Gao Shang-pu

Shanghai University of Traditional Chinese Medicine

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Xin Zhou

Yale University

Tang Han-jun

Kindai University

Xueqing Wu

Xuzhou Medical College

Weisong Kong

Yunnan Academy of Forestry

Molly Kulesz‐Martin

Oregon Health & Science University

Hongfeng Chen

South China Botanical Garden

XU Jie-nan

Longhua Hospital Shanghai University of Traditional Chinese Medicine

Huafa Que

Shanghai University of Traditional Chinese Medicine

LU De-ming

Gaozhou People's Hospital

James Lagowski

Oregon Health & Science University

Cooperative Institutions

Shanghai University of Traditional Chinese Medicine

Longhua Hospital Shanghai University of Traditional Chinese Medicine

Oregon Health & Science University

Shanghai University

Oregon Medical Research Center

Yale University

Northeastern University

Wuxi Municipal Product Quality Supervision and Inspection Institute

Soochow University

First Affiliated Hospital of Soochow University

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Clinical significance of total serum IgE level and peripheral blood eosinophil count in children's atopic dermatitis

Medical Journal of Chinese People's Health (2010)

Gao Shang-pu

Objective:To investigate the clinical significance of level of total serum IgE and peripheral blood Eosinophil count(EOS) in children with atopic dermatitis(AD).Methods: Determination of total serum IgE levels and peripheral blood EOS of light,moderate and severe AD children patients and healthy children of the same age group(45 cases of AD and 45 cases of healthy children as control) in our hospital.Results: ① Total serum IgE level of children with AD was(1026.73±379.25)kU/L,drastically higher than the IgE level of control group(11.47±2.11)kU/L(P0.05);among light,moderate and severe AD patient children,total serum IgE levels were not significantly different(P0.05).②Peripheral blood EOS count was(623.33±309.11)×106/L in children with AD,significantly higher(P0.05) then control children group;EOS count in mild AD children and normal children were significantly different(P0.05);in children with severe AD,EOS count was dramatically higher than that of children with moderate AD(P0.05).Conclusion: Total Serum IgE level and peripheral blood Eosinophil count(EOS) are important parameters in diagnosis of Atopic dermatitis.

Clinical Significance

Complete blood count

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Effects of Curcumin on the Expression of Nuclear Factor(NF)-κB and its Iinhibitor IκBα in Mice Keratinocytes

The Chinese Journal of Dermatovenereology (2011)

Gao Shang-pu

Objective To observe the effects of curcumin on the proliferation and expression of nuclear factor(NF)-κB and its inhibitor IκBα in mice keratinocytes 291.Methods Cultured 291 cells up to 90% confluence and then treated them with 5,10,15,20,25μmol/L curcumin for 3h and 6h respectively,then optical density(OD) was measured in every group.Cultured 291 cells up to 90% confluence,added tumor necrosis factor α(TNF-α)(20ng/mL)and/or curcumin(20μmol/L) in every well respectively and incubated for 3 hours.Cell morphological changes were observed by microscopy and cell viability was measured by using MTT assay,the expression of NF-κB and IκBα protein were detected by Western blot.Results MTT showed that the 291 cell proliferation was down regulated by curcumin significantly in a does and time dependent manner;after treated by TNF-α(20ng/mL)and/or curcumin(20μmol) for 3 hours,the 291 cells in curcumin group were contracted,turned round and there were more dead cells than that in other groups.As assessed by MTT assay,curcumin could inhibite the proliferation of 291 cells(P0.05).Western blot analysis revealed in curcumin group NF-κB protein decreased,IκBα protein significant increased(P0.05);but in TNFα group NF-κB protein was increased(P0.05).Conclusion Curcumin inhibits the proliferation of 291 cells significantly.The mechanism may be related with curcumin down regulating NF-κB but up regulating IκBα.

MTT assay

Viability assay

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Qingdai ointment in the treatment of plaque psoriasis: a case report

Longhua Chinese Medicine (2019)

Gao Shang-pu Weisong Kong Xin Zhou

Abstract: Plaque psoriasis is a severe and refractory skin disease of psoriasis vulgaris, which lacks an ideal therapeutic method at present. Recently Qingdai ointment, an in-hospital preparation, was used alone to treat a case of plaque psoriasis, and the curative effect was excellent.

10.21037/lcm.2019.09.03

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Treatment of 56 cases of post-adolescent acne by "Yangyin Qingfei Decoction"

Shanghai Journal of Traditional Chinese Medicine (2011)

Gao Shang-pu

Objective To observe the clinical efficacy of Yangyin Qingfei Decoction in the treatment of post-adolescent acne.Methods One hundred and nine cases of post-adolescent acne were randomized into two groups: treatment group in which 56 cases were treated with Yangyin Qingfei Decoction and Cuochuang Lotion,and contro1 group in which 53 cases were treated with Tanshinone Capsule and Cuochuang Lotion,with a course of 8 weeks.Results The marked effective rate was 82.14% in the treatment group and 69.18% in the control group;with a significant difference between them(P0.05).In the treatment group the cure rate and the total effective rate for moderate post-adolescent acne were 75.00% and 90.00% respectively,higher than 56.41% and 74.36% in the control group,with striking differences between the two groups(P0.05).Conclusion Yangyin Qingfei Decoction is quite effective for post-adolescent acne.

Decoction

Lotion

Capsule

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Experimental Study on External Application of Leaf Frost in Treating Skin Lesion of Psoriasis

Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai (2003)

Gao Shang-pu

To explore the effects of external application of leaf frost on microstructure of affected skin of psoriasis,the leaf frost was applied on the tails of mice for 18 days to observe the changes of local epidermal granular cell counts.Results:The counts of granular cells were obviously higher in the observation group than in control group,suggesting that the leaf frost can improve the skin lesion.

Frost (temperature)

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Regulation of the Psoriatic Chemokine CCL20 by E3 Ligases Trim32 and Piasy in Keratinocytes

Journal of Investigative Dermatology (2010)

Yuangang Liu James Lagowski Gao Shang-pu James H. Raymond Clifton R. White

CCL20

Proinflammatory cytokine

10.1038/jid.2009.416

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Effects of Huoxue Bushen Mixture on skin blood vessel neogenesis and vascular endothelial growth factor expression in hair follicle of C57BL/6 mice

Journal of Chinese Integrative Medicine (2007)

Gao Shang-pu

Neogenesis

10.3736/jcim20070214

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Effect of Runing II on the Growth and Metastasis of Transplanted Tumor in Mammary Cancer-bearing Mice and Its Mechanism

Deleted Journal (2008)

Huafa Que Hongfeng Chen Gao Shang-pu LU De-ming Tang Han-jun

To study the effect of Runing II (a Chinese herbal preparation for mammary cancer) on the growth and metastasis of transplanted tumor of mammary cancer MA-891-bearing TA2 mice and its mechanism. The model of mammary cancer MA-891 cell strain transplanted tumor of TA2 mice with lung metastasis were developed to observe the effect of Runing II on the growth and metastasis of the transplanted tumor. The immunohistochemical method and image analysis were adopted to detect the levels of vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor (VEGFR), and micro-vessel count (MVC) and micro-vessel area (MVA). In the Runing II group, the tumor weight inhibition rate and the lung metastasis inhibition rate were 37.3% and 65.4% respectively, the tumor growth and lung metastasis were obviously inhibited; And the levels of VEGF and VEGFR, MVC and MVA were significantly decreased as compared with those in the tumor-bearing control group (P<0.05). The Chinese herbal preparation Running II can inhibit the metastasis of tumor through inhibiting the angiogenesis, and the mechanism is possibly related with down-regulation of VEGF and VEGFR expression.

Mammary tumor

10.1016/s0254-6272(09)60015-7

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[Effect of Runing II on expression of vascular endothelial growth factor in transplanted tumor of mammary cancer MA-891 in TA2 mice].

PubMed (2004)

Xueqing Wu Gao Shang-pu Mingchun Mu

To study the effect of Runing II on expression of vascular endothelial growth factor (VEGF) in transplanted tumor of mammary cancer MA-891 in TA2 mice.The MA-981 mice mammary cancer cell cultivated in vivo was inoculated into the right axilla subcutaneously of TA2 mice to establish the transplanted tumor model, which were treated with Runing II.Runing II could inhibit the growth of transplanted tumor and the occurrence of lung metastasis (P < 0.05), reduce the expression of VEGF protein and mRNA in tumor tissue (P < 0.05).Runing II could reduce the expression of VEGF protein and mRNA, hence to inhibit the growth of tumor and lung metastasis.

Mammary tumor

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