Hussien Rizk

Cairo University

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Co-Authors

Nuria Fernández‐Hidalgo

Instituto de Salud Carlos III

Jacob Strahilevitz

Hadassah Medical Center

Marwa Sayed Meshaal

Cairo University

Francisco Nacinovich

Instituto Cardiovascular de Buenos Aires

Vladimir Krajinović

University Hospital for Infectious Diseases "Dr Fran Mihaljevic"

Bruno Baršić

University of Zagreb

Cristian Mornoş

Victor Babeș University of Medicine and Pharmacy Timișoara

Sarah Israel

Hadassah Medical Center

John L. Klein

Guy's and St Thomas' NHS Foundation Trust

Pierre Tattevin

Inserm

Cooperative Institutions

Association Française pour le Dépistage et la Prévention des Handicaps de l’Enfant

339

University of Liège

337

Shaheed Rajaei Cardiovascular Medical and Research Center

290

Associazione Nazionale Medici Cardiologi Ospedalieri

278

Institut de Recherche pour le Développement

237

Méditerranée Infection Foundation

230

Maria Cecilia Hospital

224

Inserm

169

European Society of Cardiology

144

Erasmus MC

143

Author Statistics

Papers

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Gender differences in clinical features and complications of infective endocarditis: 11-year experience of a single institute in Egypt

The Egyptian Heart Journal (2020)

Ahmed A. Elamragy Marwa Sayed Meshaal Amani El‐Kholy Hussien Rizk

Abstract Background No data exists about the gender differences among patients with infective endocarditis (IE) in Egypt. The objective was to study possible gender differences in clinical profiles and outcomes of patients in the IE registry of a tertiary care center over 11 years. Results The IE registry included 398 patients with a median age of 30 years (interquartile range, 15 years); 61.1% were males. Males were significantly older than females. Malignancy and recent culprit procedures were more common in females while chronic liver disease and intravenous drug abuse (IVDU) were more in males. IE on top of structurally normal hearts was significantly more in males (25.6% vs 13.6%, p = 0.005) while rheumatic valvular disease was more common in females (46.3% vs 29.9%, p = 0.001). There was no difference in the duration of illness before presentation to our institution. The overall complication rate was high but significantly higher in females. However, there were no significant differences in the major complications: mortality, fulminant sepsis, renal failure requiring dialysis, heart failure class III–IV, or major cerebrovascular emboli. Conclusion In this registry, IE occurred predominantly in males. Females were significantly younger at presentation. History of recent culprit procedures was more common in females while IVDU was more common in males who had a higher incidence of IE on structurally normal hearts. The overall complication rate was higher in women. IE management and its outcomes were similar in both genders.

Culprit

Interquartile range

Infective Endocarditis

10.1186/s43044-020-0039-6

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Citations (16)

Poster session IV * Friday 10 December 2010, 14:00-18:00

European Journal of Echocardiography (2010)

Alessandro De Angelis Eva Base W Schmid Martin Andreas U. Weber

10.1093/ejechocard/jeq146

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389 Experience in a specialized heart failure unit in a tertiary care hospital in Egypt: demographic characteristics and in-hospital outcome of patients with severe heart failure

European Journal of Heart Failure Supplements (2003)

Magdy Abdelhamid Karim Said Hussien Rizk

Tertiary care

Tertiary level

10.1016/s1567-4215(03)90244-x

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First Report of Zoonotic Endocarditis in Egypt: High Prevalence of Brucella in Culture-Negative Endocarditis

International Journal of Infectious Diseases (2012)

M Enany Hussien Rizk Amani El‐Kholy E. Abdul Rahman Hussein Heshmat

Background: Background:Zoonotic agents, such asCoxiella burnetii,Brucellaspp., andBartonellaspp.were frequently detected in North Africa and identified as frequent causes of infective endocarditis (IE) in some countries. In Egypt, 50% of the patients diagnosed as definite IE are blood culture negative and the medical institutes in Egypt do not include zoonotic agents laboratory diagnosis in the IE workup. Objective: To study the contribution ofBrucella spp., Bartonella spp.andCoxiella burnetiiin IE in Egypt and to study the application of laboratory detection methods for these agents as a routine in the IE workup. Methods: Methods:A prospective study on patients with suspected IE referred to the Cardiology Department of Cairo University from February 2005 to February 2009. Three sets of blood culture were withdrawn on admission. Resected valves were cultured. Sera of patients were tested forBrucellaantibodies using standard agglutination test. IFA test for IgG forBartonella,and IgG, IgM, and IgA forCoxiella burnetiiwas done. PCR was performed on blood of patients with positive serology forBrucella,andon 33 cardiac valves forBartonella. Results: Results:150 patients were diagnosed as definite IE; 50% of them had BCNE. By serology, zoonotic pathogens were identified in 11 of all IE patients;Brucellain 5,Bartonellain 5 andCoxiella burnetiiin 1. PCR forBrucellawas positive for the 5 patients and for one patient withBartonellapositive serology. After the completion of the research, the detection of zoonotic agents was applied as a routine in the IE workup for the first time in Egypt and this approach was also disseminated to other institutes through different educational activities and laboratory cooperation. Conclusion: Conclusion:The study showed a higher proportion of IE due toBrucellathan any other reported in North Africa. The quality of IE patients management in Egypt was improved after completion the this work.

Blood Culture

Bartonella

Direct agglutination test

Infective Endocarditis

Rapid diagnostic test

10.1016/j.ijid.2012.05.523

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THE TIMING OF CHOLEDOCHOLITHOTOMY AND THE TYPE OF BILIARY DRAINAGE AFTER FAILEDENDOSCOPIC RETROGRADE CHOLANGIO PANCREATOGRAPHY (ERCP) IN CALCULAR OBSTRUCTIVE JAUNDICE.

The Egyptian Journal of Surgery (2002)

A. H. I. Helmy Mohammed Abbas Y. F . Youssef Hussien Rizk H. El-Khyat

Obstructive jaundice

Biliary Drainage

10.21608/ejsur.2002.375150

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385 Value of the filtered QRS duration in patients with rheumatic mitral and or aortic regurgitation and dilated left ventricle

European Journal of Heart Failure Supplements (2004)

M A Abdelhamid S. El Bardisy H. Elhossary Hussien Rizk

10.1016/s1567-4215(04)90294-9

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P45 FUNGAL ENDOCARDITIS: EARLY DIAGNOSIS AIMING AT BETTER OUTCOME AND PREDICTORS OF MORTALITY

International Journal of Antimicrobial Agents (2013)

Marwa Sayed Meshaal Khaled Mohamed Said Mohamed Hosny W.A. Arousy S. Elaziz

10.1016/s0924-8579(13)70069-4

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Beta-Hemolytic Streptococcal Infective Endocarditis: Characteristics and Outcomes From a Large, Multinational Cohort

Open Forum Infectious Diseases (2020)

Nuria Fernández‐Hidalgo Amal Gharamti María Luisa Aznar Benito Almirante Mohamad Yasmin

Abstract Background Beta-hemolytic streptococci (BHS) are an uncommon cause of infective endocarditis (IE). The aim of this study was to describe the clinical features and outcomes of patients with BHS IE in a large multinational cohort and compare them with patients with viridans streptococcal IE. Methods The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) is a large multinational database that recruited patients with IE prospectively using a standardized data set. Sixty-four sites in 28 countries reported patients prospectively using a standard case report form developed by ICE collaborators. Results Among 1336 definite cases of streptococcal IE, 823 were caused by VGS and 147 by BHS. Patients with BHS IE had a lower prevalence of native valve (P < .005) and congenital heart disease predisposition (P = .002), but higher prevalence of implantable cardiac device predisposition (P < .005). Clinically, they were more likely to present acutely (P < .005) and with fever (P = .024). BHS IE was more likely to be complicated by stroke and other systemic emboli (P < .005). The overall in-hospital mortality of BHS IE was significantly higher than that of VGS IE (P = .001). In univariate analysis, variables associated with in-hospital mortality for BHS IE were age (odds ratio [OR], 1.044; P = .004), prosthetic valve IE (OR, 3.029; P = .022), congestive heart failure (OR, 2.513; P = .034), and stroke (OR, 3.198; P = .009). Conclusions BHS IE is characterized by an acute presentation and higher rate of stroke, systemic emboli, and in-hospital mortality than VGS IE. Implantable cardiac devices as a predisposing factor were more often found in BHS IE compared with VGS IE.

Infective Endocarditis

Stroke

Univariate analysis

10.1093/ofid/ofaa120

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Citations (18)

Evaluation of broad-range 16S rRNA PCR for the diagnosis of bloodstream infections: two years of experience

The Journal of Infection in Developing Countries (2014)

Reem Hassan M Enany Hussien Rizk

Diagnosis of bloodstream infections using bacteriological cultures suffers from low sensitivity and reporting delay. Advanced molecular techniques introduced in many laboratories provide rapid results and may show improvements in patient outcomes. This study aimed to evaluate the usefulness of a molecular technique, broad-range 16S rRNA PCR followed by sequencing for the diagnosis of bloodstream infections, compared to blood culture in different patient groups.Conventional PCR was performed, using broad-range 16S rRNA primers, on blood cultures collected from different patients with suspected bloodstream infections; results were compared with those of blood culture.Though blood culture is regarded as the gold standard, PCR evaluation showed sensitivity of 86.25%, specificity of 91.25%, positive predictive value of 76.67%, negative predictive value of 95.22%, and accuracy of 88.8%.Molecular assays seem not to be sufficient to replace microbial cultures in the diagnosis of bloodstream infections, but they can offer a rapid, good negative test to rule out infection due to their high negative predictive value.

Gold standard (test)

Blood Culture

Bloodstream infection

Bacteremia

Microbiological culture

10.3855/jidc.4867

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Citations (16)

Correction to: Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry

Infection (2022)

Michal Pazderník Bernard Iung Bülent Mutlu François Alla Robert K. Riezebos

Infective Endocarditis

10.1007/s15010-022-01883-y

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