X-ray microanalysis of Michaelis--Gutmann bodies in human malakoplakia (kidney and testes) and in that of rats induced experimentally by administration of endotoxin of Escherichia coli, was carried out. The presence of calcium could be revealed in every Michaelis--Gutmann body according to the lines of Kalfa and K3 as well. The amount of it was in correlation with the stage of the calcification. In the Michaelis--Gutmann bodies found in the rat kidney, fixed without OsO4 presence of P could also be demonstrated. The correlation between the weight per cent of Ca and P seems to evidence the presence of CaHPO4. Results of the X-ray microanalysis of Michaelis--Gutmann bodies found in human and in experimentally induced malakoplakia appeared to be similar.
The correlation of B mode and Doppler sonographic parameters and diagnoses established by histological examination of graft biopsies, nephrectomies and clinical data are discussed. 48 histological samples from 36 patients were reevaluated. The maximum interval between sonography and histology was 36 hours. The Banff classification criteria were used during histological examinations. Doppler examination evaluation was based on the resistance index (RI). Reproducibility was controlled by means of intra- and interobserver variability in 10 patients. RI values higher than 75% were regarded as abnormal. On the basis of these observations and the literature data specific sonographic features can be detected in renal artery occlusion and renal vein thrombosis. In pyelonephritis, dilatation of the collecting system was frequent. No morphological changes were detected in cyclosporin-A nephrotoxicity and the Doppler signs were not characteristic for this disease. No differentiation was found between acute rejection and acute tubular necrosis. The noninvasive duplex sonographic examinations can provide very important information regarding the flow situation of a transplanted kidney. In some cases a definitive diagnosis can be achieved, but in other cases biopsy is the method of choice.
13 cases of renal amyloidosis were reclassified on the basis of the chemical types of the major amyloid fibril proteins. The classification (primary, secondary) depending on the absence or presence of a coexisting disease was found not to correlate with the classification based on the chemical types (AL, AA). It is concluded that in association with a disease capable of inducing amyloidosis amyloid of type AA does not necessarily appear. The deposited amyloid may be of AL type. No difference of decisive importance between the AL and the AA type was observed concerning the tissue distribution of the amyloid within the kidney. With respect to the cause of death, however, a significant difference was found between the chemical types. In amyloidosis of AA type, the cause of death was always renal insufficiency, whereas in the cases of AL type cardiac or hepatic insufficiency led to death. Differentiation of the types of amyloid proteins has gained practical importance, as it offers the possibility of selective therapeutic approaches. Their routine differentiation is possible with the potassium permanganate method.
Journal Article Two Cases of Recurrent Focal and Segmental Glomerulosclerosis in Renal Allografts Get access T. Nádasdy, T. Nádasdy Departments of Pathology, Surgery, Paediatrics, and Medicine, Albert Szent-Györgyi Medical UniversitySzeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Iványi, B. Iványi Departments of Pathology, Surgery, Paediatrics, and Medicine, Albert Szent-Györgyi Medical UniversitySzeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Marofka, F. Marofka Departments of Pathology, Surgery, Paediatrics, and Medicine, Albert Szent-Györgyi Medical UniversitySzeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Orvos, H. Orvos Departments of Pathology, Surgery, Paediatrics, and Medicine, Albert Szent-Györgyi Medical UniversitySzeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Mohácsi, G. Mohácsi Departments of Pathology, Surgery, Paediatrics, and Medicine, Albert Szent-Györgyi Medical UniversitySzeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Ormos J. Ormos Departments of Pathology, Surgery, Paediatrics, and Medicine, Albert Szent-Györgyi Medical UniversitySzeged, Hungary Search for other works by this author on: Oxford Academic PubMed Google Scholar Nephrology Dialysis Transplantation, Volume 6, Issue 5, 1991, Pages 375–376, https://doi.org/10.1093/ndt/6.5.375 Published: 01 January 1991
Background: Necrolytic migratory erythema is considered to be a paraneoplastic dermatosis. The classical symptoms are associated with α‐cell pancreatic islet cell tumor or ‘glucagonoma’. Generally, extracutaneous hallmarks of this disease include weight loss, diabetes, anaemia and diarrhoea. Observation: We report a case of a 39‐year‐old woman with a 3‐year history of recalcitrant psoriasiform eruption, who had no other associated symptoms on routine examination. Histologic examinations suggested necrolytic migratory erythema. Abdominal computer tomography was performed, which revealed a tumor in the tail of the pancreas. After distal resection of the pancreas her skin symptoms resolved in a few days time. Histology was consistent with glucagonoma. She is clinically well and symptomless and no signs of metastasis after 4 years. Conclusions: It is infrequent to have only necrolytic migratory erythema, hyperglucagonaemia and islet‐cell tumor but no other extracutaneous symptoms in glucagonoma syndrome. To our knowledge, ours is the second such case reported in the literature. Skin symptoms are important, often they are the clue to the diagnosis of glucagonoma syndrome.
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