Suraj B. Patel

Shivaji University

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Savaliram G. Ghane

Shivaji University

Shreedhar S. Otari

Shivaji University

Rahul L. Zanan

Savitribai Phule Pune University

Manoj M. Lekhak

Shivaji University

Anshu Rastogi

University of Life Sciences in Poznań

Vijay Kumar

Regeneron (United States)

U. A. Attar

Shivaji University

Amiya Kumar Patel

Sambalpur University

Sunil Mistry

Apex Heart Institute

D. M. Sakate

Central University of Tamil Nadu

Cooperative Institutions

Shivaji University

Savitribai Phule Pune University

Apex Heart Institute

Post Graduate Institute of Medical Education and Research

Sambalpur University

Indian Veterinary Research Institute

Shri Vile Parle Kelavani Mandal

American Pharmacists Association

Central University of Tamil Nadu

Augusta University

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Optimization of lycorine using Response Surface Methodology, extraction methods and in vitro antioxidant and anti-diabetic activities from the roots of Giant Spider Lily: A medicinally important bulbous herb

South African Journal of Botany (2022)

Suraj B. Patel Shreedhar S. Otari Vijay Kumar Anshu Rastogi Manoj M. Lekhak

Crinum x amabile Donn ex Ker Gawl. is an ornamental and medicinally important bulbous plant. It is a vital source of an anticancer alkaloid called lycorine (LY). In the present study, LY extraction was enhanced by using Response Surface Methodology (RSM) with Box-Behnken Design (BBD). Optimal responses were recorded at 95% ethanol concentration, 1:30 g/mL SS ratio and 30 min extraction time with the highest recovery of LY (5.84 mg/g DW) when roots were subjected to ultrasonic assisted extraction (UAE). Among tested extraction methods, highest LY content was noted from UAE (3.74±0.00 mg/g DW), while lowest in Soxhlet extraction (1.68±0.007 mg/g DW). Promising antioxidant activities like DPPH (0.10±0.05 mg AAE/g extract), ABTS (2.44±0.04 mg AAE/g extract), FRAP (3.66±0.08 mg Fe (II)E/g extract), and PMA (3.680±0.12 mg AAE/g extract) were recorded from the extract obtained through UAE. Similarly, remarkable α-amylase activity (54.04±0.04 %) and the highest alkaloid content (1.5±0.01 mg SE/g extract) were recorded from the UAE extracts. This study proved that parameters such as SS ratio and extraction time positively influence the extraction of LY. Roots of C. x amabile could be used as a potent source of an anticancer alkaloid and as an innovative drug to control oxidative stress related disorders.

Lycorine

ABTS

10.1016/j.sajb.2022.04.022

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Citations (6)

Luffa Acutangula (Roxb.) L.: An Important Source Of Food And Medicine

Apple Academic Press eBooks (2023)

Suraj B. Patel Shreedhar S. Otari Rahul L. Zanan Savaliram G. Ghane

10.1201/9781003284444_8

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Phytoconstituents and Therapeutic Potential of Barleria prionitis L. Acanthaceae)

Apple Academic Press eBooks (2022)

Shreedhar S. Otari Suraj B. Patel Manoj M. Lekhak Savaliram G. Ghane

Barleria prionitis L. belongs to the family Acanthaceae. It is a medicinally important plant with several common names such as Kuranta (Sanskrit), Vajradanti (Marathi), and Porcupine flower (English). The plant is known by synonyms like Barleria echinata St.-Lag., Barleria hystrix L., Barleria spicata Roxb., Barleria quadripinosa Stokes, Prinonitis hystrix (L.) Miq., Prionitis pubiflora Miq. (POWO, 2021). Barleria prionitis is a perennial shrub, 1 to 2 meters high, leaves ovate or elliptical. Flowers are sessile or solitary with yellow in color. Bracts and calyx are green in color; three to four cm long corolla. Seeds are ovoid in shape. It is distributed in tropical regions of Asia and Africa. It is widely applicable in the therapy of anemia, toothache, cough, fever, asthma, bronchitis, diabetes, insect bites, and inflammations. It is mainly used to cure problems related to teeth and it makes teeth strong (Aneja et al., 2010; Aiswarya et al., 2014). In Thai traditional medicines, it is used against insect bites (Kanchanapoom et al., 2001). The genus has been reported to exhibit biological properties such as antioxidant, acetylcholinesterase (AChE) inhibition, anti-inflammatory, 114antiviral, antibacterial, activities (Amoo et al., 2009; Ata et al., 2007, 2009; Chen et al., 1998; Kalhari et al., 2007; Kapoor et al., 2014).

Acanthaceae

10.1201/9781003281702-10

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Trichosanthes Kirilowii Maxim.: A Pharmacologically Most Active Snake Gourd

Apple Academic Press eBooks (2023)

Suraj B. Patel Shreedhar S. Otari Rahul L. Zanan Savaliram G. Ghane

Maxim

Trichosanthes

10.1201/9781003284444-27

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Phyto-constituents profiling of Luffa echinata and in vitro assessment of antioxidant, anti-diabetic, anticancer and anti-acetylcholine esterase activities

Saudi Journal of Biological Sciences (2021)

Suraj B. Patel Savaliram G. Ghane

Luffa echinata Roxb. is one of the neglected medicinal plants. It is an important source of bioactive metabolites and used in several Ayurvedic formulations. In the present analysis, mature leaves and fruits were extracted with acetone, ethanol, acetonitrile, methanol and water. Phytochemicals like total phenolic (TPC), flavonoid (TFC), tannin (TTC), alkaloid (TAC) and terpenoid (TTEC) content were analysed. Further, antioxidant (AOX) activities like 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis-(3-ethyl) benzothiazoline-6-sulfonic acid (ABTS) radical scavenging, metal chelating activity (MC), ferric reducing antioxidant power (FRAP) and phosphomolybdenum assay (PMA) were studied. Highest TPC and TFC (189.57 ± 1.9 mg TAE/g extract, 30.48 ± 0.7 mg CE/g extract, respectively) were reported from acetone extract of the leaves. Ethanolic fruit extract showed the highest TTC (13.79 ± 0.2 mg CE/g extract). Acetone and acetonitrile fruit extract revealed maximum TTEC (602.79 ± 3.5 mg UAE/g extract) and moderate TAC (19.96 ± 0.9 mg GE/g extract), respectively. In AOX, highest DPPH (50.52 ± 0.03 mg AAE/g extract) and ABTS (26.78 ± 0.03 mg TE/g extract) radical scavenging reported in methanolic extract of fruit; however, acetone extract of leaf showed highest FRAP (376.89 ± 1.95 mg Fe(II)/g extract) and PMA (326.54 ± 4.73 mg AAE/g extract). In contrast, aqueous extract of leaf and fruit revealed highest metal chelating activity (41.67 ± 0.49 mg EDTA/g extract). In anti-diabetic studies, acetonitrile extract of leaves and fruits exhibited appreciable inhibition of α-amylase (83.33%) and α-glycosidase (77.42%) enzymes. Similarly, acetyl cholinesterase (AChE) inhibition was highest in water (88.91%) and acetone (81.87%) extracts of leaf and fruits. Fruit extracts showed potent anticancer activity against breast (MCF-7) and colon (HT-29) cancer cell lines (LC50 329.36 and 385.17 µg/mL, respectively). RP-HPLC analysis revealed highest cucurbitacin B (CuB) (196.24 ± 1.4 mg/g DW), followed by cucurbitacin I (CuI) and cucurbitacin E (CuE) in the fruits (57.14 ± 4.9 and 2.03 ± 0.03 mg/g DW, respectively). RP-HPLC analysis of extracts revealed presence of gallic acid (GA), catechin (CA), vanillic acid (VA), chlorogenic acid (CHLA) and coumaric acid (COA), in which highest GA found in the fruits (1.26 ± 0.07 mg/g DW). Liquid chromatography and mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) analysis revealed presence of bioactive compounds from various groups. Based on the present findings, it was revealed that the fruit and leaf of L. echinata can be used as potent bioresource for natural antioxidants, anti-diabetic, and anticancer drug.

ABTS

Tannin

10.1016/j.sjbs.2021.03.050

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Phytochemicals and Bioactivities of Devil's Claw: Martynia Annua L. (Family: Martyniaceae)

Apple Academic Press eBooks (2023)

Rahul L. Zanan Suraj B. Patel Shreedhar S. Otari Savaliram G. Ghane

Claw

10.1201/9781003284468-12

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Trichosanthes Kirilowii Maxim.: A Pharmacologically Most Active Snake Gourd

Apple Academic Press eBooks (2023)

Suraj B. Patel Shreedhar S. Otari Rahul L. Zanan Savaliram G. Ghane

Maxim

Trichosanthes

10.1201/9781003284444_27

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Phytoconstituents and Pharmacology of Leucas Aspera L.: An Important Aromatic Weed

Apple Academic Press eBooks (2023)

Shreedhar S. Otari Suraj B. Patel Savaliram G. Ghane

Leucas aspera L. belongs to family Lamiaceae. It is a common aromatic herb found in India. It is branched, annual herb with a height of 15–60 cm with erect, stout and quadrangular stems. In several traditional medicines, it is used to treat cough, cold, painful swellings, wound, and skin disorders. It is also useful to treat the snake bite. Active compounds found in various plant parts showed significant medicinal potential. Variety of phytoconstituents such as triterpenoids, phenolics, flavonoids, glycosides, alkaloids, steroids, cardiac glycosides and diterpenes have been reported from the plant. Seed oil contains several fatty acids such as palmitic acid, stearic acid, oleic acid, linoleic acid, and linolenic acid. L. aspera possesses several potent biological activities like antioxidant, antibacterial, cytotoxic, larvicidal, antifungal, anticancer, anti-inflammatory etc.

Leucas

10.1201/9781003346142-7

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Bioactive potential and RP-HPLC detection of phenolics and alkaloids (lycorine and galanthamine) from ultrasonic-assisted extracts of Crinum roots

South African Journal of Botany (2021)

Manoj M. Lekhak Suraj B. Patel Shreedhar S. Otari U.M. Lekhak Savaliram G. Ghane

In this study, ultrasonic-assisted root extracts (methanolic and aqueous) of 16 Crinum genotypes were investigated for their antioxidants, phytochemicals and alkaloids (lycorine and galanthamine). The maximum TPC was recorded in methanolic extract of CAF1 (10.871 ± 0.2 mg TAE/g DW) and the least in CA (5.291 ± 0.1 mg TAE/g DW). TFC ranged from 0.446 ± 0.03 (CA) to 1.051 ± 0.07 mg CE/g DW (CMOR) for methanolic extracts whereas for aqueous extracts the range was 0.258 ± 0.01 (CAF2) to 1.312 ± 0.05 mg CE/g DW (COME). TTC values were recorded higher from aqueous extracts whereas TAC was on the higher side in methanolic extracts. TTC was the highest in COME (6.960 ± 0.16 mg CE/g DW) and TAC in CMOR (2.510 ± 0.21 mg BE/g DW). The highest DPPH and ABTS radical scavenging were noted in CMOR (1.886 ± 0.07 mg AAE/g DW) and CP (18.251 ± 1.32 mg TE/g DW), respectively. Similarly, the highest FRAP and PMA activities were found from methanolic extracts of CAF1 (6.751 ± 0.06 mg Fe(II)E/g DW) and CAF2 (6.093 ± 0.16 mg AAE/g DW). Water extract of CM (4.788 ± 0.03 mg EDTA/g DW) had the highest metal chelation potential. Maximum inhibition of α-amylase and α-glucosidase was noticed in the methanolic extracts of CV (43.51%) and CM (85.58%), respectively. Similarly, the maximum inhibition (95.99%) of acetylcholinesterase activity was noted in the methanolic extract of CA. RP-HPLC revealed that GA and COA were the most common phenolics in the roots. The alkaloid, lycorine was detected in all the genotypes and galanthamine in only 14 genotypes. The highest lycorine content was detected in CW (6.28 ± 0.54 mg/g DW) and the lowest in CXA (0.45 ± 0.01 mg/g DW). Galanthamine content ranged from 0.10 ± 0.00 μg/g DW (CP) to 348.98 ± 0.01 μg/g DW (CXA). Ultrasonic-assisted extraction can be one of the sustainable approaches for the enhanced recovery of phytochemicals from Crinum species. Present study inferred that Crinum is a magnificent source of antioxidants, natural inhibitors of α-glucosidase as well as anti-Alzheimer and anticancer drugs.

Lycorine

ABTS

Phytochemical

10.1016/j.sajb.2021.07.024

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Citations (15)