Rabia Mumtaz

Government College University, Faisalabad

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Muhammad Zubaır

Universiti Teknologi Petronas

Muhammad Asaf Khan

Muhammad Nawaz Shareef University of Agriculture

Muhammad Azeem

Government College University, Faisalabad

Saima Muzammil

Government College University, Faisalabad

Muhammad Hussnain Siddique

Government College University, Faisalabad

Madiha Younas

Government College University, Faisalabad

Muhammad Naeem Shahid

DHA Suffa University

Errum Zubair

Government College University, Faisalabad

Shafaqat Ali

China Medical University

Sumreen Hayat

Government College University, Faisalabad

Cooperative Institutions

Government College University, Faisalabad

University of Sargodha

University of the Punjab

University of Agriculture Faisalabad

DHA Suffa University

Islamia University of Bahawalpur

Bahauddin Zakariya University

Muhammad Nawaz Shareef University of Agriculture

National University of Sciences and Technology

The University of Agriculture, Peshawar

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Polyphenolic Composition, Antioxidant, Antiproliferative and Antidiabetic Activities of Coronopus didymus Leaf Extracts

Molecules (2022)

Saima Muzammil Yunsheng Wang Muhammad Hussnain Siddique Errum Zubair Sumreen Hayat

Coronopus didymus (Brassicaceae) commonly known as lesser swine cress has been reported to be used for its pharmacological activities. This study aimed to evaluate the medicinal potential of C. didymus extracts against cancer, diabetes, infectious bacteria and oxidative stress and the identification of bioactive compounds present in these extracts. The effects of using different solvents for the extraction of C. didymus on the contents of major polyphenols and biological activities were investigated. Plant sample was shade dried, ground to a fine powder, and then soaked in pure acetone, ethanol and methanol. The highest contents of major polyphenols were found in methanol-based extract, i.e., chlorogenic acid, HB acid, kaempferol, ferulic acid, quercetin and benzoic acid with 305.02, 12.42, 11.5, 23.33, 975.7 and 428 mg/g of dry weight, respectively, followed by ethanol- and acetone-based extracts. The methanol-based extract also resulted in the highest antioxidant activities (56.76%), whereas the highest antiproliferative (76.36) and alpha glucosidase inhabitation (96.65) were demonstrated in ethanol-based extracts. No antibacterial property of C. didymus was observed against all the tested strains of bacteria. Further studies should be focused on the identification of specific bioactive compounds responsible for pharmacological activities.

Chlorogenic Acid

10.3390/molecules27196263

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Citations (20)

Impact of Personality Characteristics on Financial Inclusion of Women Employees in Pakistan: Moderating Impact of Digital Financial Literacy

NUML International Journal of Business & Management (2024)

Subeika Rizvi Azam Khan Rabia Mumtaz

The participation and inclusion of women are vital for the growth and progress of any economy. Literacy in finance is crucial for financial inclusion and facilitates, the usage of formal services in finance and products that enhance the economic opportunities for women. The aim of the study is to examine the effects of personality characteristics on financial inclusion among 250 female employees in the major metropolitan cities of Pakistan. Quantitative approach is employed in the study through a survey questionnaire to gather the data. The sampling technique was purposive which was used to select the women employees, and the PLS-SEM technique was used to analyze the data. The empirical findings of the current study show that financial attitude, behavior, and influence positively impact financial inclusion, which is moderated by digital financial literacy. This study adds value to the existing literature on the factors that affect financial literacy, especially in the context of women in Pakistan, and has important implications for policymakers in the financial sector. The paper proposes measures to enhance women’s engagement and inclusion in the financial sector and also provides future directions for research.

Financial Literacy

10.52015/nijbm.v19i2.212

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Citations (0)

Structural and Phylogenetic Analysis of CXCR4 Protein Reveals New Insights into Its Role in Emerging and Re-Emerging Diseases in Mammals

Vaccines (2023)

Fouzia Naheed Rabia Mumtaz Sana Shabbir Arshad Jamil Akhtar Rasool Asif

Chemokine receptor type 4 (CXCR4) is a G protein-coupled receptor that plays an essential role in immune system function and disease processes. Our study aims to conduct a comparative structural and phylogenetic analysis of the CXCR4 protein to gain insights into its role in emerging and re-emerging diseases that impact the health of mammals. In this study, we analyzed the evolution of CXCR4 genes across a wide range of mammalian species. The phylogenetic study showed species-specific evolutionary patterns. Our analysis revealed novel insights into the evolutionary history of CXCR4, including genetic changes that may have led to functional differences in the protein. This study revealed that the structural homologous human proteins and mammalian CXCR4 shared many characteristics. We also examined the three-dimensional structure of CXCR4 and its interactions with other molecules in the cell. Our findings provide new insights into the genomic landscape of CXCR4 in the context of emerging and re-emerging diseases, which could inform the development of more effective treatments or prevention strategies. Overall, our study sheds light on the vital role of CXCR4 in mammalian health and disease, highlighting its potential as a therapeutic target for various diseases impacting human and animal health. These findings provided insight into the study of human immunological disorders by indicating that Chemokines may have activities identical to or similar to those in humans and several mammalian species.

10.3390/vaccines11030671

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Assessing anticancer, antidiabetic, and antioxidant capacities in green-synthesized zinc oxide nanoparticles and solvent-based plant extracts

Heliyon (2024)

Muhammad Azeem Muhammad Hussnain Siddique Muhammad Imran Muhammad Zubaır Rabia Mumtaz

Cancer and diabetes represent significant challenges in the field of biomedicine, with major and global impacts on public health. Acacia nilotica, commonly called 'gum arabic tree,' is recognized for its unique biomedical properties. The current study aimed to investigate the pharmacological potential of A. nilotica-based zinc-oxide nanoparticles (ZnO-NPs) in comparison to the ethanol and methanol-based extracts against cancer, diabetes, and oxidative stress. Green synthesis of ZnO-NPs was performed using barks of Acacia nilotica. Different techniques for the characterization of ZnO-NPs, including UV–Visible spectroscopy, Scanning Electron Microscopy, Fourier Transmission Infrared (FT-IR) spectroscopy, and X-ray Diffraction (XRD), were utilized. The morphological analysis of ZnO-NPs revealed that the fine NPs have mean particle sizes of 15 ± 1.5 nm. For the solvent based-extraction, leaves and barks were utilized and dissolved into ethanol and methanol for further processing. The MTT assay revealed that the optimum concentration of ZnO-NPs to inhibit the proliferation of liver cancer cell line HepG2 was 100 μg/mL where 67.0 % inhibition was observed; and both ethanol- and methanol-based extracts showed optimum inhibition at 100 μg/mL. The DPPH assay further demonstrated that 250 μg/mL of ZnO-NPs and 1000 μg/mL of both ethanol- and methanol-based extracts, as the optimum concentration for antioxidant activity (with 73.1 %, 68.9 % and 68.2 % inhibition respectively). The α-Glucosidase inhibition assay revealed that 250 μg/mL of ZnO-NPs and 10 μg/mL of both ethanol- and methanol-based extracts as the optimum concentration for antidiabetic activity (with 95 %, 93.7 % and 93.4 % inhibition respectively). The study provided interesting insights into the efficacy and reliability of ZnO-NPs for potential pharmacological application. Further research should be focused on examining specific pathways and the safety of ZnO-NPs in comparison to solvent-based extracts.

MTT assay

10.1016/j.heliyon.2024.e34073

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Citations (2)

Is Is IT Revolution and Digitalization a Curse? A Comprehensive Model of Turnover Intention in the Private Banking Sector of Pakistan

journal of social sciences review (2023)

Muhammad Naeem Shahid Rabia Mumtaz Tehseen Azhar Shahid Mehmood Jawad Khalil

Digitalization decreases job satisfaction by increasing pressure, fear of job loss, and deteriorating work-life balance. The study investigates the nexus of customer incivility, workplace incivility, employee religious perception, digitalization, HRM practices, and employee turnover intention in the presence of practical commitment as a mediator and servant leadership as a moderator. Further, the current study also examines the relationship between practical commitment and employee turnover intention. Data was collected through a self-administrator questionnaire from frontline employees of private banks in Punjab, Pakistan. Data analysis was done through SPSS and PLS software. The current study results have revealed that WPI, CI, ERP, DEG, and HRM practices are significantly associated with employees’ job attitudes, such as EC and TI. Further, Effective commitment positively mediates relationships. Moreover, servant leadership successfully moderates the relationship between EC and TI. In light of the above results, the current study recommended that WPI, CI, ERP, DEG, and HRM practices are significant factors for the future success of the service sector in developing countries like Pakistan. The current study contributes to the literature on Change, IT revolution, digitalization, and its adverse effects through the lens of resource conservation theory to explain the phenomena of turnover intention framework, which is the uniqueness of the current study.

Moderation

10.54183/jssr.v3i2.346

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Citations (1)

Green synthesis and characterization of silver nanoparticles from Acacia nilotica and their anticancer, antidiabetic and antioxidant efficacy

Environmental Pollution (2022)

Muhammad Zubaır Muhammad Azeem Rabia Mumtaz Madiha Younas Muhammad Adrees

Silver nanoparticle

10.1016/j.envpol.2022.119249

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Citations (51)

TOMATO GENES EXPRESS DIFFERENTIALLY IN RESPONSE TO FUNGAL ATTACK

PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY (2022)

Saba Riaz Rabia Mumtaz Ali Razzaq Fozia Saleem

Tomato (Solanum lycopersicum) belongs to family Solanaceae that comprises more than 3000 species. Several studies are reported on various aspects of tomato genome. However, many important molecular processes have still not been studied in this important plant. Effect of fungal stress on differential gene expression was studied with the help of arbitrary primers. Differential gene expression under fungal infection showed expression of many genes that may have important implications; the expressed genes have been categorized in three categories viz. genes related to cellular metabolism, genes corresponding to defense related proteins and the genes related to poly(A) factors. Outcome of the project is expected to have important implications for the control of gene expression in tomato to improve yields and varieties.

10.56557/pcbmb/2022/v23i27-287738

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Comparative Efficacy of Constrained Induced Movement Therapy and Motor-Relearning Program in Post Stroke Upper Extremity Function

Journal of Health and Rehabilitation Research (2023)

Rameen Mahboob Malik Muhammad Atif Rabia Ehsan N. Nazir Rabia Mumtaz

Background: Stroke often leads to significant impairments in motor function, particularly in the upper extremities. Constraint-Induced Movement Therapy (CIMT) and Motor Relearning Program (MRP) are two rehabilitation approaches that have shown potential in addressing these deficits. This study aimed to compare the effectiveness of these two therapies in improving upper extremity function in post-stroke hemiplegia. Objective: To evaluate and compare the efficacy of CIMT and MRP in enhancing motor recovery and functional performance of the upper extremity in patients with post-stroke hemiplegia. Methods: This randomized controlled trial included patients aged 35-60 years diagnosed with ischemic or hemorrhagic stroke, confirmed by CT scans and MRI. Patients were randomly assigned to either the CIMT group or the MRP group, each comprising 16 participants. Both groups underwent respective therapies for two hours daily, six days a week, for four weeks. The Motor Assessment Scale and the Functional Independence Measure (FIM) Scale were employed for pre-, post-, and follow-up evaluations. Results: Both groups showed significant improvements in motor function and daily living activities. The CIMT group exhibited greater advancements, with notable increases in upper extremity strength and active range of motion in the shoulder, elbow, and wrist joints. Quantitative improvements in the CIMT group included an average increase of 2 points in Motor Assessment Scale scores and a 15% improvement in FIM scores. The MRP group demonstrated an average increase of 1.5 points in Motor Assessment Scale scores and a 10% improvement in FIM scores. Conclusion: While both CIMT and MRP are effective in improving motor function and daily living activities in patients with post-stroke hemiplegia, CIMT showed a slight edge in enhancing upper extremity strength and range of motion. These findings suggest that CIMT could be a more efficacious approach in the rehabilitation of upper extremity function in stroke patients.

Constraint-induced movement therapy

Stroke

Functional Independence Measure

10.61919/jhrr.v3i2.282

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Pharmacological activities of Artemisia absinthium and control of hepatic cancer by expression regulation of TGFβ1 and MYC genes

PLoS ONE (2023)

Jannat Sohail Muhammad Zubaır Khadim Hussain Muhammad Faisal Muhammad Ismail

Plant derived compounds have always been an important source of medicines and have received significant attention in recent years due to their diverse pharmacological properties. Millions of plant-based herbal or traditional medicines are used to cure various types of cancers especially due to activation of proliferative genes. The aim of the present study was to characterize the altered and attenuated gene expression of the selected growth factor namely Transforming growth factor Beta -1 (TGFβ1) and MYC in human hepatoma-derived (Huh7) liver cancer cell lines in response to extracts of Artemisia absinthium dissolved in selected organic solvents. Ethanolic, methanolic and acetone extract of different plant parts (leaf, stem and flowers) was used to access the antiproliferative activity by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay. Quantitative Real-Time RT-PCR revealed that the transcript levels of TGFβ1 are induced in the samples treated with methanolic extract of Artemisia absinthium. Furthermore, reduced expression levels of MYC gene was noticed in cancerous cells suggesting antiproliferative properties of the plant. This study further highlights the resistance profile of various microbes by antimicrobial susceptibility test with plant extracts. In addition, antidiabetic effect of Artemisia absinthium have also shown positive results. Our study elucidates the potentials of Artemisia absinthium as a medicinal plant, and highlights the differential expression of genes involved in its mitogenic and anti-proliferative activity with a brief account of its pharmacological action.

Artemisia

MTT assay

10.1371/journal.pone.0284244

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Citations (6)

Extracts of Eucalyptus alba Promote Diabetic Wound Healing by Inhibiting α-Glucosidase and Stimulating Cell Proliferation

Evidence-based Complementary and Alternative Medicine (2022)

Rabia Mumtaz Muhammad Zubaır Muhammad Asaf Khan Saima Muzammil Muhammad Hussnain Siddique

Treatment of diabetic wounds has always been a challenge for primary and acute health care. Eucalyptus alba has been reported to be used for the treatment of wounds and oxidative stress. Effects of using different temperatures and solvents for the extraction of Eucalyptus alba leaves were investigated in terms of diabetic wound healing activity. Leaves of E. alba were dried at 10°C, 30°C, 50°C, and 100°C, and dissolved in ethanol, methanol, and acetone to obtain a total of 12 extracts. All the extracts have remarkable antidiabetic, antioxidant, and cell proliferation activities. Among the tested extracts, highest activities were observed with leaves dried at 10°C and 30°C, whereas drying at 100°C resulted in the lowest activities. Ethanol-based extracts exhibited significantly increased cell proliferation compared with methanol- and acetone-based extract. The present study suggests that leaves of E. alba should be dried at temperature not more than 30°C and extracted in ethanol for optimum results. However, further studies should focus on the identification of specific bioactive compounds in E. alba leaves.

10.1155/2022/4953105

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Citations (15)