Benoît Colasson

Université Paris Cité

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Olivia Reinaud

Université Paris Cité

Luigi Fabbrizzi

University of Pavia

Massimo Boiocchi

University of Pavia

Ivan Jabin

Université Libre de Bruxelles

Valeria Amendola

University of Pavia

Nicolas Le Poul

Laboratoire Chimie Electrochimie Moléculaires et Chimie Analytique

Aleksandar Višnjevac

Rudjer Boskovic Institute

Andrea Brugnara

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques

Michel Luhmer

Université Libre de Bruxelles

Yves Le Mest

Laboratoire Chimie Electrochimie Moléculaires et Chimie Analytique

Cooperative Institutions

Centre National de la Recherche Scientifique

Université Paris Cité

Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques

Université Libre de Bruxelles

Sorbonne Paris Cité

Laboratoire de Chimie Organique

Sorbonne Université

Délégation Paris 6

Laboratoire de Chimie

Délégation Paris 5

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Synthesis of C_3v-Symmetrical 1,3,5-Tris-Protected Calix[6]arene-Based Molecular Platforms

The Journal of Organic Chemistry (2024)

Martin Lepeintre Julie Champciaux Benoît Colasson Ivan Jabin

Few synthetic methodologies that yield tris-functionalized C3v-symmetrical calix[6]arenes have been reported. In this work, three allyl protecting groups are selectively placed in 1,3,5 alternate positions of three pristine calix[6]arenes, each differing by their substituent on the large rim, resulting in three new C3v-symmetrical molecular platforms. Removal of the protecting allylic groups gives access to sophisticated calix[6]arenes that can be further modified. The potential of these new C3v-symmetrical molecular platforms is notably exemplified through the development of a new family of calix[6]arene-based N ligands.

Calixarene

10.1021/acs.joc.3c02790

Cite

Citations (0)

Transition Metals Coordination by Bis-imidazole-calix[4]arene Ligands with and Without Pyrene Units Grafted at the Large Rim

International Journal of Molecular Sciences (2024)

Ivana Nikšić‐Franjić Dijana Saftić Vilko Smrečki Benoît Colasson Olivia Reinaud

Herein, the presented results show that previously studied DNA/RNA-interacting bis-imidazole-calix[4]arene systems can, in aqueous solutions, efficiently bind a series of biorelevant transition metal cations by coordination with the two imidazole arms at the small rim of their macrocyclic basket. The SCXRD and NMR results structurally characterised the complexes formed by referent bis-imidazole-calix[4]arene with Cu

Imidazole

Coordination complex

Calixarene

10.3390/ijms252011314

Cite

Citations (0)

Selective Metal‐ion Complexation of a Biomimetic Calix[6]arene Funnel Cavity Functionalized with Phenol or Quinone

Chemistry - A European Journal (2022)

Pamela Aoun Nicolas Nyssen S.B. Richard Fedor E. Zhurkin Ivan Jabin

In the biomimetic context, many studies have evidenced the importance of the 1st and 2nd coordination sphere of a metal ion for controlling its properties. Here, we propose to evaluate a yet poorly explored aspect, which is the nature of the cavity that surrounds the metal labile site. Three calix[6]arene-based aza-ligands are compared, that differ only by the nature of cavity walls, anisole, phenol or quinone (LOMe , LOH and LQ ). Monitoring ligand exchange of their ZnII complexes evidenced important differences in the metal ion relative affinities for nitriles, halides or carboxylates. It also showed a possible sharp kinetic control on both, metal ion binding and ligand exchange. Hence, this study supports the observations reported on biological systems, highlighting that the substitution of an amino-acid residue of the enzyme active site, at remote distance of the metal ion, can have strong impacts on metal ion lability, substrate/product exchange or selectivity.

Lability

10.1002/chem.202202934

Cite

Citations (5)

Ligand exchange in TREN-based Cobalt (II) funnel complexes in the solid state

Nicolas Nyssen Gaël De Leener Michel Luhmer Benoît Colasson Ivan Jabin

The coordination of CoII with two calixarene-based TREN [tris(2-aminoethyl)amine] ligands is reported. The two ligands differ for the presence of three anisole groups (in Calix-TRENMe) or three phenol groups (in Calix-TRENH) in the macrocyclic structure surrounding the CoIITREN core. Dicationic complexes were synthesized and fully characterized both in solution and in the solid state. Surprisingly, a crystal-to-crystal transformation led to the substitution of the acetonitrile guest ligand by a pair of H-bonded water molecules. This gave rise to the first example of an X-ray characterized aqua-complex with a CoII center confined in a neutral, 5-coordinate N4(OH2) environment.

Funnel

10.26434/chemrxiv-2025-mg4q6

Cite

Citations (0)

CCDC 612694: Experimental Crystal Structure Determination

The Cambridge Structural Database (2007)

Valeria Amendola Massimo Boiocchi Benoît Colasson Luigi Fabbrizzi M.-J.R. Douton

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccnkkb2

Cite

Citations (0)

Development of a water-soluble ouroboros-like calix[6]arene-trisimidazole-based ligand for enhanced binding of zinc

Dalton Transactions (2024)

Romain Carpentier Roy Lavendomme Benoît Colasson Kristin Bartik Ivan Jabin

An ouroboros-like calix[6]arene-trisimidazole-based ligand was developed for the coordination of zinc in water.

Calixarene

10.1039/d4dt03158j

Cite

Citations (0)

Kinetic and Thermodynamic Stabilization of Metal Complexes by Introverted Coordination in a Calix[6]azacryptand

Chemistry - A European Journal (2016)

Alex Inthasot Emilio Brunetti Manuel Lejeune Nicolas Menard T. Prangé

Abstract The Huisgen thermal reaction between an organic azide and an acetylene was employed for the selective monofunctionalization of a X 6 ‐azacryptand ligand bearing a tren coordinating unit [X 6 stands for calix[6]arene and tren for tris(2‐aminoethyl)amine]. Supramolecular assistance, originating from the formation of a host–guest inclusion complex between the reactants, greatly accelerates the reaction while self‐inhibition affords a remarkable selectivity. The new ligand possesses a single amino‐leg appended at the large rim of the calixarene core and the corresponding Zn 2+ complex was characterized both in solution and in the solid state. The coordination of Zn 2+ not only involves the tren cap but also the introverted amino‐leg, which locks the metal ion in the cavity. Compared with the parent ligand deprived of the amino‐leg, the affinity of the new monofunctionalized X 6 tren ligand 6 for Zn 2+ is found to have a 10‐fold increase in DMSO, which is a very competitive solvent, and with an enhancement of at least three orders of magnitude in CDCl 3 /CD 3 OD (1:1, v/v). In strong contrast with the fast binding kinetics, decoordination of Zn 2+ as well as transmetallation appeared to be very slow processes. The monofunctionalized X 6 tren ligand 6 fully protects the metal ion from the external medium thanks to the combination of a cavity and a closed coordination sphere, leading to greater thermodynamic and kinetic stabilities.

Calixarene

Coordination sphere

Transmetalation

Coordination complex

10.1002/chem.201505057

Cite

Citations (9)

Remote electrochemical modulation of pK _a in a rotaxane by co-conformational allostery

Proceedings of the National Academy of Sciences (2017)

Giulio Ragazzon Christian Schäfer Paola Franchi Serena Silvi Benoît Colasson

Significance Rotaxanes are species in which a macrocyclic molecule—the ring—is interlocked with a dumbbell-shaped component—the axle. The translational motion of the ring along the axle provides the basis for constructing molecular machinery. In this paper we show that such a dynamic process enables the transfer of chemical information between two distant sites; as a result, the acidity of one site can be reversibly modulated by redox switching at the other site. Possibilities emerge not only for the rational design of species with tailor-made acid–base properties but also for the development of model systems to understand some of Nature’s most effective regulatory mechanisms—namely, allostery and proton-coupled electron transfer.

Rotaxane

Dumbbell

Molecular machine

10.1073/pnas.1712783115

Cite

Citations (33)

Electrochemically Driven Cup‐and‐Ball Cu^I and Cu^II Complexes

Chemistry - A European Journal (2013)

Nicolas Menard Yohann Hériot Yves Le Mest Olivia Reinaud Nicolas Le Poul

Abstract The conformation of copper “funnel” complexes that contains a coordinating appended arm can be electrochemically switched between endo , which corresponds to the self‐coordination of the arm through the cavity, and exo positions. This process, which is reminiscent of a cup‐and‐ball device, is activated by an exogenous ligand for complexes that contain a hydroxy‐terminated arm. The exchange is electrochemically triggered and is operated in either Cu I or Cu II redox states, depending on the exogenous ligand, that is, CO or n ‐butylamine, respectively.

Funnel

Ball (mathematics)

10.1002/chem.201301141

Cite

Citations (11)

A Metal‐Based Trisimidazolium Cage That Provides Six CH Hydrogen‐Bond‐Donor Fragments and Includes Anions

Angewandte Chemie International Edition (2006)

Valeria Amendola Massimo Boiocchi Benoît Colasson Luigi Fabbrizzi M.J. Rodriguez-Douton

Sheltering under the roof: A trisimidazolium cage is capped with a {FeII(bpy)3}2+ subunit to produce a receptor that can bind small anions (bpy=2,2′-bipyridine). Rodlike "pseudohalide" (N3−, NCO−, and NCS−) and spherical halide (Cl−, Br−, and I−) anions accept hydrogen bonds from CH fragments in the receptor cavity. The N3− ion forms the most stable inclusion compound (see structure; Fe red, C light blue, H white, N dark blue). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z602598_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Cage

10.1002/anie.200602598

Cite

Citations (115)