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Vatroslav Šerić

University of Osijek

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Sanja Mandić

University of Osijek

Vesna Horvat

University of Osijek

Vesna Babić-Ivančić

University of Osijek

Antun Tucak

Croatian Academy of Sciences and Arts

Dario Mandić

University of Osijek

Ines Drenjančević

University of Osijek

Zvonko Antunović

University of Osijek

MŠ

Marcela Šperanda

University of Osijek

ŽD

Željko Debeljak

University of Osijek

Iva Lukić

University of Osijek

Cooperative Institutions

University of Osijek

201

Klinički bolnički centar Osijek

University of Zagreb

University Hospital Centre Zagreb

Agricultural Institute Osijek

Rudjer Boskovic Institute

Institute for Medical Research and Occupational Health

Institute of Public Health Osijek-Baranja County

University of Split

Andrija Stampar Teaching Institute of Public Health

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Biochemistry of urinary and/or kidney stones

Vesna Babić-Ivančić Vatroslav Šerić Antun Tucak Maja Dutour Sikirić

Urolitijaza, unatoc dugogodisnjim opsežnim fizikalno-kemijskim i metabolickim istraživanjima, kao i razlicitim pristupima, ostaje i dalje do kraja nerazjasnjen proces u organizmu covjeka. Razlog je kompleksna priroda tog visesloženog procesa, a istraživanja koja se provode trebala bi pridonijeti rasvijetljavanju tog problema s naglaskom na efikasnijoj preventivi stvaranja kamenaca koji najcesce nastaje u uvjetima abnormalnog izlucivanja metabolickih cimbenika rizika pojave urolitijaze. U ovom radu u okviru metabolicke obrade mokrace određen je pH urina, kristalurija, te niz biokemijskih parametara u prvom jutarnjem urinu. Tako su određene koncentracije kalcija, magnezija, natrija, kalija, klorida, fosfata, urata, oksalata, citrata, kreatinina te glikozaminoglikana. Iz rezultata dobivenih za biokemijske parametre u urinu racunati su stupanj prezasicenja urina kod kojeg se stvara kamenac, odnos između promovirajucih i inhibirajucih cimbenika stvaranja kamenaca kao i indeksi rizika za nastanak urolitijaze.

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FRACTION EXCRETION OF SODIUM AS A MARKER OF TUBULAR INJURY – IS IT SENSITIVE ENOUGH?

Vesna Horvat Željko Debeljak Sanja Mandić Dario Mandić Vatroslav Šerić

Background. The only promptly avaible testfor early diagnosis of acute kidney failure, so far, is fraction excretion of sodium (FENa). Racent studies indetified neutrophil gelatinase-associated lipocalin (NGAL) as a promising biomarker for such state. The aim of our study was to compare diagnostic usefulness of those analytes in acute tubular impairment caused by bacterial urinary tract infection in children. Methods. We analysed 25 children with static sciantigraphy confirmed diagnosis of acute pyelonephrytis. Serum and urine sodium were measured by ISE, serum creatinine by enzimatic method and urine creatinine by Jaffes method (OLIMPUS AU640, BECKMAN COULTER) in order to calculate FENa. Urine NGAL measurement was performed by CMIA method (ARHITECT i1000, ABBOT). Results. FENa values were in range from 0, 040% to 0, 795%(median 0, 2950), which according to the literature, are all normal values. NGAL values were in range from 17, 9 ng/ml to 1768, 4 ng/ml (median 205, 3) which according to expected normal range of used assay (131, 7) points to acute tubular injury for in 60% of patients. Conclusion. Although FENa is in use as a test for diagnosis of acute renal failure, it is not sensitive enough for detection of minor damage presented in early stage of acute kidney injury. On the other hand, NGAL revealed better sensitivity, and seems to be a better biomarker of minor tubular injury.

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Crystalluria - first step in the stone formation

Vesna Babić-Ivančić Vatroslav Šerić

Kristalizacija koja predstavlja prvu fazu u stvaranju kamenaca, kompleksan je i do kraja nerazjasnjen fenomen, ovisan ne samo o prezasicenosti mokrace, vec također o nizu razlicitih inhibirajucih ili promovirajucih tvari. Promatranje, odnosno detekcija kristalurije, prisutnosti kristala u mokraci (urinu), jedan je od dijagnostickih testova koji je cesto zanemarivan (zapostavljen) od nefrologa i urologa. U ovom radu evaluirana je kristalurija kalcij oksalata (CaOx), kalcij fosfata (CaP) i mokracne kiseline (H2U) u svježe izmokrenim urinima osoba koje stvaraju ili su stvarale kalcijske kamence kao i kod kontrola. Uzorci jutarnjeg urina bili su skupljeni od 62 pacijenta i 35 kontrola a svjetlosna mikroskopija je koristena za detekciju kristalurije. Premda je kristalurija primjecena u obje skupine, ispitanici su imali vise kristala u mokraci nego urini kontrolnih ispitanika. U obje grupe preteže CaOx kristalurija, 13% kod stvaralaca kamenaca i 9% kod kontrola. CaP kristali su bili detektirani u 8% pacijenata i 6% kontrola, dok kristali mokracne kiseline, H2U, su primjeceni kod 2% pacijenata i 3% kontrola. Smjese kristala nisu detektirane. Pokazani su primjeri cescih kristala koji se javljaju u mokraci, a opažanja povezana s kristalnom morfologijom i sastavom mokracnih parametara kao i sastavom kamenaca.

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Consumption of Nutritionally Enriched Hen Eggs Enhances Endothelium-Dependent Vasodilation via Cyclooxygenase Metabolites in Healthy Young People—A Randomized Study

Nutrients (2023)

Petar Šušnjara Zrinka Mihaljević Ana Stupin Nikolina Kolobarić Anita Matić

Objective: The present study aimed to evaluate the effects of enriched hen egg consumption on endothelium-dependent vasodilation (EDV) and the role of cyclooxygenases in EDV in the microcirculation of young healthy individuals. This study hypothesizes that Nutri4 eggs will improve endothelial function, which will be manifested by changes in microcirculatory flow measured by a laser Doppler flowmeter (LDF) during reactive hyperemia in response to vascular occlusion, in which n-3 PUFA plays an important role as well as its degradation pathway by cyclooxygenases. Materials and Methods: Participants consumed three eggs per day for three weeks: The control group (CTRL, n = 14) consumed regular hen eggs (approximately 0.330 mg of lutein, 1.785 mg of vitamin E, 0.054 mg of selenium and 438 mg of n-3 PUFAs daily) and Nutri4 group (n = 20) consumed enriched eggs (approximately 1.85 mg of lutein, 0.06 mg of selenium, 3.29 mg of vitamin E, and 1026 mg of n-3 PUFAs daily). Skin microvascular blood flow in response to EDV (post-occlusive reactive hyperemia (PORH) and iontophoresis of acetylcholine (AChID)) and sodium nitroprusside (SNPID; endothelium-independent) was assessed by laser Doppler flowmetry before and after dietary protocol and in a separate group of participants who were administered perorally 100 mg of indomethacin before microvascular response assessment. Arterial blood pressure, heart rate, serum lipid, and liver enzymes, anthropometric measurements, protein expression of cyclooxygenase 1 (COX-1), cyclooxygenase 2 (COX-2), neuronal nitric oxide synthases (nNOS), inducible nitric oxide synthases (iNOS), and endothelial nitric oxide synthases (eNOS) were measured before and after dietary protocol. Results: PORH and AChID were significantly enhanced, and SNPID remained unchanged in the Nutri4 group, while none was changed in the CTRL following a respective diet. PORH decreased after administration of indomethacin in Nutri4 after dietary protocol. Protein expression of COX-2 was significantly higher in the Nutri4 group compared to the CTRL after the dietary protocol. Conclusion: Consumption of enriched eggs improves microvascular EDV in healthy young subjects. Results suggest an element of n-3 PUFAs metabolites via the cyclooxygenases pathway in enhanced reactive hyperemia.

Reactive hyperemia

Endothelial Dysfunction

Sodium nitroprusside

10.3390/nu15071599

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Etički problem palijativne skrbi u obiteljskoj medicini

Zdravko Ebling Rudika Gmajnić Tibor Santo Vatroslav Šerić

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New insights in laboratory diagnostics in endocrinology

Tatjana Bačun Vatroslav Šerić Ines Šahinović Željko Debeljak Sanja Mandić

U ovom prirucniku za trajno usavrsavanje medicinskih biokemicara dan je prikaz novijih i zapostavljenih tema iz endokrinoloske laboratorijske dijagnostike. U osam poglavlja prirucnik se bavi temama iz laboratorijske metodologije i tehnologije te primjenom metoda u dijagnostici feokromocitoma, karcinoida, neuroblastoma, prirođene adrenalne hiperplazije, bolesti stitnjace, dijabetesa i poremecaja funkcije gonada.

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Comparison of methods for determination of HbA1c

Jasna Jonjić Sanja Mandić Vesna Horvat Vatroslav Šerić Neda Majetić-Cetina

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Promjena acidobazne ravnoteže krvi u lakon ovaca tijekom različitih stadija laktacije

Poljoprivreda (2022)

Zvonko Antunović Boro Mioč Željka Klir Šalavardić Ivan Širić Valentino Držaić

The aim of the present study was to determine the acid-base balance in the blood of the Lacaune sheep during different lactation stages. Thirty lactating Lacaune sheep were involved in the research, and were monitored in the early (day 60), medium (day 120), and late lactation stages (day 180). The following parameters were determined in the blood plasma: pH, partial pressure of carbon dioxide – pCO2, partial pressure of oxygen – pO2, total pressure of carbon dioxide – tCO2, oxygen saturation – sO2, actual base excess Cbase – B, standard base excess Cbase – Ecf and electrolytes (Na+, K+, Ca2+, Cl- and HCO3- – bicarbonate), while total proteins – TP and albumin ALB were determined in the serum. Also, strong ion difference - SID, z value, anion gap - AG, weak anions, and cations - ATOTtp and ATOTalb, strong ion gap - SIG, unmeasured anions – XA and globulin concentrations were calculated. A significant effect of the lactation stage on most of the acid-base parameters in the blood of the Lacaune sheep was determined, except for pCO2, Cl-, z values and the SID. A significant increase of pO2, sO2, ATOTtp, ATOTalb, AG, SIGalb, SIGtp, XA, Na+, total proteins and albumins, as well as the decreased concentrations of K+ and Ca2+, were determined in the blood of the Lacaune sheep during lactation. During the medium stage of lactation, significant changes were determined in most of the acid-base parameters in the blood of the Lacaune sheep when compared to the other stages. A lactation stage may significantly affect the acid-base balance parameters in the blood of the Lacaune sheep, although the calculations of SIG, base excess (BE), and unmeasured anion (XA) values should also be included for the obtainment of a more comprehensive picture of the acid-base balance.

Bicarbonate

Acid–base homeostasis

Base excess

pCO2

10.18047/poljo.28.2.8

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Crystalluria Observed by Light Microscopy

Vesna Babić-Ivančić Vatroslav Šerić

Crystalluria

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