Ramiro Macenlle

Complejo Hospitalario de Ourense

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Joaquín Cubiella

Complejo Hospitalario de Ourense

Vicent Hernández

University Hospital Complex Of Vigo

Lucía Cid

Galicia Sur Biomedical Foundation

Pamela Estévez

University Hospital Complex Of Vigo

Pablo Vega

Complejo Hospitalario de Ourense

Luís Bujanda

Biogipuzkoa Health Research Institute

Felipe Iglesias

University Hospital Complex Of Vigo

Inés Castro

The Ohio State University

Estela Cid

Complejo Hospitalario de Ourense

Concepción Rivera

Complejo Hospitalario de Ourense

Cooperative Institutions

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

154

Instituto de Salud Carlos III

Universitat de Barcelona

Centro de Investigación Biomédica en Red

Complexo Hospitalario Universitario A Coruña

Universitat Autònoma de Barcelona

Hospital Clínic de Barcelona

Consorci Institut D'Investigacions Biomediques August Pi I Sunyer

University Hospital Complex Of Vigo

Vall d'Hebron Hospital Universitari

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Characteristics of Adenomas Detected by Fecal Immunochemical Test in Colorectal Cancer Screening

Cancer Epidemiology Biomarkers & Prevention (2014)

Joaquín Cubiella Inés Castro Vicent Hernández Carmen González‐Mao Concepción Rivera

Fecal immunochemical test (FIT) diagnostic accuracy for colorectal adenoma detection in colorectal cancer screening is limited.We analyzed 474 asymptomatic subjects with adenomas detected on colonoscopy in two blinded diagnostic tests studies designed to assess FIT diagnostic accuracy. We determined the characteristics of adenomas (number, size, histology, morphology, and location) and the risk of metachronous lesions (according to European guidelines). Finally, we performed a logistic regression to identify those variables independently associated with a positive result.Advanced adenomas were found in 145 patients (75.6% distal and 24.3% only proximal to splenic flexure). Patients were classified as low (59.5%), intermediate (30.2%), and high risk (10.3%) according to European guidelines. At a 100-ng/mL threshold, FIT was positive in 61 patients (12.8%). Patients with advanced adenomas [odds ratio (OR), 8.8; 95% confidence interval (CI), 4.76-16.25], distal advanced adenomas (OR, 6.7; 95% CI, 1.9-8.8), high risk (OR, 20.1; 95% CI, 8.8-45.8), or intermediate risk lesions (OR, 6; 95% CI, 2.9-12.4) had more probabilities to have a positive test. The characteristics of adenomas independently associated were number of adenomas (OR, 1.22; 95% CI, 1.04-1.42), distal flat adenomas (OR, 0.44; 95% CI, 0.21-0.96), pedunculated adenomas (OR, 2.28; 95% CI, 1.48-3.5), and maximum size of distal adenomas (mm; OR, 1.24; 95% CI, 1.16-1.32).European guidelines classification and adenoma location correlates with the likelihood of a positive FIT result.This information allows us to understand the FIT impact in colorectal cancer prevention. Likewise, it should be taken into account in the development of new colorectal adenomas biomarkers.

10.1158/1055-9965.epi-13-1346

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Citations (17)

Ganglioneuromatous polyposis of the colon associated with adenocarcinoma and primary hyperparathyroidism

European Journal of Gastroenterology & Hepatology (1999)

Ramiro Macenlle Javier Fernández‐Seara M. Pato Juan Pereira Pedro Pascual

A rare case of ganglioneuromatous polyposis of the colon found in association with mucinous adenocarcinoma and primary hyperparathyroidism caused by a parathyroid adenoma in a 77-year-old woman is described. We discuss the clinical implications of this finding and review the literature. Eur J Gastroenterol Hepatol 11:447–450 1999 Lippincott Williams & Wilkins

Colorectal adenoma

10.1097/00042737-199904000-00015

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Citations (20)

Role of Artificial Intelligence in Colonoscopy Detection of Advanced Neoplasias

Annals of Internal Medicine (2023)

Carolina Mangas‐Sanjuán Luisa de–Castro Joaquín Cubiella Pilar Díez‐Redondo Adolfo Suárez

The role of computer-aided detection in identifying advanced colorectal neoplasia is unknown.To evaluate the contribution of computer-aided detection to colonoscopic detection of advanced colorectal neoplasias as well as adenomas, serrated polyps, and nonpolypoid and right-sided lesions.Multicenter, parallel, randomized controlled trial. (ClinicalTrials.gov: NCT04673136).Spanish colorectal cancer screening program.3213 persons with a positive fecal immunochemical test.Enrollees were randomly assigned to colonoscopy with or without computer-aided detection.Advanced colorectal neoplasia was defined as advanced adenoma and/or advanced serrated polyp.The 2 comparison groups showed no significant difference in advanced colorectal neoplasia detection rate (34.8% with intervention vs. 34.6% for controls; adjusted risk ratio [aRR], 1.01 [95% CI, 0.92 to 1.10]) or the mean number of advanced colorectal neoplasias detected per colonoscopy (0.54 [SD, 0.95] with intervention vs. 0.52 [SD, 0.95] for controls; adjusted rate ratio, 1.04 [99.9% CI, 0.88 to 1.22]). Adenoma detection rate also did not differ (64.2% with intervention vs. 62.0% for controls; aRR, 1.06 [99.9% CI, 0.91 to 1.23]). Computer-aided detection increased the mean number of nonpolypoid lesions (0.56 [SD, 1.25] vs. 0.47 [SD, 1.18] for controls; adjusted rate ratio, 1.19 [99.9% CI, 1.01 to 1.41]), proximal adenomas (0.94 [SD, 1.62] vs. 0.81 [SD, 1.52] for controls; adjusted rate ratio, 1.17 [99.9% CI, 1.03 to 1.33]), and lesions of 5 mm or smaller (polyps in general and adenomas and serrated lesions in particular) detected per colonoscopy.The high adenoma detection rate in the control group may limit the generalizability of the findings to endoscopists with low detection rates.Computer-aided detection did not improve colonoscopic identification of advanced colorectal neoplasias.Medtronic.

10.7326/m22-2619

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Citations (32)

Resistance‐associated substitutions after sofosbuvir/velpatasvir/voxilaprevir triple therapy failure

Journal of Viral Hepatitis (2021)

Damir García‐Cehic Ariadna Rando‐Segura Francisco Rodríguez‐Frias Josep Gregori Juan García Costa

Direct-acting antivirals (DAAs) resolve chronic HCV infection in >95% of patients, but a small percentage do not respond to DAA-based therapy. These may be difficult to treat because of resistance-associated substitutions (RAS) emerging after treatment failure. Triple therapy with sofosbuvir (SOF)/velpatasvir (VEL)/voxilaprevir (VOX) is the recommended retreatment after DAA-based failure. However, in rare cases, failure to triple therapy occurs, and there is little information characterizing the viruses that relapse. To determine the RAS profile after failing SOF/VEL/VOX, and seek suitable alternatives for retreatment, samples from 5 patients were analysed using MiSeq Illumina deep sequencing before and after triple therapy. All patients were men, aged 59-78 years, 2 HCV genotype (G) 1b and 3 G3a. The most prevalent NS3 substitutions after SOF/VEL/VOX failure were Y56F and A166T. Four patients had the NS5A RAS, Y93H, after triple failure, and Y93H was observed in both G1b patients before retreatment and after SOF/ledipasvir failure. In 2 G3a patients, Y93H appeared at triple failure, and on the other G3a, A30K persisted in 100% of viral genomes. Finally, G1b patients showed C316N in NS5B, associated with SOF failure, but G3a patients had no known NS5B substitutions. HCV RAS analysis identified the following substitutions present at higher rates after triple failure: Y56F in NS3 (G1b), A166T in NS3 (G3a), A30K or Y93H in NS5A, and C316N in NS5B (G1b). A RAS-based salvage treatment (SOF + glecaprevir/pibrentasvir + RBV) was successfully used in one G3a patient.

Sofosbuvir

NS5A

NS5B

10.1111/jvh.13497

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Citations (12)

Accuracy of the Narrow-Band Imaging International Colorectal Endoscopic Classification System in Identification of Deep Invasion in Colorectal Polyps

Gastroenterology (2018)

Ignasi Puig María López‐Cerón Anna Arnau Òria Rosiñol Míriam Cuatrecasas

Nice

Narrow-band imaging

Submucosa

10.1053/j.gastro.2018.10.004

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Citations (99)

Diagnostic accuracy of fecal immunochemical test in average‐ and familial‐risk colorectal cancer screening

United European Gastroenterology Journal (2014)

Joaquín Cubiella Inés Castro Vicent Hernández Carmen González‐Mao Concepción Rivera

There is little information about the fecal immunochemical test (FIT) in familial-risk colorectal cancer (CRC) screening.The objective of this article is to investigate whether FIT diagnostic accuracy for advanced neoplasia (AN) differs between average and familial-risk (first-degree relative) patients.A total of 1317 consecutive participants (595 familial) who collected one stool sample before performing a colonoscopy as a CRC screening test were included. FIT diagnostic accuracy for AN was evaluated with Chi-square test at a 20 µg hemoglobin/g of feces cut-off value. Finally, we determined which variables were independently related to AN.An AN was found in 151 (11.5%) patients. The overall accuracy was not statistically different between both cohorts for AN (88.4%, 91.7%; p = 0.051). At the cut-off stablished, differences in FIT sensitivity (31.1%, 40.6%; p = 0.2) or specificity (96.5%, 97.3%; p = 0.1) were not statistically significant. Finally, independent variables such as sex (male) (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.4-3.1), age (50-65, >65 years) (OR 2.1, 95% CI 1.1-4.3; OR 2.7, 95% CI 1.2-6.1), previous colonoscopy (OR 0.4, 95% CI 0.2-0.9) and FIT ≥20 µg/g feces (OR 17.7, 95% CI 10.8-29.1) were associated with AN diagnosis.FIT accuracy for AN detection is equivalent in average and familial-risk CRC screening cohorts.

Colorectal cancer screening

10.1177/2050640614553285

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Citations (21)

Impact of age- and gender-specific cut-off values for the fecal immunochemical test for hemoglobin in colorectal cancer screening

Digestive and Liver Disease (2016)

Cristina Álvarez–Urturi Montserrat Andreu Cristina Rodríguez de Miguel Francisco Pérez‐Riquelme Fernando Carballo

Colorectal cancer screening

10.1016/j.dld.2016.02.001

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Citations (27)

Deep-sequencing reveals broad subtype-specific HCV resistance mutations associated with treatment failure

Antiviral Research (2019)

Qian Chen Celia Perales María Eugenia Soria Damir García‐Cehic Josep Gregori

NS5A

NS5B

Sofosbuvir

Hepatitis C

Pegylated interferon

10.1016/j.antiviral.2019.104694

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Citations (43)

Usefulness of Oral Video Push Enteroscopy in Crohn's Disease

Endoscopy (1997)

Enrique Pérez-Cuadrado Ramiro Macenlle J. Nieto Iglesias Ricardo Fabra Daniela Lamas

Oral endoscopic examination of the small bowel is of vital importance when studying various clinical conditions. In this study we evaluate the diagnostic yield of push-type enteroscopy in patients with undiagnosed suspected clinical Crohn's disease using lower and upper endoscopy and double contrast X-ray in order to establish the diagnostic value of this instrument in the jejunum.Eight patients displaying symptoms of Crohn's disease, five adults with chronic diarrhea and abdominal pain and three children with retarded growth and weight loss associated with diarrhea underwent ambulatory enteroscopy using a Pentax videoenteroscope.The average depth of insertion beyond the ligament of Treitz was 125 cm. Four patients (50%) were found to have macroscopic and/or microscopic lesions of Crohn's disease in the small intestine, which went unrecognized by other standard endoscopic and radiologic methods. Tolerance was good and there were no complications related to the procedure.Oral videoenteroscopy with biopsy is a safe and useful procedure for diagnosis of Crohn's disease in selected patients with suggestive symptoms and can be of great diagnostic value after failure of conventional endoscopic X-ray methods.

Enteroscopy

10.1055/s-2007-1004300

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Citations (38)

Artificial Intelligence Techniques for Colorectal Cancer Drug Metabolism: Ontologies and Complex Networks

Current Drug Metabolism (2010)

Marcos Martínez-Romero José M. Vázquez-Naya Juan R. Rabuñal Salvador Pita‐Fernández Ramiro Macenlle

Colorectal cancer is one of the most frequent types of cancer in the world and generates important social impact. The understanding of the specific metabolism of this disease and the transformations of the specific drugs will allow finding effective prevention, diagnosis and treatment of the colorectal cancer. All the terms that describe the drug metabolism contribute to the construction of ontology in order to help scientists to link the correlated information and to find the most useful data about this topic. The molecular components involved in this metabolism are included in complex network such as metabolic pathways in order to describe all the molecular interactions in the colorectal cancer. The graphical method of processing biological information such as graphs and complex networks leads to the numerical characterization of the colorectal cancer drug metabolic network by using invariant values named topological indices. Thus, this method can help scientists to study the most important elements in the metabolic pathways and the dynamics of the networks during mutations, denaturation or evolution for any type of disease. This review presents the last studies regarding ontology and complex networks of the colorectal cancer drug metabolism and a basic topology characterization of the drug metabolic process subontology from the Gene Ontology. Keywords: Ontology, graphs, colorectal cancer, complex network, drug metabolic pathway

10.2174/138920010791514289

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Citations (43)