Homayon Yousefi

Ahvaz Jundishapur University of Medical Sciences

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Mohammad‐Reza Mahmoudian‐Sani

Ahvaz Jundishapur University of Medical Sciences

Mohammad Javad Mohammadi

Kermanshah University of Medical Sciences

Najmaldin Saki

Ahvaz Jundishapur University of Medical Sciences

Kaveh Jaseb

Ahvaz Jundishapur University of Medical Sciences

Arash Alghasi

Ahvaz Jundishapur University of Medical Sciences

Bijan Keikhaei

Ahvaz Jundishapur University of Medical Sciences

Elena Lak

Ahvaz Jundishapur University of Medical Sciences

Daryush Purrahman

Ahvaz Jundishapur University of Medical Sciences

Ali Aminasnafi

Ahvaz Jundishapur University of Medical Sciences

Ali Shojaeian

Hamedan University of Medical Sciences

Cooperative Institutions

Ahvaz Jundishapur University of Medical Sciences

Tehran University of Medical Sciences

Isfahan University of Medical Sciences

University of Tehran

Shahrekord University of Medical Sciences

Shiraz University of Medical Sciences

Tarbiat Modares University

Shahid Beheshti University of Medical Sciences

Children's Medical Center

Hamedan University of Medical Sciences

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The effect of toxic air pollutants on fertility men and women, fetus and birth rate

Reviews on Environmental Health (2022)

Ria Margiana Homayon Yousefi Arghavan Afra Agustinus Agustinus Walid Kamal Abdelbasset

Abstract Human health is affected by various factors such as air pollutants. Exposure to toxic air pollutants is impaired fertility in men and women. The purpose of this review study was investigation of the effect of toxic air pollutants on fertility and birth rate. Databases used to for searched were the PubMed, Web of Science, Springer and Science Direct (Scopus) and Google Scholar. Identify all relevant studies published 1999–2022. In this study, according to databases five hundred articles were retrieved. 33 studies were screened after review and 19 full-text articles entered into the analysis process. Finally, 11 articles were selected in this study. The literature signs a notable health effects from toxic air pollutants and increase risk of infertility in men and women and having a variety of reproductive system cancers such as prostate, bladder, ovary, kidney and uterus. According to the finding toxic air pollutants can increase the risk infertility in men and women, incidence of cancers of reproductive system and decrease the birth rate. Activities that play an important role in reducing the health effects of toxic air pollutants such as infertility in men and women and reducing the population rate of communities are improving the quality of fuel used in the home, car, industries, changing production processes in large industries, installing catalysts to reduce emissions in cars, use more public transportation, plant trees and increase green space per capita, increase public awareness about various effects of toxic air pollutants and protective measures.

10.1515/reveh-2022-0032

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Homayon Yousefi Faramarz Zakavi Maria Cheraghi Hashem Mohamadian Alireza Karimi Malayer

Background and Objectives The present study examined the oral health-related quality of life in patients with thalassemia major in Khuzestan province. Subjects and Methods This was a descriptive analytical study. The case group included 120 patients suffering from thalassemia major disease who presented to Shafa Hospital in Ahvaz city in 2021, and the control group consisted of 120 healthy people who were either companions of the patients or their family members. The data collection tools were two standard questionnaires related to dry mouth and a questionnaire dedicated to oral heal-related quality of life. Results There was a significant difference between patients with beta-thalassemia major and healthy people in terms of their mean overall score of oral health-related quality of life and its dimensions (except for physical disability) (P<0.05). There was no significant difference between the two groups in terms of the mean score of physical disability (P>0.05). A significant difference was observed between the two groups in terms of the mean score of functional limitation in an age-dependent manner (P<0.05). Finally, the two groups were significantly different in terms of the mean score of physical disability as far as age and dry mouth were concerned (P<0.05). Conclusion According to the results obtained from the present study, appropriate psychological measures and strategies should be implemented to improve the oral health-related quality of life in patients with beta-thalassemia major.

Beta thalassemia

10.32592/jsmj.22.3.345

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Long non-coding RNA signatures and related signaling pathway in T-cell acute lymphoblastic leukemia

Clinical & Translational Oncology (2022)

Homayon Yousefi Daryush Purrahman Mohammad Jamshidi Elena Lak Bijan Keikhaei

10.1007/s12094-022-02886-9

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INTERLEUKIN-1 FAMILY AND INTERLEUKIN-6 GENE POLYMORPHISMS IN RECURRENT APHTHOUS STOMATITIS

Shamsoulmolouk Najafi E Firouzeh Moghadam Mohammad Mohammadzadeh Alireza Zare Bidoki Homayon Yousefi

Recurrent aphthous stomatitis

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Association of serum miR-375, miR-155 and miR-146b levels with distinguish of papillary thyroid cancer from benign thyroid masses among Iranian patients

Egyptian Journal of Medical Human Genetics (2023)

Gholam Reza Mobini Homayon Yousefi Ali Shojaeian Mahmood Mirhoseini Mohammad‐Reza Mahmoudian‐Sani

Abstract Background and aim Certain serum levels of microRNAs (miRNAs) throughout the body can be helpful for cancer diagnosis and prognosis. The miRNAs can be secreted from the papillary thyroid cancer (PTC) into the circulatory system. Accordingly, this study aimed to measure the serum levels of miR-146b, miR-155 and miR-375 to evaluate their diagnostic potentials in distinguish of benign from malignant lesions. Materials and methods The serum levels of miRNAs were measured by real-time quantitative RT-PCR among100 patients with benign thyroid nodules and 30 patients with PTC. Results The mean miR-375 and miR-155 expression levels in the PTC group were greater when compared with the benign group. The area under the ROC curve (AUC) was estimated at 0.81 for the miR-375 with 0.76% sensitivity and 0.80% specificity to distinguish between benign and PTC lesions. The AUC was calculated to be 0.75 for the miR-155 with 0.69% sensitivity and 0.90% specificity. Conclusion According to the results of this study, the serum levels of miR-155 and miR-375 were increased in the patients with PTC, which may be useful as alternative seromarkers for the PTC.

Thyroid Nodules

10.1186/s43042-023-00427-9

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Association Between Serum Ferritin Level and Gene Mutations in Patients with Thalassemia Major and Intermediate

Jundishapur Journal of Chronic Disease Care (2021)

Mohsen Anafje Kaveh Jaseb Homayon Yousefi

Background: Beta-thalassemia is one of the most important health problems worldwide. Identifying common mutations as well as the relationship between serum ferritin level and gene mutations in patients with intermediate and major thalassemia can be helpful in preventive programs. Objectives: The purpose of this study was to assess the association between serum ferritin level and gene mutations in patients with intermediate and major thalassemia. Methods: This descriptive cross-sectional study was done using patients' medical records available in the hospital archives, and data of 132 patients with mutated genes referred to Ahvaz Shafa hospital from 2012-2017 were evaluated. In addition to determining the frequency of different gene mutations, the relationship between different gene mutations and serum ferritin levels, as well as hemoglobin levels before the first blood transfusion and the age of the patients (month) before the first blood transfusion, were investigated. Results: There was no significant relationship between mutated genes and serum ferritin levels (P = 0.2). There was a significant difference between the types of gene mutations and the levels of hemoglobin before the first blood transfusion (P = 0.01). There was no significant difference between the types of gene mutations and the age of the patients before the first blood transfusion (P = 0.4). Conclusions: There was no association between the types of mutations and serum ferritin levels as an indicator of disease severity. Patients with hemoglobin levels of 6 to 7 mg/dl were found with a higher likelihood of receiving a blood transfusion, with a higher percentage having the IVSII-I gene mutation, but given that many mutations were random and we just had one or two patients with these mutations, it cannot be used as an indicator for disease severity. We need to conduct studies with a larger sample size to be used as an indicator for disease severity. Since the influence of the other accompanying genes and polymorphism plays an important role in the clinical manifestations of genetic diseases, it can be the reason for some negative results.

10.5812/jjcdc.110304

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The role of inflammatory mediators in the pathogenesis of periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA) syndrome

Molecular Biology Reports (2022)

Daryush Purrahman Łukasz A. Poniatowski Piotr Wojdasiewicz Fathi Mohammad Reza Homayon Yousefi

Etiology

Pathogenesis

Adenitis

10.1007/s11033-022-07352-x

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The effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors

Reviews on Environmental Health (2022)

Yousef Nikmanesh Mohammad Javad Mohammadi Homayon Yousefi Sara Mansourimoghadam Masoume Taherian

Abstract Toxic air pollutants are one of the most agent that have many acute, chronic and non-communicable diseases (NCDs) on human health under long or short-term exposure has been raised from the past to the present. The aim of this study was investigation effect of long-term exposure to toxic air pollutants on the increased risk of malignant brain tumors. Databases used to for searched were the PubMed, Web of Science, Springer and Science Direct (Scopus) and Google Scholar. 71 papers based on abstract and article text filtered. In the end after sieve we selected 7 papers. Identify all relevant studies published 1970–2022. The literature showed that exposure to toxic air pollutants and their respiration can cause disorders in different parts of the brain by transmission through the circulatory system and other mechanisms. Various unpleasant abnormalities are caused by the inhalation of toxic air pollutants in the human body that some of the most common of them include chronic lung disease, coronary heart disease and heart attacks, strokes and brain diseases (Parkinson’s, Alzheimer’s and multiple Sclerosis), cancers (liver, blood, prostate and brain) and eventually death. According to the finding brain health and proper functioning can be easily disrupted by various genetic or external factors such as air pollution, causing a wide range of abnormalities in the brain and malignant brain tumors. The results of this study showed that reducing the concentration of toxic pollutants in the air, that exposure to them play an increasing role in the development of brain diseases can slow down the process of abnormalities in the brain and will have significant impacts on reducing the number of people affected by them.

Inhalation exposure

Brain damage

10.1515/reveh-2022-0033

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Diagnosis and Management of Myelodysplastic Syndrome in a Fanconi Anemia Patient: A Case Report

Pediatric Hematology/Oncology and Immunopathology (2024)

Arash Alghasi Homayon Yousefi Reza Khedri Mohammad‐Reza Mahmoudian‐Sani

An uncommon genetic condition known as Fanconi anemia (FA) is characterized by bone marrow failure, chromosomal instability, and a high susceptibility to cancer. We report a case study of a patient diagnosed with FA who subsequently developed myelodysplastic syndrome (MDS). Informed consent was obtained from the patient’s parents/legal guardians. Consent for publication was obtained from the patient’s parents/legal guardians. We present a case of a 10-year-old boy with a known diagnosis of FA who experienced a decline in platelet count and subsequent bone marrow abnormalities suggestive of MDS. Cytogenetic analysis confirmed the diagnosis of FA with multiple chromosomal breaks, and flow cytometric analysis supported the diagnosis of MDS with excess blasts. The patient underwent a stem cell transplantation from a full matched donor (his father). Stem cell transplantation from a fully matched related donor can be effective in treating FA and associated complications. The transplantation was complicated by graft-versus-host disease and cytomegalovirus infection, however the child achieved complete normalization and exhibited no signs of diarrhea or dependence on immunosuppressive drugs at the six-month follow-up. The case report emphasizes the significance of multidisciplinary care and close follow-up for pediatric FA and MDS patients, suggesting further research and standardization of diagnostic procedures.

10.24287/1726-1708-2024-23-1-149-152

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Impact of COVID-19 acute respiratory disease on the risk factors attributed to cancer patients

Toxicology Reports (2021)

Elena Lak Mohammad Javad Mohammadi Homayon Yousefi

Communicable diseases (CDs) based on Health organization reported are one of the most threat for human health. SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the main pandemic that nowadays it threatens the health of people around the world, especially cancer patients. The purpose of this study was to investigate the effects of COVID-19 acute respiratory disease (COVID-19 ARD) on risk factors related to health of cancer patients. A review study of was conducted to base on results of various studies published. Nine hundred and eighty articles were retrieved based on various databases: Science Direct, Taylor & Francis, Google Scholar, Elsevier, PubMed and BMJ. In this study, were used the results of research on COVID-19 and its effects on risk factors attributed to cancer patients. The literature signs a notable undesirable affect from COVID-19 on risk factors attributed to health of cancer patients. Result showed that transfer SARS-CoV-2 viruses can endanger health of cancer patients due to interruption of the disease treatment process and increase number of deaths between in this patents. The survey requires the need to act creating healthy conditions to continue the treatment process and vaccination coverage among these patients in order to decrease the transmission of COVID-19 acute respiratory disease and increase the success rate of cancer treatment.

Pandemic

10.1016/j.toxrep.2021.12.004

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Citations (8)