ABSTRACT Although efficiency robust tests are preferred for genetic association studies when the genetic model is unknown, their statistical properties have been studied for different study designs separately under special situations. We study some statistical properties of the maximin efficiency robust test and a maximum‐type robust test (MAX3) under a general setting and obtain unified results. The results can also be applied to testing hypothesis with a constrained two‐dimensional parameter space. The results are applied to genetic association studies using case–parents trio data.
Management focuses on some basic issues of management activities,which is an active discipline during the history of science studies,its theories retread continuously and emerge in endlessly.The paper takes the papers in 10 representative journals in management as research object,reveals organizational behavior theory,Organizational structural theory and Strategic management theory dominant the management theory fronts at present through applying the document co-citation analysis,kwt words co-occurrence analysis and the theory and approach of mapping knowledge domains.
This article describes research carried out during 2023 under an International Society for Photogrammetry and Remote Sensing (ISPRS)-funded project to develop and disseminate a metadata catalogue of Earth observation data sources/products and types that are relevant to human health research in exposomics, as a free service to interested researchers worldwide. The proof-of-concept catalogue was informed by input from existing research literature on the subject (desk research), as well as online communications with, and relevant research publications collected from, a small panel (n = 5) of select experts from the academia in three countries (China, UK and USA). It has 90 metadata records of relevant Earth observation datasets (n = 40) and associated health-focused research publications (n = 50). The project's online portal offers a searchable version of the catalogue featuring a number of search modes and filtering options. It is hoped future, more comprehensive versions of this service will enable more researchers and studies to discover and use remote sensing data about population-level exposures to disease determinants (exposomic determinants of disease) in combination with other relevant data to reveal fresh insights that could improve our understanding of relevant diseases, and hence contribute to the development of better-optimized prevention and management plans to tackle them.
We recently developed a mouse model of hepatitis B virus (HBV) chronic infection by intravenous (i.v.) injection with rAAV8-1. 3HBV to C57BL/6 mice. To define the responses of different mouse strains after injection with rAAV8-1. 3HBV, we intravenously injected rAAV8-1. 3HBV at doses of 4 x10(9) (Viral genome,vg), 4 x 10(10) vg and 4 x 10(11) vg to C57BL/6 and BALB/c mice,respectively, and determined the levels of serum HBV antigen and antibody by ELISA,serum viral DNA by real-time PCR,and HBcAg expression in liver by immunohistochemical staining. For C57BL/6 mouse strain with injection of rAAV8-1. 3HBV at three doses, 100% of the mice carried HBV for more than 8 months. The levels of serum HBsAg and HBeAg, serum viral DNA and HBcAg-positive hepatocytes increased in a rAAV8-1. 3HBV dose-dependent manner. For C57BL/6 mice injected with rAAV8-1. 3HBV at the dose of 4 x 10(11) vg,over 40% of hepatocytes expressed HBcAg and serum viral DNA reached over 10(5) IU/mL. No HBV antibody was detected in sera of C57BL/6 mice. For BALB/c mice with injection of rAAV8-1. 3HBV at three doses, serum HBeAg, serum viral DNA and HBcAg-positive hepatocytes persisted for more than 8 months, but serum HBsAg declined remarkably at 2 weeks after injection. The levels of serum HBeAg and HBcAg-positive hepatocytes in BALB/c mice increased in a rAAV8-1. 3HBV dose-dependent manner. Injection with rAAV8-1. 3HBV at the dose of 4 x 10(11) vg resulted in over 50% of BALB/c mice hepatocytes expressing HBcAg. Serum anti-HBsAg were detected in BALB/c mice with rAAV8-1. 3HBV injection at the dose of 4 x10 (10) vg. In conclusion, both C57BL/6 and BALB/c strains can be developed to chronic HBV infection mouse models by i. v. injection with rAAV8-1. 3HBV at doses of 4 x10(9) - 4 x 10(11) vg and the levels of HBV replication increase in a rAAV8-1. 3HBV dose-dependent manner. In contrast to C57BL/6 strain, the BALB/c mice carry out humoral immunity to HBsAg, but fail to mediate HBV clearance.
More and more attention has been given in the field of mechanical engineering to a material’s R-value, a parameter that characterizes the ability of sheet metal to resist thickness strain. Conventional methods used to determine R-value are based on experiments and an assumption of constant volume. Because the thickness strain cannot be directly measured, the R-value is currently determined using experimentally measured strains in the width, and loading directions in combination with the constant volume assumption, to determine the thickness strain indirectly. This paper provides an alternative method for determining the R-value without any assumptions. This method is based on the use of a multi-camera DIC system to measure strains in three directions simultaneously. Two sets of stereo-vision DIC measurement systems, each comprised of two GigE cameras, are placed on the front and back sides of the sample. Use of the double-sided calibration strategy unifies the world coordinate system of the front and back DIC measurement systems to one coordinate system, allowing for the measurement of thickness strain and direct calculation of R-value. The Random Sample Consensus (RANSAC) algorithm is used to eliminate noise in the thickness strain data, resulting in a more accurate R-value measurement.
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