Carl‐Philipp Heisenberg

Research Field

Dynamics

Tension (geology)

10.3410/f.1208964.674066

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Three Functions of Cadherins in Cell Adhesion

Current Biology (2013)

Jean‐Léon Maître Carl‐Philipp Heisenberg

Cadherins are transmembrane proteins that mediate cell-cell adhesion in animals. By regulating contact formation and stability, cadherins play a crucial role in tissue morphogenesis and homeostasis. Here, we review the three major functions of cadherins in cell-cell contact formation and stability. Two of those functions lead to a decrease in interfacial tension at the forming cell-cell contact, thereby promoting contact expansion--first, by providing adhesion tension that lowers interfacial tension at the cell-cell contact, and second, by signaling to the actomyosin cytoskeleton in order to reduce cortex tension and thus interfacial tension at the contact. The third function of cadherins in cell-cell contact formation is to stabilize the contact by resisting mechanical forces that pull on the contact.

Contact inhibition

Cell Cortex

10.1016/j.cub.2013.06.019

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Citations (294)

Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail

Developmental Biology (2011)

Richard H. Row Jean‐Léon Maître Benjamin L. Martin Petra Stockinger Carl‐Philipp Heisenberg

Germ layer

Epiblast

Brachyury

Intermediate mesoderm

Lateral plate mesoderm

10.1016/j.ydbio.2011.03.025

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Citations (42)

Wnt Signalling: A Moving Picture Emerges From van gogh

Current Biology (2002)

Carl‐Philipp Heisenberg Masazumi Tada

Convergent extension

Dishevelled

10.1016/s0960-9822(02)00704-2

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Citations (21)

Faculty Opinions recommendation of Monomeric α-catenin links cadherin to the actin cytoskeleton.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)

Carl‐Philipp Heisenberg Julien Compagnon

10.3410/f.717979707.793472960

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Faculty Opinions recommendation of Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2010)

Carl‐Philipp Heisenberg Ekaterina Papusheva

10.3410/f.3437967.3131066

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Finite-size corrections to scaling behavior in sorted cell aggregates

The European Physical Journal E (2010)

Abigail Klopper Gabriel Krens Stephan W. Grill Carl‐Philipp Heisenberg

Multicellular organism

Cell Sorting

Pattern Formation

Germ layer

10.1140/epje/i2010-10642-y

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Citations (18)

Zebrafish gastrulation movements: bridging cell and developmental biology

Seminars in Cell and Developmental Biology (2002)

Carl‐Philipp Heisenberg Masazumi Tada

Germ layer

Convergent extension

Epiblast

Ingression

10.1016/s1084952102001003

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Citations (42)

YAP is essential for tissue tension to ensure vertebrate 3D body shape

Nature (2015)

Sean Porazinski Huijia Wang Yoichi Asaoka Martin Behrndt Tatsuo Miyamoto

10.1038/nature14215

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Citations (247)

Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Feyza Nur Arslan Édouard Hannezo Jack Merrin Martin Loose Carl‐Philipp Heisenberg

Abstract Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and time play a central role in cell-cell contact formation and maturation. Yet, how this process is mechanistically achieved remains unclear. Here, by building a biomimetic assay composed of progenitor cells adhering to supported lipid bilayers functionalized with E-cadherin ectodomains, we show that cortical Actin flows, driven by the depletion of Myosin-2 at the cell contact center, mediate the dynamic reorganization of adhesion receptors and cell cortex at the contact. E-cadherin-dependent downregulation of the small GTPase RhoA at the forming contact leads to both a depletion of Myosin-2 and a decrease of F-actin at the contact center. This depletion of Myosin-2 causes centrifugal F-actin flows, leading to further accumulation of F-actin at the contact rim and the progressive redistribution of E-cadherin from the contact center to the rim. Eventually, this combination of actomyosin downregulation and flows at the contact determine the characteristic molecular organization, with E-cadherin and F-actin accumulating at the contact rim, where they are needed to mechanically link the contractile cortices of the adhering cells.

Cell Cortex

10.1101/2023.04.11.536411

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Citations (1)

Carl‐Philipp Heisenberg

Papers

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