Bochra Kouidhi

University of Monastir

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Kamel Chaieb

King Abdulaziz University

Amina Bakhrouf

University of Monastir

Tarek Zmantar

University of Monastir

Kacem Mahdouani

University of Monastir

Fadia Ben Taheur

University of Monastir

Rihab Ben Slama

Centre National de la Recherche Scientifique

Kais Fdhila

University of Monastir

Hanene Miladi

University of Monastir

Hajer Hentati

University of Monastir

Yasir Mohammed A. Al Qurashi

Shaqra University

Cooperative Institutions

University of Monastir

King Abdulaziz University

Taibah University

Office of Livestock and Pasture

University of Jendouba

Laboratoire des Sciences de l'Ingénieur pour l'Environnement

King Abdul Aziz University Hospital

Jeddah University

Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement

University of Sfax

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Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation

BMC Complementary and Alternative Medicine (2011)

Kamel Chaieb Bochra Kouidhi Hanene Jrah Kacem Mahdouani Amina Bakhrouf

Thymoquinone is an active principle of Nigella sativa seed known as "Habbah Al-Sauda" in Arabic countries and "Sinouj" in Tunisia. Bacterial biofilms tend to exhibit significant tolerance to antimicrobials drugs during infections.The antibacterial activity of Thymoquinone (TQ) and its biofilm inhibition potencies were investigated on 11 human pathogenic bacteria. The growth and development of the biofilm were assessed using the crystal violet (CV) and the 2, 3-bis [2-methyloxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxanilide (XTT) reduction assay.TQ exhibited a significant bactericidal activity against the majority of the tested bacteria (MICs values ranged from 8 to 32 μg/ml) especially Gram positive cocci (Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis CIP 106510). Crystal violet assay demonstrated that the minimum biofilm inhibition concentration (BIC50) was reached with 22 and 60 μg/ml for Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis CIP 106510 respectively. In addition our data revealed that cells oxidative activity was influenced by TQ supplementation. In the same way, TQ prevented cell adhesion to glass slides surface.The ability of TQ to prevent biofilm formation warrants further investigation to explore its use as bioactive substances with antibiofilm potential.

Thymoquinone

Nigella sativa

Crystal violet

10.1186/1472-6882-11-29

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Citations (337)

Aflatoxin B1 degradation by microorganisms isolated from Kombucha culture

Toxicon (2020)

Fadia Ben Taheur Chalbia Mansour Khawla Ben Jeddou Yasmine Machreki Bochra Kouidhi

Artemia salina

Brine shrimp

10.1016/j.toxicon.2020.03.004

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Citations (46)

Use of carvacrol, thymol, and eugenol for biofilm eradication and resistance modifying susceptibility of Salmonella enterica serovar Typhimurium strains to nalidixic acid

Microbial Pathogenesis (2017)

Hanene Miladi Tarek Zmantar Bochra Kouidhi Yassine Chaabouni Kacem Mahdouani

Carvacrol

Salmonella enterica

Thymol

Ethidium bromide

Efflux

10.1016/j.micpath.2017.01.012

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Citations (95)

Drug resistance of bacterial dental biofilm and the potential use of natural compounds as alternative for prevention and treatment

Microbial Pathogenesis (2015)

Bochra Kouidhi Yasir Mohammed A. Al Qurashi Kamel Chaieb

Dental plaque

Oral microbiology

Fusobacterium nucleatum

Actinobacillus

Prevotella intermedia

Streptococcus gordonii

Fusobacterium

10.1016/j.micpath.2015.02.007

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Citations (168)

Use of lactic acid bacteria for the inhibition of Aspergillus flavus and Aspergillus carbonarius growth and mycotoxin production

Toxicon (2019)

Fadia Ben Taheur Chalbia Mansour Bochra Kouidhi Kamel Chaieb

Growth inhibition

10.1016/j.toxicon.2019.05.004

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Citations (61)

Cytotoxicity, Antibacterial, Antioxidant, and Antibiofilm Properties of TunisianJuglans regiaBark Extract

Journal of Herbs Spices & Medicinal Plants (2013)

Kamel Chaieb Bochra Kouidhi Rihab Ben Slama Kais Fdhila Tarek Zmantar

Tunisian Juglans regia bark ethanol extract (JREE) was examined for antibacterial, antibiofilm, and antioxidant activity. Its anti-proliferative effect was evaluated on normal (MRC-5) and cancer (HT29 and HEp-2) cell lines. The data revealed that JREE inhibited the growth of pathogenic bacteria (MICs value ranged from 32 to 128 μg.mL-1) and induced a strong antibiofilm effect (BIC50 was 23, 30, and 43 μg.mL-1 for Micrococcus luteus, Staphylococcus epidermidis, and Staphylococcus aureus, respectively). The JREE showed high scavenging property against 2,2-diphenyl-l-1-picrylhydrazil (DPPH) radical (IC50 = 3.5 μg.mL-1) and exhibited anti-proliferative effects with IC50 values ranging from 6.6 to 25.5 μg.mL-1.

Micrococcus luteus

ABTS

10.1080/10496475.2012.762818

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Citations (12)

Identification of antimicrobial bioactive peptides from the camel milk protein lactoferrin: molecular docking, molecular dynamic simulation, and in vitro study.

Food and Humanity (2024)

Mohammed Alzain Ehab M. M. Ali Mazin A. Zamzami Ishtiaq Qadri Hani Choudhry

Lactoferrin

Docking (animal)

10.1016/j.foohum.2024.100414

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Citations (2)

Modulation of drug resistance and biofilm formation of Staphylococcus aureus isolated from the oral cavity of Tunisian children

The Brazilian Journal of Infectious Diseases (2016)

Tarek Zmantar Rihab Ben Slama Kais Fdhila Bochra Kouidhi Amina Bakhrouf

This study aims to investigate the antimicrobial and the anti-biofilm activities of Lactobacillus plantarum extract (LPE) against a panel of oral Staphylococcus aureus (n=9) and S. aureus ATCC 25923. The in vitro ability of LPE to modulate bacterial resistance to tetracycline, benzalchonium chloride, and chlorhexidine were tested also.The minimum inhibitory concentrations (MICs) and the minimal bactericidal concentrations of Lactobacillus plantarum extract, tetracycline, benzalchonium chloride and clohrhexidine were determined in absence and in presence of a sub-MIC doses of LPE (1/2 MIC). In addition, the LPE potential to inhibit biofilm formation was assessed by microtiter plate and atomic force microscopy assays. Statistical analysis was performed on SPSS v. 17.0 software using Friedman test and Wilcoxon signed ranks test. These tests were used to assess inter-group difference (p<0.05).Our results revealed that LPE exhibited a significant antimicrobial and anti-biofilm activities against the tested strains. A synergistic effect of LPEs and drug susceptibility was observed with a 2-8-fold reduction.LPE may be considered to have resistance-modifying activity. A more detailed investigation is necessary to determine the active compound responsible for therapeutic and disinfectant modulation.

Modulation (music)

10.1016/j.bjid.2016.10.009

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Citations (16)

Enhanced textile dye removal from wastewater using natural biosorbent and Shewanella algae B29: Application of Box Behnken design and genomic approach

Bioresource Technology (2023)

Kamel Chaieb Bochra Kouidhi Lamia Ayed Salman Hosawi Jawaher Abdulbaqi Abdulhakim

Halotolerance

Box–Behnken design

Biosorption

10.1016/j.biortech.2023.128755

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