Rosa Pedrido

Universidade de Santiago de Compostela

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Ana María González Noya

Universidade de Santiago de Compostela

188

M.R. Bermejo

Universidade de Santiago de Compostela

159

Marcelino Maneiro

Universidade de Santiago de Compostela

113

Miguel Martínez‐Calvo

Universidade de Santiago de Compostela

Guillermo Zaragoza

Universidade de Santiago de Compostela

M.J. Romero

National Renewable Energy Laboratory

Sandra Fernández‐Fariña

Universidade de Santiago de Compostela

María J. Romero

Universidade de Santiago de Compostela

Miguel Vázquez López

Universidade de Santiago de Compostela

M.J. Rodríguez

Corporació Sanitària Parc Taulí

Cooperative Institutions

Universidade de Santiago de Compostela

Rede de Química e Tecnologia

Universidade da Coruña

Center for Research in Molecular Medicine and Chronic Diseases

University of the Basque Country

Universidad de las Naciones

Universidad de Burgos

Universidad Internacional

Universitat de Barcelona

Centre National de la Recherche Scientifique

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Efficient Synthesis of Methanesulphonate-Derived Lipid Chains for Attachment of Proteins to Lipid Membranes

Synthetic Communications (2008)

Matthew R. Hicks Atvinder K. Rullay Rosa Pedrido David H. G. Crout Teresa J. T. Pinheiro

We have developed an easy and flexible synthetic methodology to obtain lipid chains containing methanothiosulfonate terminal groups with the aim to attach them to natural proteins as functional groups. There are many proteins found in nature that are modified by lipids, and this is a key part of their function. For example, the prion protein is attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor, and this protein is thought to be the causative agent in diseases such as bovine spongiform encephalopathy (BSE; “mad cow disease”) and the human equivalent Creutzfeldt–Jakob disease. However, production of large amounts of protein in bacteria results in proteins that lack these lipid modifications. The lipid chains containing methanothiosulfonate terminal groups that we have synthesized here can be attached to these proteins through the thiol contained in the side chain of the cysteine residue, which can be incorporated into the protein sequence at the desired position.

Residue (chemistry)

Side chain

Thiol

10.1080/00397910802213794

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Citations (6)

A UTILIDADE DOS PUNTOS CUÁNTICOS

Boletín das Ciencias (2020)

M.R. Bermejo Ana María González Noya Marcelino Maneiro Rosa Pedrido

Neste artigo temos como obxectivo dar a coñecer como é o mundo dun tipo de nanomateriais metálicos chamados Puntos Cuánticos (PCs) ou, en terminoloxía inglesa, os Quantum Dots (QDs). A pretensión deste traballo é a de estudar que se entende hoxe por Puntos Cuánticos, como é a súa constitución, cal é o seu tamaño e forma; de que tipo resulta ser o seu enlace, como consecuencia do seu confinamento cuántico; cal é o efecto da luz sobre o tamaño e a natureza destes novos materiais; como son os métodos de obtención hoxe e como podemos caracterizar estes novos materiais; como son as súas propiedades e por ende as súas interesantes aplicacións como consecuencia da súa constitución; cal é a importancia actual das súas aplicacións tanto na industria dos sensores químicos modernos, como sondas fluorescentes, como na farmacoloxía; como se realiza a bioconxugación destes materiais para a detección (diagnose) de tumores malignos e, posiblemente, para a súa utilización na terapia do cancro.

10.54954/202089011

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Citations (1)

CCDC 1526887: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

María J. Romero Vanesa Suárez Sandra Fernández‐Fariña Marcelino Maneiro Emilio Martı́nez-Núñez

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1n7vf5

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Citations (0)

CCDC 203518: Experimental Crystal Structure Determination

The Cambridge Structural Database (2003)

Rosa Pedrido M.R. Bermejo Ana M. Garcı́a-Deibe Ana María González Noya Marcelino Maneiro

10.5517/cc6ts3w

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CCDC 740290: Experimental Crystal Structure Determination

The Cambridge Structural Database (2010)

A. Castiñeiras Rosa Pedrido

10.5517/ccsvbb8

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CCDC 713941: Experimental Crystal Structure Determination

The Cambridge Structural Database (2010)

A. Castiñeiras Rosa Pedrido

10.5517/ccryxcy

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Citations (0)

CCDC 2181452: Experimental Crystal Structure Determination

The Cambridge Structural Database (2022)

Sandra Fernández‐Fariña Miguel Martínez‐Calvo Marcelino Maneiro José M. Seco Guillermo Zaragoza

10.5517/ccdc.csd.cc2c6zf0

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Monohelical Metal Complexes of a Bis-Bidentate Schiff Base with a Short Rigid Spacer. The Spontaneous Resolution of P-[Ni(FTs)]·CH3CNDedicated to Professor Joachim Strähle in the Occasion of his 65th Birthday

Zeitschrift für anorganische und allgemeine Chemie (2002)

Miguel Vázquez López M.R. Bermejo Matilde Fondo Ana M. Garcı́a-Deibe Ana María González Noya

The electrochemical reaction of the bis-bidentate Schiff base H2FTs [N, N′-bis(2-tosylaminobenzylidene)-1, 2-diaminobencene] with cobalt, nickel, copper, zinc and cadmium, lead to the isolation of neutral [M(FTs)] complexes. All of them were characterized by elemental analyses, mass spectrometry, IR and 1H NMR spectroscopy and magnetic measurements, where appropriate. Recrystallization of the nickel complex yields single crystals of [Ni(FTs)]·CH3CN (1). The x-ray characterization shows a distorted square-planar environment for the nickel atom, with the Schiff base acting as a tetradentate N4 donor. Complex 1 can be described as a mononuclear single-stranded helical compound, with spontaneous resolution of the P enantiomer upon crystallisation. Monohelikale Metallkomplexe einer bis-zweizähnigen Schiff schen Base mit kurzen Abstandshaltern. Spontane Enantiomerentrennung von P-[Ni(FTs)] · CH3CN Die elektrochemische Reaktion der bis-zweizähnigen Schiff'schen Base H2FTs [N, N′-bis(2-tosylaminobenzyliden)-1, 2-Diaminbenzol] mit Cobalt, Nickel, Kupfer, Zink und Cadmium führt zu den neutralen Komplexen [M(FTs)]. Alle Verbindungen, so weit möglich, wurden durch Elementaranalysen, Massenspektren, IR- und 1H-NMR Spektren charakterisiert. Umkristallisation des Nickelkomplexes ergibt Einkristalle von [Ni(FTs)]·CH3CN (1). Die röntgenographische Charakterisierung zeigt verzerrt-quadratisch-planare Koordination für das Nickelatom mit der Schiff'schen Base als vierzähnigen N4-Donator. 1 kann als einsträngige, helikale Verbindung beschrieben werden mit spontaner Enantiomerentrennung bei der Kristallisation.

10.1002/1521-3749(200206)628:5<1068::aid-zaac1068>3.0.co;2-6

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Citations (14)

CCDC 675723: Experimental Crystal Structure Determination

The Cambridge Structural Database (2008)

A. Castiñeiras Rosa Pedrido

10.5517/ccqp4j1

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Novel Fluorescent Cationic Silver Thiosemicarbazone Clusters Containing Different Eight-Membered Ag₄S₄ Metallacycles

Inorganic Chemistry (2009)

A. Castiñeiras Rosa Pedrido

The reaction of silver acetate and silver nitrate with the new phosphinethiosemicarbazone ligand 2-(2-(diphenylphosphino)benzylidene)-N-ethylthiosemicarbazone (HLPEt) gave rise to the complexes [Ag(LPEt)](4).2MeOH (1) and [Ag(2)(LPEt)(HLPEt)](2).(NO(3))(2) (3). Slow crystallization of the mother liquors obtained from the synthesis of 1 and 3 afforded suitable crystals of [Ag(2)(LPEt)(HLPEt)](2)(CH(3)COO)(2).6MeOH (2) and [Ag(2)(LPEt)(HLPEt)](2)(NO(3))(2).2MeOH.2H(2)O (4), respectively. Complexes 2 and 4 are tetranuclear silver clusters displaying a similar Ag(4)S(4)P(4) core, but containing different sizes, conformations for the Ag(4)S(4) metallacycles, and crystal packings. The four complexes are strongly luminescent in methanol solutions. A comparison between the emission bands of compounds 1-4 lead us to conclude that the luminescence is notably affected by the charge and the counterion of the cluster.

Cationic polymerization

Semicarbazone

Silver nitrate

10.1021/ic900062y

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Citations (30)