Jingwei Zheng

Wenzhou Medical University

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Xian Shen

Wenzhou Medical University

Yuanbo Liang

Wenzhou Medical University

Fan Lü

Wenzhou Medical University

Zhaolong Ge

Chongqing University

Zongduan Zhang

Wenzhou Medical University

Xuting Hu

Affiliated Eye Hospital of Wenzhou Medical College

Xiaohong Chen

Sun Yat-sen University

Zhe Zhou

Chongqing University

Xinping Yu

Sun Yat-sen University

Qintuo Pan

Affiliated Eye Hospital of Wenzhou Medical College

Cooperative Institutions

Wenzhou Medical University

316

Affiliated Eye Hospital of Wenzhou Medical College

196

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

National Clinical Research Center for Digestive Diseases

Chinese Academy of Sciences

Sun Yat-sen University

Zhejiang University

Shanghai Jiao Tong University

First Affiliated Hospital of Wenzhou Medical University

Chongqing University

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[An investigation on chromosome aberration of SO-Rb50 cloned cell strains].

PubMed (1998)

Li Huang Guanguang Feng Yan Fang Y Li Jingwei Zheng

To compare the differences of chromosome aberration among 3 cloning cells (MC2, MC3 and MC4) of SO-Rb50 cell line.G-banding and karyotype analysis were performed on the 11th passage cells of MC2, MC3 and MC4 cell strains.Both numerical abnormal and structural aberrations of chromosomes could be observed in these 3 cloned cell strains. Diploid cells had the preponderance over the aneuploid cells. However, some cells showed pseudiploid karyotypes. Several kinds of structural chromosome aberrations were observed. The chromosome aberrations in the same passage of different cell strains were different. Aberration of chromosome 13 was rare and the aberration feature were different in 3 cloned cell strains. Five marker chromosomes were identified. M1, t(1;1) qterp35::q24-ter could be found in all cell strains. Other markers were seen in different cell strains respectively. In our experiment, two marker chromosome in chromosome 2, M4 and M5, were found in SO-Rb50 cell line for the first time.Chromosome aberrations were different with different cloned cell strains. Combined with formerly study in SO-Rb50 cell line, we found the chromosome aberration had dynamic changes during the long-term culture in vitro. We suggest that aberration of chromosome 13 is not the only cause of Rb; aberration of chromosome 1, a common event in some neoplasias as well as in SO-Rb50, plays a meaningful role in the immortalization of this cell line; other aberrations observed in our experiment could be considered as evidences of genomic instability of the cell strains and presumably enhance the growth potential of the cells in which they develop.

Chromosome aberration

Cloning (programming)

Marker chromosome

Chromosome instability

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Repeatability and agreement of AOCT-1000 M, RTVue XR and IOL master 500 in measuring corneal thickness mapping and axial length applying principle of optical coherence tomography

BMC Medical Imaging (2023)

Hailong Ni Suzhong Xu Tian Li Jieli Mao Jing Li

Abstract Purpose To evaluate the repeatability and agreement of Fourier-domain optical coherence tomography (AOCT-1000 M and RTVue XR) and partial coherence interferometry biometer (IOL Master 500) in measuring corneal thickness mapping and axial length respectively. Methods Corneal thickness was measured by AOCT-1000 M and RTVue XR. Axial lengths were measured by AOCT-1000 M and IOL Master 500. The repeatability and agreement of corneal thickness and axial length were calculated in two groups of devices. The intraclass correlation coefficient (ICC) was used to verify the repeatability of the device. The 95% confidence interval of the difference compared to the set cut-off value was used to verify the agreement between the two devices. Results A total of 60 subjects with 58 eyes were included. The central corneal thickness measured by AOCT-1000 M and RTVue XR were 504.46 ± 42.53 μm and 504.43 ± 42.89 μm respectively. The average difference between groups was 0.03 ± 4.58 μm, and the 95% confidence interval was (-1.17, 1.24), which was far less than the set threshold value of 15 μm (P < 0.001). Both RTVue XR and AOCT-1000 M had very good ICC values of central corneal thickness (0.998 and 0.994, respectively). The average axial lengths measured by AOCT-1000 M and IOL Master 500 were 24.28 ± 1.25 mm and 24.29 ± 1.26 mm respectively and the 95% confidence interval was (-0.02, 0.01), which was less than the set threshold value of 0.15 mm (P < 0.001). The ICC for both devices were 1.000. Conclusion Good repeatability and agreement were seen in measurements of central corneal thickness and axial length by AOCT-1000 M.

Repeatability

10.1186/s12880-023-01147-7

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Citations (3)

Epicardial adipose tissue volume is associated with non-alcoholic fatty liver disease and cardiovascular risk factors in the general population

DOAJ (DOAJ: Directory of Open Access Journals) (2018)

X Meng Weihua Wang K Zhang Yujin Qi Shuai An

Epicardial adipose tissue

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Fracture initiation pressure and failure modes of tree-type hydraulic fracturing in gas-bearing coal seams

Journal of Natural Gas Science and Engineering (2020)

Shaojie Zuo Zhaolong Ge Kai Deng Jingwei Zheng Wang Hao-min

10.1016/j.jngse.2020.103260

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Citations (35)

Silicone Tube Miniature Drainage Device Implanted under Scleral Flap for the Surgical Treatment of Glaucoma

Current Eye Research (2020)

Aiwu Fang Li Nie Peijuan Wang Jingwei Zheng Yau Kei Chan

Purpose To evaluate the safety and efficacy of a silicone tube miniature drainage device implanted under scleral flap for the surgical treatment of primary open-angle glaucoma (POAG).Methods This is a non-randomized prospective study. Patients with a minimum follow-up of 12 months were analyzed. Demographic information, preoperative and postoperative data including intraocular pressure (IOP), number of medications and complications were recorded.Results A total of 33 eyes of 33 patients were included in the analysis. Mean postoperative follow-up was 29.5 ± 6.9 months (range 18–50 months). The mean preoperative IOP was 25.8 ± 7.3 mmHg and decreased to 14.9 ± 4.3, 14.2 ± 3.4 and 14.9 ± 3.3 mmHg at 1 year, 2 years and last follow-up after surgery. The number of medications was decreased from 3.1 ± 1.3 preoperatively to 0.2 ± 0.7, 0.4 ± 0.9 and 0.4 ± 1.0 at 1 year, 2 years and last follow-up, respectively, after surgery. Only six (18.2%) patients used glaucoma medications at last visit. The complete success rates were 87.9% and 78.6%, respectively, at 1 and 2 years postoperatively. The operation-related complications were rare.Conclusions The silicone tube miniature drainage device implanted under the scleral flap was found to be a relatively safe and effective surgery for the treatment of POAG. Longer follow-up periods and larger sample sizes are expected.

10.1080/02713683.2019.1701687

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Evaluation of the Chinese Adult Strabismus-20 (CAS-20) questionnaire using Rasch analysis

Chinese Journal of Optometry & Ophthalmology (2015)

Meiping Xu Jingwei Zheng Xinping Yu Yuanyuan Chen

Objective To further refine the Chinese Adult Strabismus-20 (CAS-20) healthrelated quality of life (HRQOL) questionnaire using Rasch analysis. Methods In this crosssectional study, the CAS- 20 questionnaire was independently completed by 246 adult strabismus patients. Based on the score for each item, Rasch analysis was performed on the original CAS-20 using the following aspects: dimensionality, response order, local dependence, infit and outfit analysis, differential item function, subject targeting and confirmatory dimensionality. Results The original CAS-20 was divided into 4 subscales, which were labeled ″self-perception″, ″interaction″, ″reading function″, and ″general function″. Response ordering was appropriate for all of the 4 subscales. As a result of infit and outfit analysis, 3 items were removed, one each from selfperception″, ″reading function″, and ″general function″. No significant differential item function was found for sex or age. Compared with the ability of the patients and item difficulty, the 3 subscales matched well except for ″reading function″. Conclusion The original CAS-20 was reduced to 17 items, and divided into 4 subscales, which were ″self-perception″, ″interaction″, ″reading function″, and ″general function″. Subject response choices saved 5 test options. The refined CAS- 20 may prove to be more responsive to HRQOL changes in adult strabismus patients. Key words: Rasch analysis; Adult strabismus health related quality of life questionnaire; Subscale; Strabismus

Differential item functioning

Polytomous Rasch model

10.3760/cma.j.issn.1674-845x.2015.04.008

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Clinical Significance of Perioperative Hyperglycemia in Radical Gastrectomy Among Non- diabetic Patients: Evidence for Better Perioperative Glucose Management in Different Anastomotic Methods

Research Square (Research Square) (2023)

Zhiqiang Yu Dianfeng Mei Chenchen Mao Zhixuan Jiang Jiancan Shao

Abstract Background: Uncontrolled perioperative hyperglycemia (HG) in patients undergoing surgery was determined as a risk factor for postoperative complications. Few studies have focused on the effects of HG in gastric cancer patients undergoing different anastomotic methods after radical gastrectomy. Methods: We performed a double-institutional dataset study involving 811 patients who had undergone radical gastrectomy between 2014 and 2017. Patients with diabetes mellitus were excluded. Propensity-score-matching (PSM) analysis was performed to strictly balance the significant variables. The association between any elevated perioperative glucose value (HG≥7 mmol/L) and postoperative complications in patients treated with different anastomotic methods was assessed. Results: Among the 742 non-diabetic patients with gastric cancer, 100 (13.48%) and 148 (19.95%) experienced preoperative and postoperative HG, respectively. Perioperative HG was not significantly associated with postoperative complications. On comparing the different anastomotic methods, differences in postoperative complication incidence were exclusively identified between postoperative hypoglycemia and HG (20.32% vs. 34.62%, P=0.025) among patients underwent Billroth-I anastomosis. Further logistic regressive analysis found HG to be independently associated with postoperative complications before (odds ratio [OR]:1.989, 95% confidence interval [CI]:1.031–3.837, P=0.040) and after (OR:3.341, 95%CI: 1.153–9.685, P=0.026) PSM. Finally, preoperative HG remained a significant predictor of postoperative HG (OR:3.718, 95%CI: 1.673–8.260, P=0.001). Conclusions: Postoperative HG, rather than preoperative HG, was significantly associated with worse postoperative outcomes in non-diabetic patients who underwent Billroth-I anastomosis after radical gastrectomy. However, preoperative HG was associated with postoperative HG, suggesting that improved preoperative glycemic management may help reduce postoperative hyperglycemic events.

Billroth I

10.21203/rs.3.rs-3306146/v1

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Substance P Induces Sympathetic Immune Response in the Contralateral Eye after the First Eye Cataract Surgery in Type 2 Diabetic Patients

Research Square (Research Square) (2020)

Xianhui Gong Yueping Ren Wenjie Pan Jingwei Zheng Xiuxiu Fang

Abstract Background: Substance P (SP) is a nociceptive tachykinin which regulates the immune inflammatory reactions including monocyte chemoattractant protein 1 (MCP-1) production. Sequential second-eye cataract surgery patients often suffer more pain than the first one partly because of the MCP-1 increase in aqueous humor (AH). This study aims to illustrate whether SP is involved in sympathetic inflammatory responses in the contralateral eye in patients with or without type 2 diabetes. Methods: This prospective randomized clinical study included 51 cataract patients (22 with diabetes and 29 without). Bilateral sequential cataract surgeries were conducted with 1-day or 1-week interval randomly. More than 100 µl of AH were obtained before surgery and stored for later analysis using magnetic Luminex assays to detect interleukin (IL)-1β, IL-1ra,IL-6, IL-8, IL-10, MCP-1, vascular endothelial growth factor, spinal macrophage inflammatory protein (MIP-1a), interferon-inducible protein 10 (IP-10), regulated on activation, normal T expressed and secreted (RANTES), as well as the enzyme-linked immunosorbent assay for SP. Results: Among the 4 groups, no significant differences were found in age, sex distribution, the R/L ration of the first surgery eye, or the lens nucleus hardness (P ≥ 0.802). Over 100 µl of AH samples were collected safely in all cases without intraoperative complications. SP and MCP-1 levels were both increased significantly in the second eye of the diabetic patients with 1-day and 1-week interval ( P ≤ 0.040). The SP increase in the second eye of the diabetic patients were significantly higher than that of the patients without diabetes ( P ≤ 0.030) both in the groups with 1-day and 1-week interval. Similarly, the MCP-1 increase was significantly higher in the diabetic patients in the group with 1-week interval (P = 0.042). Conclusions: Substance P and MCP-1 productions elevated in the AH of the contralateral eye after the first-eye cataract surgery in diabetic patients, indicating that SP and MCP-1 were involved in the sympathetic inflammatory responses. Diabetic patients are susceptible to noninfectious inflammation after cataract surgery, and perceive more pain in the second-eye phacoemulsification. Trial registration: Chinese Clinical Trial Registry, ChiCTR1900028374, retrospectively registered on 20th December, 2019.

Monocyte

10.21203/rs.2.20428/v3

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Investigation of Asthenopia and Related Factors in the General Public in China

Chinese Journal of Optometry & Ophthalmology (2019)

Ruzhi Deng Yu Zhu Jiafan Zhang Na Lin Xiao-Man Li

Objective: To investigate the incidence of asthenopia in the general public in China and the factors that influence it. Methods: This was a cross-sectional investigation. A questionnaire was distributed to the general public in China from June 2016 to January 2017 by paper and the internet. The questionnaire included three main dimensions: Eye discomfort, visual symptoms and systemic symptoms. Results: A total of 1 909 valid questionnaires were collected from 163 cities in 24 provinces and were included in this cross-sectional investigation study. The incidence of ocular complaints and dry eye was 13.28% and 16.26%, which were the most common symptoms in the eye discomfort dimension. The incidence of ocular complaints and dry eye was significantly higher in people over 40 years of age than in people below 40 years of age (χ2=13.359, P<0.001; χ2=9.870, P=0.002). Among people who had dry eye, there was a 44.85% incidence of ocular complaints and there was a 54.66% incidence of dry eye among people who had ocular complaints. There was a significant correlation between dry eye and ocular complaints (r=0.407, P=0.01). The incidence of blur and blur that cleared after blinking was 11.51% and 11.95%, respectively, which were the most common symptoms in the visual symptom dimension. The incidence of hard to focus and forgetful, and slower reading speed were 13.05% and 13.13%, respectively, which were the most common symptoms in the systemic symptom dimension. Age was significantly related to these symptoms (OR=1.02, P=0.008; OR=1.02, P<0.001). Conclusions: The incidence of different asthenopia symptoms in the general public in China is high, including eye discomfort, visual symptoms and systemic symptoms. Age and amount of time working at near distance are important factors for eye discomfort. Age is the important factor for the visual and systemic symptoms of asthenopia. Key words: asthenopia; eye discomfort; visual symptom; systemic symptom

Cross-sectional study

Clearance

10.3760/cma.j.issn.1674-845x.2019.09.005

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Citations (4)

Phacoemulsification Complication

Ophthalmology (2010)

Wensheng Li Yun‐e Zhao Qinxiang Zheng Ronghan Wu Jingwei Zheng

10.1016/j.ophtha.2009.12.028

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Citations (4)