Advanced ScienceVolume 12, Issue 6 2570032 Inside Back CoverOpen Access A Novel "Three-in-One" Copper-Based Metal-Organic Framework Nanozyme Eradicates Colorectal Cancer and Overcomes Chemoresistance for Tumor Therapy (Adv. Sci. 6/2025) Shuohui Dong, Shuohui DongSearch for more papers by this authorHaolin Cao, Haolin CaoSearch for more papers by this authorYe Yuan, Ye YuanSearch for more papers by this authorShuo Liang, Shuo LiangSearch for more papers by this authorZhendong Fu, Zhendong FuSearch for more papers by this authorWei Shi, Wei ShiSearch for more papers by this authorQian Xu, Qian XuSearch for more papers by this authorXiang Zhao, Xiang ZhaoSearch for more papers by this authorJingnan Shi, Jingnan ShiSearch for more papers by this authorXiaoxiao Guo, Xiaoxiao GuoSearch for more papers by this authorKaili Guo, Kaili GuoSearch for more papers by this authorSanyuan Hu, Sanyuan HuSearch for more papers by this authorGuangyong Zhang, Guangyong ZhangSearch for more papers by this authorLizeng Gao, Lizeng GaoSearch for more papers by this authorLei Chen, Lei ChenSearch for more papers by this author Shuohui Dong, Shuohui DongSearch for more papers by this authorHaolin Cao, Haolin CaoSearch for more papers by this authorYe Yuan, Ye YuanSearch for more papers by this authorShuo Liang, Shuo LiangSearch for more papers by this authorZhendong Fu, Zhendong FuSearch for more papers by this authorWei Shi, Wei ShiSearch for more papers by this authorQian Xu, Qian XuSearch for more papers by this authorXiang Zhao, Xiang ZhaoSearch for more papers by this authorJingnan Shi, Jingnan ShiSearch for more papers by this authorXiaoxiao Guo, Xiaoxiao GuoSearch for more papers by this authorKaili Guo, Kaili GuoSearch for more papers by this authorSanyuan Hu, Sanyuan HuSearch for more papers by this authorGuangyong Zhang, Guangyong ZhangSearch for more papers by this authorLizeng Gao, Lizeng GaoSearch for more papers by this authorLei Chen, Lei ChenSearch for more papers by this author First published: 10 February 2025 https://doi.org/10.1002/advs.202570032AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookxLinkedInRedditWechat Graphical Abstract "Three-in-One" Nanozyme for Tumor Therapy This cover illustration depicts three angels supporting a net that captures tumor cells. In article number 2413422 by Lei Chen, Shuohui Dong, and co-workers, a "Three-in-One" Cu-based metalorganic framework nanozyme is developed, aiming to eradicate colorectal cancer and overcome chemoresistance through apoptosis, cuproptosis, and facilitating the degradation of hypoxia-inducible factor-1a. Volume12, Issue6February 10, 20252570032 RelatedInformation
Exosomes (Exos) are endogenous nanocarriers that have utility as novel delivery systems for the treatment of brain cancers. However, in general, natural Exos show limited BBB-crossing capacity and lack specific targeting. Further modifications including targeting peptides and genetic engineering approaches can circumvent these issues, but the process is time-consuming. Focused ultrasound (FUS) has been approved by the Food and Drug Administration for the diagnosis and treatment of brain diseases due to its noninvasive nature, reversibility, and instantaneous local opening of the BBB. In this study, we developed a natural and safe transportation system using FUS to increase the targeted delivery of Exos for glioma therapy. We also compared the advantages of macrophage-derived Exos (R-Exos) and blood serum-derived Exos (B-Exos) to screen for an improved platform with scope for clinical transformation. In vitro, both R-Exos and B-Exos were transported through BBB models and accumulated in glioma cells with the assistance of ultrasound exposure. R-Exos and B-Exos displayed no obvious differences in physical characteristics, drug release, tumor targeting, and cytotoxicity when combined with FUS. In vivo animal imaging studies suggested that the fluorescence intensity of B-Exos plus single FUS in brains was 4.45-fold higher than that of B-Exos alone. Furthermore, B-Exos plus twice FUS treatment efficiently suppressed glioma growth with no obvious side effects. We therefore demonstrate that the combination of FUS and naturally abundant B-Exos is a potent strategy for brain cancer therapeutics.
Abstract Paradoxical leadership is an emerging leadership style which describes leadership behaviours that are ostensibly contradictory but in reality are interrelated and address workplace demands simultaneously and over time. The present study is based on affective events theory (AET), which states that occurrences or events at work result in prompt positive or negative affect in employees. The purpose of the study is to examine the mediating role of positive affect on the relationship between paradoxical leadership and employee organizational citizenship behaviour (OCB). We also examine the moderating role of procedural fairness on the relationship between employee positive affect and OCB. Data collected in two phases in small- and medium-sized Chinese companies indicate that positive affect fully mediates the relationship between paradoxical leadership and employee OCB, and this relationship was found to be stronger when procedural fairness was higher rather than lower. We provide theoretical and practical implications of these findings.
In 5G ultra dense heterogeneous network, the scheme of Passive Reception Detection (PRD) can exploit more busy bands and enhance the small base station (SBS) access opportunity by identifying the distance between the active macro vehicle (MVE) and the macro base station (MBS). In this paper, with the assistance of the MBS, the MVE distribution area can be obtained by the SBS joint-PRD scheme. And the probability density function of the distance between the MVE and SBS is derived leveraging stochastic geometry. By combining the trajectory prediction of co-channel MVE location with levy flight mobile model, the opportunity of the SBS accessing the busy bands can be derived. It is useful to maximize the number of concurrent vehicle-to-vehicle transmissions. The simulation results show that by taking advantage of the proposed scheme in the mobile network, the overall system throughput can be improved more than 20% regardless of the co-channel MVE velocity.
State Grid E-learning is an online training service platform for the unified construction and promotion and application of the State Grid Corporation of China.This paper carries out research on personalized recommendation technology of courseware resources of the State Grid School, adopts hybrid Collaborative filtering algorithm and Knowledge graph classification system, establishes an intelligent recommendation system based on user's stereoscopic portrait on the State Grid School, connects user attributes and behaviors with the digital training resources of the State Grid School, greatly improves the efficiency of resource utilization in various application scenarios, and realizes intelligent push of resources at the same time, Enhance user learning experience.
The combating of multidrug resistance (MDR) plays a crucial role in effective chemotherapy. However, current strategies for cancer of MDR remain unsatisfactory for their limited efficacy and severe side effects. In this study, we sought to determine the anti-MDR effects of a traditional chinese herb, Hypocrellin B (HB)-mediated sonodynamic therapy (HB-SDT) on human gastric multidrug resistance cancer SGC-7901cell/ADR cells and its underlying mechanisms. HB-SDT can synergistically increase the cytotoxicity of DOX on SGC-7901cell/ADR cells in which the mechanism is related to significant promotion of apoptosis, ROS level and drop of MMP in the resistant cells after combining treatment of DOX and HB-SDT. Meanwhile, western blotting assays display the expression of apoptosis related proteins Bax and Bcl-2 changed markedly after the combination treatment. In addition, the expression of P-gp was significantly down-regulated after treatment of HB-SDT and DOX. HB-SDT can increase DOX-induced mitochondrial-dependent apoptosis by inhibiting the expression of P-gp, thereby increasing the cytotoxic effect into SGC7901/ADR cells.
Abstract Despite considerable advancements in the treatment of colorectal cancer (CRC), the overall survival rate for patients with advanced CRC remains below 50%, primarily due to challenges posed by drug resistance and metastasis. Here, a novel “Three‐in‐One” Cu‐based metal‐organic framework nanozyme with peroxidase‐like (POD‐like) activity has been successfully developed, aiming to promote CRC cell death by dual targeting of oxidative stress and copper ion homeostasis, which could promote CRC cell death via apoptosis and cuproptosis, and facilitate hypoxia‐inducible factor 1α (HIF‐1α) degradation, leading to the reversal of chemoresistance in tumor therapy. These nanozymes, composed of copper and 2‐propylimidazole (Cu‐PrIm), feature a distorted Cu‐N4 catalytic active center that mimics natural enzyme structures consisting of copper and histidine residues, endowing them with enzyme‐like activities. The antitumor efficacy of Cu‐PrIm nanozymes is validated in various in vivo models of CRC. Especially Cu‐PrIm nanozymes exhibit excellent biocompatibility, biodegradability, and a tolerable toxicity profile in mouse models, making them a strong candidate for clinical translation. Taken together, the study introduces a novel therapeutic paradigm in CRC treatment by targeting these vulnerabilities and leveraging the potential using “Three‐in‐One” Cu‐PrIm nanozymes to address multiple pathways simultaneously.
Blind source separation (BSS) is implemented for optical fiber sensing systems, such as the fiber Bragg grating (FBG) sensing system and the single-mode-multimode-single-mode fiber (SMS) sensing system. The FastICA, a kind of multichannel BSS algorithm, is used to get the strain and the temperature with two FBGs. For the SMS sensing, a single-channel blind source separation (SCBSS) algorithm is employed to simultaneously measure the vibration and the temperature variation with only one SMS sensor. The errors of both the FBG and the SMS optical fiber sensing system are very small with the BSS algorithm. The implementation of BSS for the optical fiber sensing makes the multiparameter measurements more easily with low cost and high accuracy and can also be applied for signal de-noising field.
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