María de la Luz Casas Martínez

Universidad Autónoma de Santo Domingo

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Amparo Vayá

Hospital Universitari i Politècnic La Fe

J Aznar

Leitat Technological Center

Alberto Amor Villalpando

Hospital Central Militar

Luz María Guadalupe Pichardo-García

Universidad Panamericana

Rosa María Sánchez Javier

Universidad Panamericana

Stéphanie Derive

Universidad Panamericana

J. Dalmau

Hospital de Sant Pau

Víctor Manuel Martínez Bullé Goyri

Universidad Nacional Autónoma de México

Manuel Labiós

Hospital Clínico Universitario de Valencia

Antonio Villa

Universidad Nacional Autónoma de México

Cooperative Institutions

Universidad Panamericana

Universidad Nacional Autónoma de México

Hospital Universitari i Politècnic La Fe

Leitat Technological Center

Universidad Panamericana

Instituto de Investigación Sanitaria La Fe

Universitat de València

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Universitat de Barcelona

Bellvitge University Hospital

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BIOTECNOLOGIA GENETICA E INSTRUMENTALIZAÇÂO DA CORPOREIDADE NA VISÂO PÓS-MODERNA DA MEDICINA

Persona y Bioética (2011)

María de la Luz Casas Martínez

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Terminal sedation, euthanasia and bioethics

Revista Cubana de Medicina (2005)

María de la Luz Casas Martínez

Bioethics

Palliative sedation

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Effects of eprosartan on mitochondrial membrane potential and H2O2 levels in leucocytes in hypertension

Journal of Human Hypertension (2008)

Manuel Labiós María de la Luz Casas Martínez Felipe Gabriel Victoria Guiral Sandra Ruiz-Aja

Pathogenesis

Dichlorofluorescein

Olmesartan

10.1038/jhh.2008.19

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Hemorheological Profile In Patients With Cardiovascular Risk Factors

Pathophysiology of Haemostasis and Thrombosis (1996)

Amparo Vayá María de la Luz Casas Martínez J. Dalmau Manuel Labiós Joaquín Aznar

In order to find out whether hemorheological alterations precede the atherosclerotic lesions and could constitute an atherothrombotic risk factor, we studied the hemorheological profile in 150 healthy normotensive offspring whose parents were diagnosed as having essential hypertension WHO I-II grade and in another group of 40 children with familial hypercholesterolemia (FH) but without vascular atherosclerosis lesions, whose parents also suffer from FH. In offspring of hypertensive individuals, a significant increase in the fibrinogen level with respect to the control group was found both in males and females. In addition, only the female offspring showed a higher leucocyte count. FH children showed increased erythrocyte aggregation and increased plasma viscosity with respect to the control group. The fact that the rheological alterations appear prior to the development of the vascular lesion suggests that they could play a role in the pathogenesis of the atherosclerotic process.

10.1159/000217294

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Tanatología y afrontamiento del personal de salud ante la muerte en la pandemia COVID-19

Medicina Paliativa (2021)

María de la Luz Casas Martínez Ignacio Mora Magaña

10.20986/medpal.2021.1257/2021

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Enseñanzas de la pandemia COVID-19. El reencuentro con la vulnerabilidad humana

Bioethics Update (2020)

María de la Luz Casas Martínez

2019-20 coronavirus outbreak

10.1016/j.bioet.2020.09.001

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Treatment of hiliar cholangiocarcinoma (Klatskin’s tumour). Our experience

European Journal of Cancer (1997)

Laura Lladó Jordi Pujol María de la Luz Casas Martínez Juan Figueras A Rafecas

Klatskin tumor

10.1016/s0959-8049(97)86172-2

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Erythrocyte deformability in young familial hypercholesterolemics.

PubMed (1998)

Amparo Vayá María de la Luz Casas Martínez M. Pérez Guillén J. Dalmau J Aznar

In order to ascertain whether young familial hypercholesterolemic subjects without atherosclerotic lesions demonstrable on a carotid echo-Doppler show decreased erythrocyte deformability, we determined the erythrocyte elongation index (EEI) by means of a shear stress diffractometer (Rheodyn SSD) in twenty-four children with heterozygous familial hypercholesterolemia (FH), aged 12 +/- 3 years, and their corresponding affected parent. The parents were twenty-three adults with heterozygous FH aged, 32 +/- 6 years. The control group was made up of a similar number of well matched healthy volunteers. The EEI at 6, 12, 30 and 60 Pa showed no statistical differences between FH children and their control group, or between FH parents and their control group. No correlations were found between EEI and plasma lipids or lipoproteins at any of the shear stresses used. These results suggest that the red blood cells of young familial hypercholesterolemic subjects who show no deterioration of the vascular tree are not less deformable than those of healthy normolipemic subjects, and that dyslipemia itself does not produce alterations that damage the rheological properties of the red blood cell.

Erythrocyte deformability

Erythrocyte aggregation

Color doppler

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Diagnóstico prenatal de la calcinosis arterial idiopática

Progresos de Obstetricia y Ginecología (1999)

E Couceiro C López A Piñón María de la Luz Casas Martínez J Oliver

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Platelet Activation and Red Blood Cell Phosphatidylserine Exposure Evaluated by Flow Cytometry in Patients with Behçet’s Disease: Are They Related to Thrombotic Events?

Pathophysiology of Haemostasis and Thrombosis (2007)

María de la Luz Casas Martínez José M. Ricart Sandra Ruiz-Aja Alma Rus Jose Todolı́

Behçet's disease (BD) is associated with an increased risk of venous and arterial thromboses that are associated with morbidity and mortality increase, although the mechanisms are not well established. In the present study, we used whole blood cytometry to determine the exposure of CD62 on the surface of platelets and the expression of phosphatidylserine (PS) on the surface of circulating red blood cells. Microparticle and microaggregate formation from platelets were also determined in a well-classified group of 72 patients (39 males, 33 females, aged 46.5 +/- 12.5 years) with BD, in comparison with a well-matched control group of 72 healthy volunteers. Results showed no differences in the above-mentioned parameters when BD patients and controls were compared. However, when we compared BD patients with/without thrombosis using these parameters, there were significant differences between both groups. BD patients with previous thrombosis had a higher percentage of circulating CD62-positive platelets and a higher number of circulating microaggregates than those without thrombosis, suggesting that platelet activation may be involved in the development of thrombotic events in these patients.

10.1159/000112635

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Citations (21)

Marí­a de la Luz Casas Martí­nez

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