Takeharu Itatsu

Japanese Red Cross Nagoya Daini Hospital

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Mitsuo Ukai

Nagoya University

Akemi Inagaki

Toyota Central Research and Development Laboratories (Japan)

KAZUYUKI YAMAUCHI

Kitami Institute of Technology

A Tomita

Nagoya University

Kensuke Takatsuki

Nagoya University

Seiko Taguchi

Nagoya University

Iwao Hara

Iwaki Kyoritsu General Hospital

Sayaka Suzuki

Japan Small Animal Medical Center

Naruki Matsuda

Red Cross Hospital

Mitsune Tanimoto

Okayama University

Cooperative Institutions

Nagoya University

Red Cross Hospital

Japanese Red Cross Nagoya Daini Hospital

Aichi Medical University

Japanese Red Cross Nagoya Daiichi Hospital

Nagoya City University

Mie University

Higashi Nagoya National Hospital

Kyoto University

The University of Tokyo

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Clinical evaluation of the filter paper disc as a gustometric testing method about taste impairment in patients with diabetes mellitus.

The Japanese Journal of Nutrition and Dietetics (1984)

Takashi Yamada Yoko Kitoh Takeharu Itatsu Yasuo Ishiguro Yuko Kitagawa

A qualitative and quantitative gustometric testing method using the filter paper disc on sweet, salty and sour tastes was evaluated in 30 patients with diabetes mellitus (type II, NIDDM) and in 30 healthy subjects (volunteers) in our hospital.The following results were obtained in this study.1) The threshold of salty and sour tastes in diabetic patients obviously elevated in contrast to those in healthy subjects.2) The total score which was calculated by the sum of each score about sweet, salty and sour tastes, significantly lowered in diabetic patients (diabetes vs healthy; 18.5±8.9 vs 27.4±9.6, p<0.01), especially so in the patients with complications with microangiopathies (diabetes vs healthy; 13.1±11.7 vs 27.4±9.6, p<0.01).3) Patients who have been afflicted with diabetes for more than 10 years show the lower total scores of three tastes compared to those who have suffered the disease for less than 10 years (more than 10 years vs less than 10 years; 11.0±10.5 vs 20.6±7.2, p<0.01).4) The total scores rose considerably in some of diabetic patients after the improvement of fasting blood glucose levels by diet alone (before vs after; 16.5±8.3 vs 23.0±6.6, p<0.01).It is concluded that the gustometric testing method using the filter paper disc may be useful in clinical evaluation of the taste impairment in patients with diabetes mellitus.

10.5264/eiyogakuzashi.42.235

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Inhibition of neurotensin (NT)-induced glucagon release by [D-Trp11]-NT1

Experientia (1982)

Mitsuo Ukai Takeharu Itatsu A Shibata Francis Rioux S. St‐Pierre

Hyperglucagonemia

Pancreatic Islets

10.1007/bf01959752

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Citations (1)

Association of HLA Antigen and Restriction Fragment Length Polymorphism of T Cell Receptor β- Chain Gene with Graves' Disease and Hashimoto's Thyroiditis*

The Journal of Clinical Endocrinology & Metabolism (1989)

Masafumi Ito Mitsune Tanimoto Hiromi Kamura Masahiro Yoneda Yasuo Morishima

HLA antigen phenotypes and BglII restriction fragment length polymorphism of T cell receptor β-chain (TCRβ) gene were analyzed in 61 patients with Graves' disease and 50 patients with Hashimoto's thyroiditis. The antigen frequency of HLA-Bw46 in both Graves' disease (23.0%) and Hashimoto's thyroiditis (24.0%) was significantly higher than that in normal population (8.0%), with relative risks (RR) of 3.45 [corrected P (Pc) < 0.009] and 3.66 (Pc < 0.02), respectively. Significantly increased frequency of HLA-B51 antigen was also found in Hashimoto's thyroiditis (40.0% vs. 16.3% in controls; RR, 3.42; Pc < 0.002). Hybridization of BglII-digested DNA with TCRβ probe revealed two alleles of 9.3 and 8.6 kilobases. The allele frequency of 8.6 kilobases in Graves' disease (79%) and Hashimoto's thyroiditis (76%) was significantly higher (P < 0.01 and P < 0.05, respectively) than that in controls (64%). The frequency of homozygous state 8.6/8.6 was significantly increased in both Graves' disease (62%) and Hashimoto's thyroiditis (60%) over that in controls (39%); the RR of 8.6/8.6 in Graves' disease and Hashimoto's thyroiditis were 2.55 (P < 0.01) and 2.31 (P < 0.05), respectively. These results indicate that in Japanese subjects at least two loci are involved in the susceptibility to Graves' disease and Hashimoto's thyroiditis, one related to HLA and another to TCRβ.

Thyrotropin receptor

10.1210/jcem-69-1-100

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The Japanese Journal of Nutrition and Dietetics (1980)

Yoko Iwata Yasuo Ishiguro Yuko Ohhara Takashi Yamada Take Sakurai

Six female patients with anorexia nervosa, who met the criteria shown by Halmi et al. or Suematsu, were treated by dietary therapies with behavioral modification and no medication, being compared with another six female patients treated by psychiatric counsel alone. Their lives in the hospital were restricted and isolated from their own families and relatives for the early period of admission, in which psychiatric counsels were regularly performed.In dietary therapy the meal contained 1200kcal per day for the first time and was gradually added by 200kcal per day at an interval of 7 to 14 days as the patients could eat completely. However, in patients who were severely undernourished and showed no desirable eating attitude nor modest weight gain, they were further given a nutrient such as "Sustagen" (200-400kcal per day) between meals. The gain of mean weight from 32kg to 42kg was found within a year by such diet therapies, while by psychiatric counsel alone that from 32kg to 45kg was visible within several years.It is concluded that these dietary therapies with behavioral modification may be useful to facilitate the patient's return to a regular eating attitude and ideal body weight.

Anorexia nervosa

Anorexia

10.5264/eiyogakuzashi.38.257

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A CASE OF 17α-HYDROXYLASE DEFICIENCY WITH BONE ANOMALIES

Nihon Naika Gakkai Zasshi (1980)

Takeharu Itatsu Keiko Naitoh Naruki Matsuda Nobuo Matsui

1966年Biglieriにより,原発性無月経・高血圧・低K血性アルカローシスを主徴とする17α-hydroxylase欠損症が初めて報告された.その後の報告の中で,男性例は仮性半陰陽を示すことが記載された.一般にDOC,コルチコステロンの異常分泌亢進,コーチゾル,性ステロイドの分泌低下と共にアルドステロソ分泌低下が認められる. Biglieri-Goldsmith型の男性仮性半陰陽4例と女性性腺機能低下症5例が,本邦でも報告されたが,希な疾患とされる.我々は, 17α-hydroxylase欠損に該当すると思われる女性例で種々の骨畸型(外反肘,右第4趾中足骨の短縮,胸腰椎側湾)を示した症例を経験した.従来の報告の中で高身長やosteoporosisについての記載はみちれるが,本症の如き骨畸型の合併についての記載はない.本症における染色体分析は, 46XXのKaryo typeであり,検出されるHLAは, A9・B31・B35・B52であつた.エストロジェンとプロゲステロンおよびデキサメサゾン(0.5～1.0mg/日)による2年間の治療経過中,身長の伸び(2cm)と体重の増加(10kg)と同時に両側大腿前面に横走する赤い皮膚伸展線を認めた.デキサメサゾンにより低K血症の速やかな改善がみられたのに比し,高血圧の十分な改善が得られなかつた.スピロノラクトンの併用により,血圧の改善がさらに認められ,その後になつて初めてアルドステロン分泌が正常化するのが観察された.

21-Hydroxylase

10.2169/naika.69.960

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Citations (6)

Effect of ethionine on carbohydrate and lipid metabolism

Journal of Lipid Research (1973)

H. Tani K Ogata Takeharu Itatsu

In ethionine-treated rats, the ATP content of adipose tissue was not decreased whereas in liver it was drastically reduced to about one-fifth of the control level.Shortly after the injection of ethionine, hepatic glycogen was depleted and the blood glucose concentration fell from 120 to 80 mg/100 ml.This was followed by a two-to threefold elevation of the plasma fatty acid level.Hepatic glucose-6-phosphate was decreased and was not elevated by administration of 2 mmoles of glucose unless ATP was partially restored to normal levels.When hepatic ATP was decreased, the disappearance of [*4C]glucose from the blood and its incorporation into glycogen and glyceride-glycerol and the incorporation of [3-14C]pyruvate into glyceride-glycerol were reduced.6 hr after ethionine injection the plasma triglyceride level fell but there was no significant change in the liver triglyceride concentration, but by 24 hr it had increased markedly.Lipogenesis in adipose tissue was depressed in vivo, possibly due to decreased glycerol-3-phosphate concentrations.A marked decrease of glycerol-3-phosphate in both liver and adipose tissue was noted.Administration of glucose ef- fectively depressed plasma free fatty acid concentration and elevated the glycerol-3-phosphate levels.Ethionine injection to fasted animals further depressed the blood glucose and elevated the plasma free fatty acid level.Supplementary key words ATP .hepatic glycogen .glucose-6-phosphate .gluconeogenesis .blood glucose .plasma free fatty acid .glycerol-3-phosphate .

Ethionine

Lipogenesis

Glyceride

Gluconeogenesis

Ketogenesis

10.1016/s0022-2275(20)39326-3

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Citations (15)

Follicle-stimulating hormone producing pituitary adenoma with hyponatremia.

Nihon Naika Gakkai Zasshi (2002)

Mayumi Nakamura Akemi Inagaki Kosei Esaki Seiko Taguchi Ryoichi Banno

73歳,女性.主訴は全身倦怠感.血清Na119mEq/lにて入院. ACTH,コルチゾールとも低値,日内変動も消失. LH低値, FSH673mIU/mlと著明高値.四者負荷試験ではLHは低反応, FSHは高値低反応, ACTHとTSHは視床下部性機能不全のパターン.頭部MRIで下垂体部に鞍上部へ進展する腫瘍を認めた.本例の如く著明なFSH高値を示すgonadotroph adenomaの報告は少なく貴重と思われる.

10.2169/naika.91.480

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Age of onset possibly associated with the degree of heteroplasmy in two male siblings with diabetes mellitus having an A to G transition at 3243 of mitochondrial DNA

Diabetic Medicine (2002)

Yuzuru Kato Yoshitaka Miura Akemi Inagaki Takeharu Itatsu Yutaka Oiso

Abstract We describe two male siblings with diabetes mellitus caused by mitochondrial 3243 mutation. The level of heteroplasmy in peripheral blood leucocytes was determined by a last‐cycle hot PCR method. The younger brother, who had 39% heteroplasmy, developed diabetes at age of 25, and demonstrated a lean body habitus and blunted insulin secretion. The elder brother, who had 22% heteroplasmy, was diagnosed at the age of 42. The younger brother showed a higher increment of serum lactate after exercise. In these siblings the level of heteroplasmy in their peripheral blood leucocytes appeared to be associated with age of onset of diabetes.

Heteroplasmy

10.1046/j.1464-5491.2002.00777.x

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Citations (9)

Role of the Clinical Pharmacist in Pharmaceutical Care

Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) (2005)

Yuki Ito Tetsuo Ando Toshiharu Arakawa Toshitaka Nabeshima Takeharu Itatsu

The major requirement for the hospital pharmacist is the practice of good pharmaceutical care. In this study, we examined the content of such pharmaceutical care and whether the average number of drugs, drug costs and the incidence of adverse drug events was reduced by the presence of the pharmacist in the neurology ward of Nagoya Daini Red Cross Hospital. We also considered ways of improving the function of clinical pharmacists in the future.The number of the clinical pharmacy practices for the month of September 2000 was 762 broken down into dispensing of drugs, consultation with patients and other clinical pharmacy practices, with 198, 338 and 226 practices each, respectively. The greatest proportion of other clinical pharmacy practices involved supplying drug information, with advice on prescription changes and amending prescriptions coming next. The number of the clinical pharmacy practices increased from 762 in 2000 to 893 in 2003, with practices covering a broad range of functions, all needing specialist pharmaceutical knowledge. Over this period, the average number of drugs in prescriptions, drug costs and incidence of adverse drug events decreased, which resulted from pharmacists ensuring that drugs were used properly by amending prescriptions.A major goal of clinical pharmacists is to ensure that drugs are used properly and this can be achieved through their active involvement in all aspects of pharmaceutical care as an active member of the health care team. Their role should not be limited to instructing patients on how to take drugs.

Pharmaceutical Care

10.5649/jjphcs.31.113

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Citations (11)

Effect of Somatostatin on Neurotensin-Induced Glucagon Release and Hyperglycemia

Endocrinology (1977)

Mitsuo Ukai Itaru Inoue Takeharu Itatsu

Administration of neurotensin to dogs resulted in rises in circulating blood glucose, glucagon and insulin levels, the rise in glucagon being more pronounced than that in insulin. Infusion of somatostatin along with neurotensin suppressed glucagon and insulin responses to neurotensin and prevented the rise in blood glucose levels. These results suggest that the hyperglycemia seen after neurotensin is due to neurotensin stimulation of glucagon release over insulin release. (Endocrinology100: 1284, 1977)

10.1210/endo-100-5-1284

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Citations (36)