M. Kubota

Gifu University

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Co-Authors

Itsushi Baba

Hiroshima City Asa Citizens Hospital

Tadashi Nakano

Jikei University School of Medicine

Takaaki Hayashi

Katsushika Medical Center

Susumu Yamamoto

Matsuyama Red Cross Hospital

Yoshinori Fujimoto

Tokyo Institute of Technology

Kaoru Yoshioka

Sapporo Medical University Hospital

T. Ohsugi

Hiroshima University

Tomoyuki Watanabe

Jikei University School of Medicine

Yoshitaka Hagiyama

Saiseikai Matsuyama Hospital

Tadayuki Sumida

Hiroshima City Asa Citizens Hospital

Cooperative Institutions

Hiroshima University

Jikei University School of Medicine

Osaka University

Matsuyama Red Cross Hospital

The University of Tokyo

Tohoku University

Kyoto University

Tokyo Institute of Technology

Panasonic (Japan)

Kobe University

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Sxes Study of Transition Metal Silicide Films and their Contacts to Semiconductors

MRS Proceedings (1990)

H. Watabe M. Iwami Masaaki Hirai M. Kusaka M. Kubota

10.1557/proc-187-173

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Citations (1)

Effects of photodynamic therapy plus intravitreal aflibercept with subtenon triamcinolone injections for aflibercept-resistant polypoidal choroidal vasculopathy

Graefe s Archive for Clinical and Experimental Ophthalmology (2017)

Tsutomu Sakai Noriko Kato M. Kubota Hiroshi Tsuneoka

Aflibercept

Choroid

10.1007/s00417-017-3700-3

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Citations (3)

Intraspinal Medulloblastoma, A Case Report

Orthopedics & Traumatology (1980)

M. Kubota Itsushi Baba Masayoshi Shimamura Kenichi Harada Masashi Naito

The authors reported a case of the spinal tumor which was considered to be a primary intraspinal medulloblastoma.27 year-old male was admitted with the complaints of paraplesia and myelographic examination showed the space occupying lesion at the 4th & 5th thoracic vertebrae.Twice operations were carried out due to the recurrence in the same location.Histologically the tumor was revealed medulloblastoma.11 months after the onset, the symptoms is completely relieved and there is no evidence of the intracranial involvement.

Thoracic vertebrae

10.5035/nishiseisai.28.551

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On the Old Cases of Atlanto-Axial Disorders with Wry Neck

Orthopedics & Traumatology (1976)

Sachiko Yamamoto Yasuo Murakami Itsushi Baba M. Kubota Takashi Kubo

Rotary fixation and locking rotary dislocation of atlanto-axial joint after inflammation or trauma are well known as a cause of the wry neck.Authors report each case of the rotary fixation and locking rotary dislocation treated recently and discuss some clinical problems.

Atlanto-axial joint

Joint dislocation

10.5035/nishiseisai.25.402

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Clinical Study of Treatment of Metastatic Cervical Column Tumor

Orthopedics & Traumatology (1975)

Kengo Fujii Yasuo Murakami Itsushi Baba S Watari M. Kubota

From 1963 to 1974, the authors have treated 58 cases of spinal column tumors. Among of them, there were 13 cases of cervical column tumors, 12 of which were metastasis. This paper is about the 12 cases of metastasis. 8 cases were male and 4 cases were female. Age distribution was from 28 to 72 and average was 53.2. Primitive tumor was mamma (2 cases), stomach (2 cases), thyroid, grawitz tumor, uterus, prostata, bladder, (each one case), giant cell tumor of femur (I case) and 2 origin unknoun.Radiography have shown; collapse vertebre & disapper of normal alignment, in some cases, kyphosis (6 cases) or angulation myelopathy (4 cases) were very important, one case was in relation with protrusion of metastatic bone in the spinal canal.Cuppetage and bone graft was carried out in 3 cases, laminectomy in 2 cases, radiation and skeletal traction each one case. We had good result for mamma metastasis.

Spinal column

Kyphosis

Vertebral column

10.5035/nishiseisai.24.318

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A position-sensitive radiation detector using a heterojunction of amorphous and crystalline silicon

Nuclear Instruments and Methods in Physics Research Section A Accelerators Spectrometers Detectors and Associated Equipment (1990)

Yasuo Chiba I. Endo M. Kubota T. Ohsugi Shinsuke Okada

Nanocrystalline silicon

Particle detector

Position (finance)

10.1016/0168-9002(90)90766-y

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Citations (10)

CCDC 172061: Experimental Crystal Structure Determination

The Cambridge Structural Database (2003)

Hideyuki Higashimura M. Kubota Akinobu Shiga K. Fujisawa Y. Moro-Oka

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc5s1cb

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Vision Improvement after Osimertinib Treatment in Paraneoplastic Optic Neuropathy Associated with Lung Adenocarcinoma

Case Reports in Ophthalmological Medicine (2021)

M. Kubota Nobumasa Tamura Takaaki Hayashi Euido Nishijima Haruhiko Yanagisawa

Treatments for paraneoplastic optic neuropathy (PON), a tumor-related autoimmune disease, include immunosuppression, plasma exchange, and immunoglobulin therapies, as well as treatment of the underlying disease. Herein, we describe the clinical course of an older adult patient with PON whose loss of vision improved after switching between epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatments for cancer. A 76-year-old woman, who had been treated with gefitinib for lung adenocarcinoma for two years, presented with acute bilateral visual disturbances. Her decimal best-corrected visual acuity (BCVA) was 0.3 in the right eye (RE) and 0.7 in the left eye (LE). Slit-lamp examination and funduscopy showed no abnormal findings. Two weeks later, her BCVA decreased to 0.2 in the RE and 0.01 in the LE. Goldman’s perimetry showed a defect in the lower nasal RE and extensive visual-field loss in the LE. Single-flash electroretinograms showed normal amplitudes. Magnetic resonance imaging revealed left optic neuritis and showed neither metastatic cancer nor multiple sclerosis. Pattern-reversal visual evoked potentials showed decreased P100 amplitudes in both eyes (BE). Based on a diagnosis of PON from clinical findings, methylprednisolone pulse treatment was administered. However, her BCVA became no light perception in BE two months after the first visit. Because the tumor tissue was found to be positive for the EGFR T790M resistance mutation by bronchoscopy, the EGFR-TKI treatment was changed to osimertinib, decreasing the size of the lung cancer lesions. Her BCVA improved to hand motion in BE. Her final BCVA was 0.01 in the RE, counting fingers 10 cm in the LE. She died at the age of 79 years. To our knowledge, no reports have shown improvement in BCVA in patients with PON after changing EGFR-TKI treatments. This report indicates that some patients may develop severe visual dysfunction without early treatment for the primary tumor.

Osimertinib

10.1155/2021/2832021

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Citations (1)

Association between personality traits and experience of adverse periocular reactions to topical prostaglandin analogues

BMJ Open Ophthalmology (2022)

Nanami Kishimoto Takahiko Noro Fumitoshi Kodaka Mei Kurosawa Yoshinori Itoh

Aesthetically unappealing adverse periocular reactions to prostaglandin (PG) eye-drops are a major challenge in glaucoma treatment. This study analysed the personality traits of patients with glaucoma based on a five-factor model and examined the associations between these factors and adverse periocular reactions.One hundred and forty-seven patients with glaucoma were surveyed anonymously regarding their personality traits and how often adverse periocular reactions were experienced.The analysis included 117 valid responses (71 men and 46 women, age: 61.9±11.5 years). Patients who experienced hypertrichosis of the eyelashes scored significantly higher on extraversion (p<0.05), with no significant differences in the other four personality traits. Patients who experienced eyelid hyperpigmentation and deepening of the upper eyelid sulcus showed no significant differences in any of the personality traits. Younger patients scored significantly higher on hypertrichosis (p<0.05).The experience of adverse reactions differed according to patient age and personality traits. Therefore, eye-drops should be chosen based on these factors.UMIN000035155.

Association (psychology)

10.1136/bmjophth-2021-000946

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Three case of multiple neurilemmoma.

Orthopedics & Traumatology (1988)

Hisashi Ueda Kaoru Yoshioka Yoshinori Fujimoto Katushi Tatsukawa Kouichi Daisaku

Three patients with multiple neurilemmoma are presented. None of them have affected family with von Recklinghausen's disease. Two of them had multiple tumors in one peripheral nerve without café au lait spots. On the basis of this finding, we propose that the pathogenesis of these two cases is partial mutation of cell line of Schwann cell and that they are closely related to von Recklinghausen's desease. The other case is diagnosed as von Recklinghausen's desease (a central form) because of bilateral acoustic tumors.

Pathogenesis

Schwann cell

10.5035/nishiseisai.37.845

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