipitation

Liver cell

Source

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Citations (4)

Prognostic value of preoperative serum gamma-glutamyltranspeptidase in patients with hepatocellular carcinoma after hepatectomy

Tumor Biology (2015)

Shunjun Fu Zhiyong Guo Shaoqiang Li Ming Kuang Wenjie Hu

Gamma-glutamyltranspeptidase (γ-GGT), an oxidative stress marker, is correlated with inflammation in the extracellular hepatic microenvironment. This study aimed to evaluate the prognostic value of serum γ-GGT levels in patients with hepatocellular carcinoma (HCC) after hepatectomy. Three hundred and eight patients who underwent hepatic resection for HCC were included in the study. Preoperative serum γ-GGT levels, as well as demographic, clinical, and pathologic data, were analyzed. The optimal cutoff value of γ-GGT was 88 U/L. All patients were divided into γ-GGT ≤ 88 U/L group (n = 146) and γ-GGT > 88 U/L group (n = 162). The disease-free survival (DFS) and overall survival (OS) rates of patients in the γ-GGT > 88 U/L group were poorer than those in γ-GGT ≤ 88 U/L group. Preoperative serum γ-GGT levels, associating with gender, HBsAg status, tumor size, capsulation, tumor number, and vascular invasion, was an independent prognostic predictor of disease-free survival [hazard ratio (HR) = 1.616; 95 % confidence interval (CI), 1.223-2.135; P = 0.001] and overall survival (HR = 2.043; 95 % CI, 1.509-2.766; P < 0.001). Furthermore, γ-GGT was also associated with DFS and OS in small HCC (tumor size ≤5 cm) and alpha-fetoprotein (AFP) ≤ 200 ng/mL subgroup. In conclusion, γ-GGT is a promising and reliable prognostic biomarker in HCC patients after hepatic resection, especially for patients with small HCC or AFP ≤ 200 ng/mL.

Gamma-glutamyltransferase

Alpha-fetoprotein

10.1007/s13277-015-4136-1

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Citations (23)