Jörg Melzig

National Institute of Mental Health

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William L. Pak

Purdue University West Lafayette

Martin G. Burg

Grand Valley State University

Sigrid Buchner

University of Würzburg

Howard A. Nash

National Institute of Mental Health

Martin Heisenberg

University of Würzburg

Erich Buchner

University of Würzburg

Antonio Prado

University of Queensland

Thomas Raabe

University of Würzburg

Zhonghui Guan

University of California, San Francisco

Ronni Wolf

Hebrew University of Jerusalem

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University of Würzburg

National Institute of Mental Health

Purdue University West Lafayette

The University of Texas Southwestern Medical Center

University of Zurich

Max Planck Institute for Biological Cybernetics

State Street (United States)

Rockefeller University

Johns Hopkins Medicine

Johns Hopkins University

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Mushroom body defect , a gene involved in the control of neuroblast proliferation in Drosophila , encodes a coiled–coil protein

Proceedings of the National Academy of Sciences (2000)

Zhonghui Guan Antonio Prado Jörg Melzig Martin Heisenberg Howard A. Nash

Neurogenesis relies on the establishment of the proper number and precisely controlled proliferation of neuroblasts, the neuronal precursor cells. A role for the mushroom body defect ( mud ) gene in both of these aspects of neuroblast behavior, as well as possible roles in other aspects of fruit fly biology, is implied by phenotypes associated with mud mutations. We have localized mud by determining the sequence change in one point mutant, identifying a predicted ORF affected by the mutation, and showing that an appropriate segment of the genome rescues mud mutant phenotypes. An analysis of mud cDNAs and a survey of mud transcripts by Northern blotting indicate that the gene is subject to differential splicing and is expressed primarily during embryogenesis but also, at lower levels, during subsequent developmental stages in a sexually dimorphic manner. The gene is predicted to encode a polypeptide without obvious homologs but with two prominent structural features, a long coiled coil that constitutes the central core of the protein and a carboxyl-terminal transmembrane domain.

Neuroblast

Mushroom bodies

10.1073/pnas.97.14.8122

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Genetic depletion of histamine from the nervous system of Drosophila eliminates specific visual and mechanosensory behavior

Journal of Comparative Physiology A (1996)

Jörg Melzig Sigrid Buchner Franziska F. Wiebel Ronni Wolf Erich Buchner

10.1007/bf00207355

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Citations (95)