Weilong Xu

China Agricultural University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Yingru Zhao

China Agricultural University

Yaoguo Qin

China Agricultural University

Yongheng Zhang

Risun (China)

Dexing Ye

China Agricultural University

Yuanlin Zhou

Southwest University of Science and Technology

Haoyuan Feng

China Agricultural University

Xinling Yang

China Agricultural University

Chandni Iqbal

China Agricultural University

Xuesheng Li

Guangxi University

Yimeng Zhang

Xidian University

Cooperative Institutions

China Agricultural University

Chinese Academy of Agricultural Sciences

Guangxi University

Xi'an Jiaotong University

Southwest Petroleum University

Chinese Academy of Medical Sciences & Peking Union Medical College

Institute of Plant Protection

Tennessee State University

Ministry of Agriculture and Agro Based Industry

Ministère de l'Agriculture et de la Souveraineté alimentaire

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Insect kinin mimics act as potential control agents for aphids: Structural modifications of Trp⁴

Journal of Peptide Science (2022)

Yuanlin Zhou Yimeng Zhang Yongheng Zhang Yingru Zhao Weilong Xu

Insect kinins are endogenous, biologically active peptides with various physiological functions. The use of insect kinins in plant protection is being evaluated by many groups. Some kinins have been chosen as lead compounds for pest control. We previously reported an insect kinin mimic IV-3 that had insecticidal activity. And by introducing a strong electron withdrawing group (-CF3 ) on the benzene ring (Phe2 ), we discovered a compound, L7 , with better activity than lead IV-3. In this work, taking L7 as the lead compound, we designed and synthesized 13 compounds to evaluate the influence of position 4 (Trp4 ) of insect kinin on insecticidal activity, by replacing the H atom on tryptophan with -CH3 and -Cl or substituting the indole ring of tryptophan with the benzene, naphthalene, pyridine, imidazole, cyclohexane, and alkyl carboxamides. The aphid bioassay results showed that the compounds M1 , M3 , and M5 were more active than the positive control, pymetrozine. Especially, replacing the side chain by an indole ring with 4-Cl substitution (M1 , LC50 = 0.0029 mmol/L) increased the aphicidal activity. The structure-activity relationships (SARs) indicated that the side chain benzene ring at this position may be important to the aphicidal activity. In addition, the toxicity prediction by Toxtree, and the toxicity experiments on Apis mellifera suggested that M1 was no toxicity risk on a non-target organism. It could be used as a selective and bee-friendly insecticide to control aphids.

DEET

10.1002/psc.3444

Cite

Citations (3)