Vesna Janevska

Saints Cyril and Methodius University of Skopje

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Liljana Spasevska

Saints Cyril and Methodius University of Skopje

Gordana Petrushevska

Saints Cyril and Methodius University of Skopje

Slavica Kostadinova-Kunovska

Saints Cyril and Methodius University of Skopje

Vlado Janevski

Saints Cyril and Methodius University of Skopje

Rubens Jovanović

Saints Cyril and Methodius University of Skopje

Dafina Nikolova

Saints Cyril and Methodius University of Skopje

Blagica Dukova

Institute of public health of Republic of Macedonia

Rubens Jovanovik

Saints Cyril and Methodius University of Skopje

Milan Samardziski

PHI University Psychiatric Clinic - Skopje

V. Vasilevska

Medical University of Vienna

Cooperative Institutions

Saints Cyril and Methodius University of Skopje

132

University Clinic of Traumatology

PHI University Psychiatric Clinic - Skopje

Institute of public health of Republic of Macedonia

University Clinical Centre

Institut za Reumatologiju

University of Ss. Cyril and Methodius in Trnava

Goce Delcev University

University "St. Kliment Ohridski" - Bitola

Research Institute of Radiology

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EBV Positive Gastric Carcinomas and Their Clinicopathological Characteristics

Open Access Macedonian Journal of Medical Sciences (2018)

Ljubomir Ognjenovic Aleksandar Shumkovski Stojan Gjoshev Goce Volchevski Ѓорѓи Трајковски

BACKGROUND: The understanding of the etiopathogenesis of gastric carcinoma (GC) can be a base for development of new therapeutic methods to reduce mortality and to increase survival in patients with GC. The percentage of Epstein - Barr virus (EBV) positive gastric carcinomas is uncertain, and the etiologic importance of EBV in the pathogenesis of GC has still not been elucidated. AIM: This study aimed to determine the percentage of EBV associated GC as well as to determine their clinicopathological characteristics. MATERIAL AND METHODS: The study included 80 patients with GC who were analysed for ethnicity, local growth of a tumour (T status), the presence of nodal metastases (N), the presence of distant metastases (M), stage of the disease and degree of carcinoma differentiation. For detection of EBV, immunostainings were performed on tumour tissue and the peripheral non-tumour gastric mucosa. RESULTS: Positive immunostaining with an antibody against EBV was found in 19 (23.75%) of the 80 patients with gastric carcinomas. EBV immunostainings were significantly different in patients with or without metastasis and between patients of Macedonian and Albanian ethnicity (p < 0.0001, p < 0.009, respectively). EBV immunoexpression was significantly associated with the presence of distant metastases and with patients of Albanian ethnicity. CONCLUSION: Association of EBV immunostainings with distant metastasis in patients with GC suggests the influence of EBV infection on the progression of gastric carcinoma. Due to scarce and doubtful literature data on EBV associated GC, further studies are necessary to determine the role of EBV regarding aetiology, treatment and prognosis in patients with EBV associated gastric carcinoma.

Immunostaining

Pathogenesis

Etiology

Distant metastasis

10.3889/oamjms.2018.409

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Citations (2)

S122 Quantitative immunofluorescent detection of p53 protein in urinary bladder cancer samples

European Urology Supplements (2013)

Скендер Саиди Ž. Popov Сотир Ставридис Vesna Janevska Сашо Панов

Urinary Bladder Cancer

Cancer Detection

10.1016/s1569-9056(13)62155-7

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Osteosarcoma: diagnosis and treatment

Journal of Pediatric Neurosciences (2010)

Milan Samardziski George Zafiroski Vesna Janevska O. Muratovska S. Glamocanin

Osteosarcoma is an aggressive and malignant bone tumor most commonly appearing around the knee and shoulder in adolescents and young adults. The tumors can be generally divided into those arising inside the bone and those arising on the surface of the bone. The course of the disease and its prognosis can be different. Multidisciplinary approach in diagnosis and treatment is mandatory. Surgical resection with wide margins after neoadjuvant chemotherapy and adjuvant chemotherapy after surgery is a current standard of care. Applying modern chemotherapy regimen and performing limb-salvage surgery calls for responsible, trained and highly engaged medical staff. If the treatment and management principles of osteosarcoma are followed, limb-sparing with 60-80% survival rates can be achieved. Basic science is making continuous advance in molecular mechanisms and biologic pathways that may yield more specific agents, less-toxic drugs that will further improve overall long-term survival rates.

Regimen

Adjuvant Chemotherapy

Standard of care

10.17334/jps.22344

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Morphological Characteristics of the Stroma in Malignat Epithelial Neoplasms with Short Review of Skin Squamous Cell Carcinoma

Macedonian Medical Review (2014)

Lena Kakasheva-Mazhenkovska Vesna Janevska Gordana Petrushevska Liljana Spasevska Neli Basheska

Abstract The stroma of the neoplasm is a highly complex structure built by: specialized mesenchymal cells typical for each tissue surroundings, cancer associated fibroblast/myofibroblast, congenital or acquired immune cells, vascular network with endothelial cells and pericytes, mastocytes, macrophages, leukocytes and adipocytes, all together incorporated in the extracellular matrix. Each neoplasm produces its own unique microenvironment where the tumor grows and modifies. Although most of the cells of the host in the stroma have compulsory tumor suppressor ability, the stroma is changing during the malignant process and it even promotes growth, invasion and metastasis. Genetic changes that occur during the development of the cancer, which are guided by the malignant cells lead to changes in the stroma of the host that will overtake it and adjust it to their own needs. In the early stages of the tumor development and invasion, the basal membrane is degraded and the stroma becomes active and contains an increased number of fibroblasts, inflammatory infiltrate and newly composed capillaries which come into direct contact with the tumor cells. These changes lead to cancer invasion.

Cancer-Associated Fibroblasts

Myofibroblast

10.2478/mmr-2014-0002

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Collision of adenocarcinoma and gastrointestinal stromal tumour in the stomach: a case report

Pathology (2014)

Liljana Spasevska Vesna Janevska Blagica Dukova Elizabeta Trajkovska Vlado Janevski

CD117

10.1097/01.pat.0000454373.64575.ee

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Imaging diagnosis of musculoskeletal hydatid disease.

PubMed (2007)

V. Vasilevska G Zafirovski N. Kirjas Vesna Janevska Milan Samardziski

Hydatid disease has a worldwide distribution and causes health problems in endemic countries. Musculoskeletal hydatid disease may be a difficult differential diagnosis. The aim of this retrospective study is to present some different imaging features of musculoskeletal hydatid disease. We evaluated imaging findings of 15 patients with musculoskeletal hydatid disease over a 15-year period. Ten (67%) were men and 5 (33%) women, ages ranging between 12 and 69 years. All underwent radiographic evaluation. CT was done in 9 patients and MRI in 3 patients with soft tissue involvement. All underwent surgery, followed by histological examination. Bone involvement occurred in 11 patients and soft-tissue involvement in 4 patients respectively. Bone lesions in the spine were found in 4 (36%), in the pelvis 2 (18%), in the proximal femur 2 (18%), in the tibia 2 (18%) and 1 (9%) in the first metatarsal. On plain film we identified three different patterns of presentation of bone HD, defined as "typical" osteolytic lesion (33%), "tumour-like" features (41.6%) and lesions resembling infection (25%). Soft-tissue hydatidosis was localized on the distal part of the thigh, paravertebral and deltoid muscle. MR imaging showed a cystic mass, containing multiple vesicles, and in one of them the pathognomonic for hydatid disease, the "water lily" sign, was present. We present three cases of primary musculoskeletal hydatid disease localized on metatarsal bone, proximal femur and deltoid muscle. Musculoskeletal hydatid disease, presenting with a variety of patterns, may resemble a tumour or an inflammatory process. Because of the rare presentation of the disease it should be kept in mind in the diagnostic work-up of musculoskeletal tumours.

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Reactive Stroma in Prostatic Carcinoma and Correlation with Tumor Grade and Tumor Stage

Macedonian Medical Review (2017)

Vanja Filipovski Katerina Kubelka‐Sabit Dzengis Jasar Gligor Dimitrov Vesna Janevska

Abstract Introduction. Reactive stroma co-evolves with prostatic carcinoma. The aim of this study is to establish stromal changes in the prostatic cancer tissue and to quantify those changes. Methods. Samples from 70 patients treated with radical prostatectomy due to prostatic cancer were used for this analysis. Stromal changes in prostatic cancer tissue were analyzed using histochemical stain Trichrome Masson and immunohistochemical stains Vimentin and Desmin and those changes were compared to the stromal composition in the surrounding benign prostatic hyperplasia. These changes were quantified as following: for the histochemical stain Trichrome Masson we measured the intensity of the stain and for the immunohistochemical stains Vimentin and Desmin we used the “stromal index” that combines the frequency and intensity of the signal. We correlated the received data between each parameters and with tumor grade and tumor stage using the Spearman rank correlation test. Results. There was significant correlation between Trichrome Masson staining intensity and tumor grade (R=0,27 p=0,023) and tumor stage (R=0,24 p=0,049), between Vimentin expression and tumor grade (R=0,35 p=0,003) and tumor stage (R=0,28 p=0,019) and between Desmin expression and tumor grade (R=−0,25 p=0,035). Conclusion. Analyses of the stromal composition and the expression of stromal markers in prostatic carcinoma and their quantification could serve as an additional tool in evaluation of tumor aggressiveness and tumor extension.

Masson's trichrome stain

Trichrome stain

Desmin

10.1515/mmr-2017-0021

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Late Onset of Pancreatic Metastases from Renal Cell Carcinoma. A Case Report

PRILOZI (2020)

Vesna Janevska Aleksandar Shumkovski Dafina Nikolova Learta Veliu Asani Stefan Pandilov

Abstract Metastasis of renal cell carcinoma (RCC) to the pancreas is a rare entity accounting only 0.25–3% of all pancreatic tumors. We present a rare case of isolated three focal pancreatic metastases from RCC, occurring 15 years after the left nephrectomy. The majority of the pancreatic metastases are asymptomatic, as it was in case of our patient excluding the weight loss for the last three months. We demonstrate the importance of the medical history, radiological examinations, histological and immunohistochemical analysis in making a definitive diagnosis.

Pancreatic carcinoma

10.2478/prilozi-2020-0033

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Citations (3)

Compared With Radical Nephrectomy, Nephron-sparing Partial Nephrectomy Protects Apolipoprotein E–deficient Mice From Atherosclerosis Progression

Urology (2015)

Ognen Ivanovski Igor Nikolov O. Davceva Kalina Gjorgjievska Vesna Janevska

10.1016/j.urology.2015.02.004

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Incidence of urinary tract tumours in a two-year period (2010-2011) at the Institute of Pathology, Faculty of Medicine, Skopje, Macedonia.

PubMed (2014)

Slavica Kostadinova-Kunovska Vesna Janevska Selim Komina Blagica Dukova Magdalena Bogdanovska Todorovska

We performed a retrospective analysis of tumours of the kidneys and the lower urinary tract diagnosed at the Institute of Pathology, Faculty of Medicine, Ss. Cyril and Methodius University, Skopje, Macedonia, in a two-year period (2010-2011), with the aim of highlighting the main morphological characteristics and to present the statistical features of these tumours. All the cases were diagnosed on paraffin sections from surgical specimens routinely stained with H&E, and immunohistochemically with a panel of monoclonal antibodies. The analysis revealed a total of 755 cases, of which 166 (14%) were located in the kidney including the renal pelvis, and 649 (86%) were tumours of the urinary bladder. Twelve of the renal tumours (11.3%) were benign, and the rest were malignant tumours. Most of them were adenocarcinomas (n=77; 72.6%) and 17 cases (16%) were transitional cell carcinomas originating from the renal pelvis. The analysis of the lower urinary tract tumours showed a strong prevalence of malignant urothelial tumours (96%), with a male to female ratio of almost 4:1. Low grade morphology was a predominant feature (71.7%) and 51 cases (22.9%) were of high grade. The percentage of urothelial tumours of the kidney in our series is higher than in most of the reported series, which should lead to an expanded analysis.

Renal pelvis

Surgical pathology

Renal pathology

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