Introduction: Severe gagging in some patients during dental procedures can complicate the procedure. In this study, the effect of oral ondansetron and placebo, as antiemetic medications, on gag reflex was evaluated with the stimulation of soft palate and palatine tonsil areas to simulate the clinical situation during dental procedures. Materials and methods: In this clinical trial, 88 healthy adult individuals were randomly divided into two equal groups of ondansetron and placebo, which were administered orally. Gag reflexes were checked using a tongue depressor and recorded before and 90 minutes after intervention in the soft palate and palatine tonsil areas. Data was analyzed and compared with SPSS software, using Mann-Whitney and Wilcoxon tests (α = 0.05). Results: In the ondansetron group a statistically significant decrease in gag reflex was noted after intervention in both soft palate and tonsil areas (p value < 0.05); however, no significant decrease was observed in the placebo group in the two areas after intervention. Conclusion: The results of the present study showed the efficacy of ondansetron in reducing the severity of gag reflex in both the soft palate and tonsil areas; therefore, its administration can be considered in clinical procedures in those areas. Key words: Dentistry, Gag reflex, Ondansetron.
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