Alejandra M. Manjarrez-Casas

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Akos Dobay

University of Zurich

Homayoun C. Bagheri

University of Zurich

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University of Zurich

Ludwig-Maximilians-Universität München

Helmholtz Zentrum München

Universität Hamburg

University Medical Center Hamburg-Eppendorf

SIB Swiss Institute of Bioinformatics

University of California, Santa Barbara

Center for Integrated Protein Science Munich

Duquesne University

University of Washington

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Transition from one- to two-dimensional development facilitates maintenance of multicellularity

Royal Society Open Science (2016)

Alejandra M. Manjarrez-Casas Homayoun C. Bagheri Akos Dobay

Filamentous organisms represent an example where incomplete separation after cell division underlies the development of multicellular formations. With a view to understanding the evolution of more complex multicellular structures, we explore the transition of multicellular growth from one to two dimensions. We develop a computational model to simulate multicellular development in populations where cells exhibit density-dependent division and death rates. In both the one- and two-dimensional contexts, multicellular formations go through a developmental cycle of growth and subsequent decay. However, the model shows that a transition to a higher dimension increases the size of multicellular formations and facilitates the maintenance of large cell clusters for significantly longer periods of time. We further show that the turnover rate for cell division and death scales with the number of iterations required to reach the stationary multicellular size at equilibrium. Although size and life cycles of multicellular organisms are affected by other environmental and genetic factors, the model presented here evaluates the extent to which the transition of multicellular growth from one to two dimensions contributes to the maintenance of multicellular structures during development.

Multicellular organism

10.1098/rsos.160554

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Effects of antibiotics on individual bacterial cells

Alejandra M. Manjarrez-Casas

10.3929/ethz-b-000309075

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