N. Vijay

Trichy SRM Medical College Hospital and Research Centre

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V. Saikumari

K. Sakthipandi

SRM Institute of Science and Technology

G. Rajkumar

Indian Institute of Technology Kharagpur

Mohammad Ibrarullah

Apollo Hospitals

V. Dhivya

KS Rangasamy College of Arts and Science

Sekar Mahalaxmi

SRM Dental College

Narayan Hegde

BAIF Development Research Foundation

Siva Kumar A.

Trichy SRM Medical College Hospital and Research Centre

Gajanan D Wagholikar

Deenanath Mangeshkar Hospital and Research Center

R. Priyatharshini

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SRM Institute of Science and Technology

SRM Dental College

Anna University, Chennai

SRM University

Indian Institute of Technology Madras

Sri Venkateswara Institute of Medical Sciences

Sri Ramachandra Institute of Higher Education and Research

Sanjay Gandhi Post Graduate Institute of Medical Sciences

Trichy SRM Medical College Hospital and Research Centre

Indian Institute of Science Bangalore

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Efficacy of zoledronic acid infusion on bone mineral density among adult population

International Journal of Research in Orthopaedics (2019)

N. Vijay Siva Kumar A.Cyril Jonnes S.

Background: Osteoporosis is a skeletal disease characterised by impaired bone strength due to reduced bone mineral density. As a consequence, patients with osteoporosis are at increased risk of fractures. Zoledronic acid is an anti-resorptive agent that acts by slowing down osteoclast medicated bone resorption, thereby increasing bone density. This study was carried out to evaluate the efficacy of Zoledronic acid on bone mineral density.Methods: This study was carried out as a record based cross sectional study among 30 symptomatic adult patients who visited the outpatient department of Orthopedics for a period of two years. Bone mineral density (BMD) parameters assessed using dual-energy X-ray absorptiometry (DEXA) scan were documented for initial period and after six months of intervention. Documentation of intervention with single dose of zoledronic acid 5 mg by intravenous infusion was verified and noted.Results: There was a significant difference in the mean scores for both femoral neck and lumbar spine with respect to BMD values and T-score values between baseline parameters and values measured after 6 months of Zoledronic acid infusion. The difference was statistically significant (p<0.05).Conclusions: Single dose of zoledronic acid 5 mg by intravenous infusion was found to be effective in increasing the BMD among individuals suffering from osteopenia and osteoporosis.

Zoledronic Acid

10.18203/issn.2455-4510.intjresorthop20195805

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Retrograde jejuno-jejunal intussusception.

PubMed (2003)

Gajanan D Wagholikar Mohammad Ibrarullah Narayan Hegde N. Vijay

Jejunum

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Effects of strontium-containing fluorophosphate glasses for enhancing bioactivity and enamel remineralization