Xiaoqiong Liu

Lanzhou University

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Co-Authors

Guang Li

Hokkaido University

Heng Fan

University of North Texas

Kunlun Chen

First Affiliated Hospital of Zhengzhou University

Michael G. Brattain

University of Nebraska Medical Center

Karen K. Kuropatwinski

Roswell Park Comprehensive Cancer Center

Ashwani Rajput

Watford General Hospital

Jennie Hauser

Roswell Park Comprehensive Cancer Center

Jingtian Tang

Ministry of Natural Resources

Jing Wang

Chinese Academy of Medical Sciences & Peking Union Medical College

Qi Zeng

Sun Yat-sen University

Cooperative Institutions

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

Sun Yat-sen University

Qilu Hospital of Shandong University

Shandong University

Central South University

University of Chinese Academy of Sciences

University of Nebraska Medical Center

Peking University

Lanzhou University

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Certificateless-based Two-party Authenticated Key Agreement Protocol

Xiaoqiong Liu

A certificateless-based two-party authenticated key agreement protocol is proposed based on bilinear pairings in elliptic curves,the elliptic curve discrete logarithm problem and CDH.Avoiding the key escrow issues inheried in the identity-based schemes effectively and preventing active attack by identity authentication.After confirming the correctness,the formal analysis based on applied pi calculus shows fulfilled authentication and secure.Compared with other two-party authenticated key agreement protocols,the newly proposed key agreement protocol has better security and efficiency.

Key escrow

Key-agreement protocol

Mutual authentication

Discrete logarithm

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Citations (1)

Study on the Evaluation of Sustainable Agricultural and Rural Development in the Yellow River Basin

wu jiayao Xiaoqiong Liu

Agricultural Development

10.2139/ssrn.5056530

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Perturbation of the Bcl-2 Network and an Induced Noxa/Bcl-xL Interaction Trigger Mitochondrial Dysfunction after DNA Damage

Journal of Biological Chemistry (2010)

Hernando López-Bertoni Liqiang Zhang Nicholas M. George Xiaoqiong Liu Xiaming Pang

How most apoptotic stimuli trigger mitochondrial dysfunction remains to be resolved. We screened the entire Bcl-2 network for its involvement in DNA damage-induced apoptosis in HeLa cells. Although the anti-apoptotic member Bcl-xL served as a major suppressor, apoptosis initiated only when both Mcl-1 and Bcl-xL were eliminated. The pro-apoptotic members Bak, Bad, Bim, and Noxa were required for apoptosis induced by DNA damaging agents camptothecin and UV. We, therefore, used a His-tagged Bcl-xL expression system to capture the relevant BH3-only proteins that bind to Bcl-xL in response to DNA damage. Surprisingly, unlike Bad and Bim, which bound Bcl-xL constitutively, Noxa became "Mcl-1-free" and interacted with Bcl-xL after DNA damage but not after death receptor engagement. Similar observations were also made in A431 cells. Importantly, this induced interaction caused cytochrome c release and apoptosis and was directly inhibited by Mcl-1, a protein eliminated or inactivated after DNA damage. These results suggest that the loss/inactivation of Mcl-1 in conjunction with an induced Noxa/Bcl-xL interaction may serve as a trigger for mitochondrial dysfunction during DNA damage-induced apoptosis.

Bcl-xL

HeLa

Puma

Bcl-2 Family

10.1074/jbc.m109.086231

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Citations (55)

Resveratrol‐enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice

Journal of Cellular and Molecular Medicine (2014)

Bo Wang Qing Yang Yuan‐yuan Sun Yifan Xing Ying‐bin Wang

Abstract Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect on diabetic cardiomyopathy. Whether the resveratrol‐induced improvement in cardiac function in diabetes is via regulating autophagy remains unclear. We investigated the mechanisms underlying resveratrol‐mediated protection against heart failure in diabetic mice, with a focus on the role of sirtuin 1 ( SIRT 1) in regulating autophagic flux. Diabetic cardiomyopathy in mice was induced by streptozotocin ( STZ ). Long‐term resveratrol treatment improved cardiac function, ameliorated oxidative injury and reduced apoptosis in the diabetic mouse heart. Western blot analysis revealed that resveratrol decreased p62 protein expression and promoted SIRT 1 activity and Rab7 expression. Inhibiting autophagic flux with bafilomycin A1 increased diabetic mouse mortality and attenuated resveratrol‐induced down‐regulation of p62, but not SIRT 1 activity or Rab7 expression in diabetic mouse hearts. In cultured H9C2 cells, redundant or overactive H 2 O 2 increased p62 and cleaved caspase 3 expression as well as acetylated forkhead box protein O1 ( FOXO 1) and inhibited SIRT 1 expression. Sirtinol, SIRT 1 and Rab7 si RNA impaired the resveratrol amelioration of dysfunctional autophagic flux and reduced apoptosis under oxidative conditions. Furthermore, resveratrol enhanced FOXO 1 DNA binding at the Rab7 promoter region through a SIRT 1‐dependent pathway. These results highlight the role of the SIRT 1/ FOXO 1/Rab7 axis in the effect of resveratrol on autophagic flux in vivo and in vitro , which suggests a therapeutic strategy for diabetic cardiomyopathy.

Diabetic Cardiomyopathy

Sirtuin 1

10.1111/jcmm.12312

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Citations (197)

Controlled Source Electromagnetic Data Denoising Based On CEEMD and Correlation Analysis

Di Ding Li Guang Zhushi He Xiaoqiong Liu Zheng Hao-hao

Controlled-source electromagnetic method (CSEM) signals are inevitably contaminated by man-made noises. For this reason, a new CSEM data processing method was proposed. First, the 50 Hz powerline interference was removed by FFT method, followed by the CEEMD method to remove baseline drift, and finally the correlation analysis method was used to select the high-quality signal. The method was applied to the processing of measured data in Huidong, Sichuan. As a conclusion, the presented method can effectively remove the strong cultural noise from raw CSEM data and preserve the useful signal completely; the apparent resistivity curves acquired by using the filtered data are improved significantly upon the previous.

SIGNAL (programming language)

Data Processing

10.1109/icisce50968.2020.00458

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Direction of Underground Water Exploitation in Hilly Areas in Tai'an City

Xiaoqiong Liu

From the fall of 2010 to the spring of 2011,there's no effective rainfall in Tai'an city.Tai'an city has encountered successive drought in autumn,winter and spring,This kind of meteorological drought rarely happens in this city.Thus,the departments of land resources and geological exploration units in Tai'an city have been organized by the government to carry out the work of water exploration,wells location and wells digging to fight for drought.The department which the author works for is designated as the executive of the work.According to practices of this work,combining with regional hydrogeological conditions in Tai'an city,directions for underground water exploration in the hilly areas in Tai'an city have been pointed out,which will provide some references for colleagues for water exploitation and wells location.

Digging

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Efficient identity-based signature algorithm without certificate

Jisuanji gongcheng yu sheji (2011)

Xiaoqiong Liu

To improve the efficiency and security of network authentication,an efficient Identity-based signature algorithm using bilinear pairing technology without certificate is proposed.The private key of user is decided by key generation center and the user himself,apply to the key generation center is not very trust occasions.Once the private key is leaked,user generates the new public key through the algorithm,preventing hackers to forge signature and solving the key revocation problem.In precondition of unchangeable public key of user,the communications server need not to maintain a certification list of common words,by calculating the index number will be able to authenticate the user identity.In addition,the algorithm has the anonymity and non-repudiation.Finally,a brief analysis of algorithm performance and based on the random oracle model show that the algorithm under adaptive chosen message attack can not be forged.

Key generation

Session key

Implicit certificate

Digital Signature Algorithm

Source

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Comparative lipidomics analysis reveals changes in lipid profile of Arabica coffee at different maturity

Food Chemistry X (2024)

Yanbing Wang Xiaoyuan Wang Xiaogang Liu Xiaoqiong Liu Lirong Li

This study aimed to investigate the effects of maturity on the changes in major lipid metabolites of coffee and their associated pathways. UPLC-ESI-MS/MS was used to compare the lipidomic profiles of coffee beans at five different maturity stages. A total of 516 lipid metabolites across 26 subclasses were identified, with 111 showing significant differences. Glycerolipids (GL) and fatty acyls (FA) were the most abundant, followed by glycerophospholipids (GP), sphingolipids (SP) and prenol lipids (PR). PCA and OPLS-DA analyses demonstrated significant changes in coffee lipids during maturation. Glycerophospholipid metabolism and glycerolipid metabolism were identified as key metabolic pathways, with phosphatidic acid (PA), lysophosphatidic acid (LPA) and diacylglycerol (DG) as key lipid metabolites in these pathways during coffee maturation. Lipids in immature and overripe beans were significantly different from those in mature coffee beans. This study provides a foundational understanding of lipid transformation and flavor profile formation during coffee maturation.

Arabica coffee

10.1016/j.fochx.2024.102062

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Supplementary Figures 1-11, Methods and Materials from Phosphatase PRL-3 Is a Direct Regulatory Target of TGFβ in Colon Cancer Metastasis

Yanjun Jiang Xiaoqiong Liu Ashwani Rajput Liying Geng Melanie Ongchin

Supplementary Figures 1-11, Methods and Materials from Phosphatase PRL-3 Is a Direct Regulatory Target of TGFβ in Colon Cancer Metastasis

10.1158/0008-5472.22387427

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Research on Differentiation Feature of Chinese Geographical Indications Based on Three Departments

Xiaoqiong Liu Zezhou Wu Xiliang Sun Yu Shi Teng Ma

Geographical indications (GIs) are the products formed through the influence of the local natural factors and humanity factors, thus it possesses the original characteristics such as quality and reputation while it is observed as the specified mark of a region.Because of its high quality, great popularity, and strong market competitiveness, GIs play a significant role in promoting the industrialization of the geographical products, improving the international trade of agricultural products, enhancing the development of our national agriculture.In this study, we carefully investigated the different temporal-spatial and type features of Chinese GIs through literature analysis, comparative analysis, and mathematical statistics.We aim to deeply understand the development status and corresponding problems of Chinese GIs, and this research provides a reference for the development of Chinese GIs, provide a resolution of existing agriculture problems, and improve the agricultural internationalization of China.

Feature (linguistics)

10.2991/iceemr-17.2017.102

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