Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe and under-recognized complication of acute pulmonary embolism (PE). Forty consecutive patients with acute PE (Group 1), predominantly female (22, 55%) with a mean age of 69 ± 15 years, were matched for demographic data with 40 healthy subjects (Group 2), 40 systemic hypertension patients (Group 3) and 45 prevalent idiopathic pulmonary arterial hypertension (IPAH) patients (Group 4). The baseline evaluation included physical examination, NYHA/WHO functional class, right heart catheterization (RHC) limited to IPAH patients, echocardiographic assessment and systemic arterial stiffness measurement by cardio-ankle vascular index (CAVI). Patients with PE underwent an echocardiographic evaluation within 1 month from hospital discharge (median 27 days; IQR 21–30) to assess the echo-derived probability of PH. The CAVI values were significantly higher in the PE and IPAH groups compared with the others (Group 1 vs. Group 2, p < 0.001; Group 1 vs. Group 3, p < 0.001; Group 1 vs. Group 4, p = ns; Group 4 vs. Group 2, p < 0.001; Group 4 vs. Group 3, p < 0.001; Group 2 vs. Group 3, p = ns). The predicted probability of echocardiography-derived high-risk criteria of PH increases for any unit increase of CAVI (OR 9.0; C.I.3.9–20.5; p = 0.0001). The PE patients with CAVI ≥ 9.0 at the time of hospital discharge presented an increased probability of PH. This study highlights a possible positive predictive role of CAVI as an early marker for the development of CTEPH.

Group B

10.3390/jcm10143008

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MODERATED ECASES - SESSION I

European Heart Journal - Cardiovascular Imaging (2017)

Camilla Torlasco Giulia Benedetti James Moon Marina Hughes Vera Lucia Paiocchi

Objectives: A 57yo, asymptomatic, healthy woman enrolled for the London Marathon as a 1st-time runner and entered the MARATHON2 study, including CMR and CPET.Cardiac MRI showed a right-sided aortic arch with aberrant left subclavian artery originating from a Kommerel's diverticulum (28mm) posterior to the esophagus and trachea.This potentially creates a vascular ring, completed with the ligamentum arteriosum.The patient, who exercised 2-3hours per week, denied cough, dyspnea or dysphagia.Images showed no signs of compression of the trachea or mediastinal structures.The descending aorta crossed the midline to the left at diaphragm level.Normal aortic diameters, heart function and structure.ECG/BP were normal in both upper limbs.Good exercise capacity at CPET (ramp¼20W/min): exercise time¼13'35'', peak VO2¼21.6ml/Kg/min,peak breathing reserve¼34%, peak RQ¼ 1.23.Normal BP/HR response.No symptoms.A right-sided aortic arch is a rare congenital defect (0.05-0.1%), associated with aberrant left subclavian in 50%of cases,(1) originating from the disappearance of the fourth arch on

10.1093/ehjci/jex104

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Late Gadolinium Enhancement is useful not only in the heart: a new tool to reveal skeletal muscle involvement in idiopathic inflammatory myopathies

Giulia Benedetti Antonio Esposito Maurizio La Cava Mario P. Colombo G. A. Ramirez

Poster: ESCR 2015 / P-0021 / Late Gadolinium Enhancement is useful not only in the heart: a new tool to reveal skeletal muscle involvement in idiopathic inflammatory myopathies by: G. Benedetti 1, A. Esposito1, M. Cava1, M. colombo1, G. A. Ramirez1, D. Velardo1, A. Manfredi2, E. Bozzolo1, S. Previtali1, P. Rovere Querini1, A. Del Maschio1, F. De Cobelli1; 1Milan/IT, 2Milano/IT

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CT-derived radiomic features to discriminate histologic characteristics of pancreatic neuroendocrine tumors

La radiologia medica (2021)

Giulia Benedetti Martina Mori Marta Panzeri Maurizio Barbera Diego Palumbo

10.1007/s11547-021-01333-z

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Citations (80)

[Clinical aspects of the physiopathology of the ischemic event in clinical medicine].

PubMed (1986)

A Dagianti F Fedele Maria Penco Luciano Agati Di Renzi L

Pathophysiology

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[Use of bacampicillin in the therapy of otorhinolaryngologic infections].

PubMed (1984)

Giulia Benedetti Ana Carolina Faria e Silva Santelli Marta Gatti Ruffilli Mp U Ecari

Otorhinolaryngologic Diseases

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Two years’ effect of dimethyl fumarate on focal and diffuse gray matter pathology in multiple sclerosis

Multiple Sclerosis Journal (2022)

Damiano Marastoni Francesco Crescenzo Anna Isabella Pisani Carmela Zuco Gianmarco Schiavi

Data on the effect of dimethyl fumarate (DMF) on focal and diffuse gray matter (GM) damage, a relevant pathological substrate of multiple sclerosis (MS)-related disability are lacking.To evaluate the DMF effect on cortical lesions (CLs) accumulation and global and regional GM atrophy in subjects with relapsing-remitting MS.A total of 148 patients (mean age 38.1 ± 9.7 years) treated with DMF ended a 2-year longitudinal study. All underwent regular Expanded Disability Status Scale (EDSS assessment), and at least two 3T-magnetic resonance imaging (MRI) at 3 and 24 months after DMF initiation. CLs and changes in global and regional atrophy of several brain regions were compared with 47 untreated age and sex-matched patients.DMF-treated patients showed lower CLs accumulation (median 0[0-3] vs 2[0-7], p < 0.001) with respect to controls. Global cortical thickness (p < 0.001) and regional thickness and volume were lower in treated group (cerebellum, hippocampus, caudate, and putamen: p < 0.001; thalamus p = 0.03). Lower relapse rate (14% vs 40%, p < 0.001), EDSS change (0.2 ± 0.4 vs 0.4 ± 0.9, p < 0.001), and new WM lesions (median 0[0-5] vs 2[0-6], p < 0.001) were reported. No severe adverse drug reactions occurred.Beyond the well-known effect on disease activity, these results provide evidence of the effect of DMF through reduced progression of focal and diffuse GM damage.

Dimethyl fumarate

Putamen

10.1177/13524585221104014

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Citations (6)