Mohammed Aref

Zagazig University

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Nanees F. El-Malkey

Zagazig University

Magda H. El‐Badramany

Jahra Hospital

Ameer E Hassan

Valley Baptist Medical Center

Arnd Dörfler

Universitätsklinikum Erlangen

Dmitry Skrypnik

City Clinical Hospital

Alan Reeves

University of Kansas Medical Center

David Dornbos

University of Kentucky

Mariano Espinosa de Rueda Ruíz

Hospital Universitario Virgen de la Arrixaca

Keith Woodward

Fort Sanders Regional Medical Center

Raphaël Blanc

Fondation de Rothschild

Cooperative Institutions

Neurological Surgery

Health and Education Research Management and Epidemiologic Services (United States)

Universitätsklinikum Erlangen

Friedrich-Alexander-Universität Erlangen-Nürnberg

Zagazig University

Boston University

Neurology, Inc

Vall d'Hebron Hospital Universitari

Medical University of Lublin

Vall d'Hebron Institut de Recerca

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Endovascular Treatment of Acute Ischemic Stroke With the Penumbra System in Routine Practice: COMPLETE Registry Results

Stroke (2021)

Osama O. Zaidat Johanna T Fifi Ashish Nanda Benjamin Atchie Keith Woodward

The purpose of the COMPLETE (International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Revascularization Device) registry was to evaluate the generalizability of the safety and efficacy of the Penumbra System (Penumbra, Inc, Alameda) in a real-world setting.COMPLETE was a global, prospective, postmarket, multicenter registry. Patients with large vessel occlusion-acute ischemic stroke who underwent mechanical thrombectomy using the Penumbra System with or without the 3D Revascularization Device as frontline approach were enrolled at 42 centers (29 United States, 13 Europe) from July 2018 to October 2019. Primary efficacy end points were successful postprocedure angiographic revascularization (modified Thrombolysis in Cerebral Infarction ≥2b) and 90-day functional outcome (modified Rankin Scale score 0-2). The primary safety end point was 90-day all-cause mortality. An imaging core lab determined modified Thrombolysis in Cerebral Infarction scores, Alberta Stroke Program Early CT Scores, clot location, and occurrence of intracranial hemorrhage at 24 hours. Independent medical reviewers adjudicated safety end points.Six hundred fifty patients were enrolled (median age 70 years, 54.0% female, 49.2% given intravenous recombinant tissue-type plasminogen activator before thrombectomy). Rate of modified Thrombolysis in Cerebral Infarction 2b to 3 postprocedure was 87.8% (95% CI, 85.3%-90.4%). First pass and postprocedure rates of modified Thrombolysis in Cerebral Infarction 2c to 3 were 41.5% and 66.2%, respectively. At 90 days, 55.8% (95% CI, 51.9%-59.7%) had modified Rankin Scale score 0 to 2, and all-cause mortality was 15.5% (95% CI, 12.8%-18.3%).Using Penumbra System for frontline mechanical thrombectomy treatment of patients with large vessel occlusion-acute ischemic stroke in a real-world setting was associated with angiographic, clinical, and safety outcomes that were comparable to prior randomized clinical trials with stringent site and operator selection criteria. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03464565.

Penumbra

Stroke

TIMI

10.1161/strokeaha.121.034268

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Citations (23)

Omentin -1 antagonizes high fat-induced bone loss in rats and promotes bone growth via AMPK/mTORC1/ PPAR-γ and GDF-11 signaling pathway

Zagazig University Medical Journal (2023)

Nanees F. El-Malkey Nisreen Elwany Nehal Goda Mohammed Aref Sama Khalil

Background: Obesity induces bone related diseases as a consequence of reduced bone formation and unwarranted bone resorption.Therefore, the possible impact of adipokines on osteogenesis has been considered.Nevertheless, the osteogenic properties of omentin-1 are indistinct and contentious.The objective of the current work was to determine the regulatory effects of omentin-1 on bone turnover, along with exploring the fundamental molecular mechanisms in obese rats.Methods: The present study investigated the effects of intraperitoneal omentin-1 injection (8 μg/kg, once daily, for 14 days) in rats after feeding a high-fat diet for 10 weeks to induce obesity.Metabolic parameters and bone dry and ash weights were measured; serum calcium, phosphorus, alkaline phosphatase, and growth differentiation factor-11 (GDF-11), and femur histopathological changes were analyzed.Additionally, we investigated the effect of omentin-1 treatment on AMP protein-kinase (AMPK), mammalian target rapamycin (mTORC1) and nuclear receptor peroxisome proliferator-activated receptor-γ (PPAR-γ) expression.Results: The results revealed significant improvement in metabolic, bone biochemical parameters and histopathological changes in the omentin-1 treated group with a significant increase in area % of bone.A significant down-regulation of mTORC1 was identified through AMPK/mTORC1/PPAR-γ pathway accompanied by an increase in serum GDF-11.Conclusions: Omentin-1 can significantly promote bone health and viability via down-regulation of the AMPK/mTORC1/PPAR-γ signaling pathway and up-regulation of serum GDF-11, thus it can promote bone formation and prevent osteoporosis.

10.21608/zumj.2023.205450.2788

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The Dexamethasone Suppression Test in Depressed Kuwaiti Patients

The British Journal of Psychiatry (1988)

Mohammed Aref Magda H. El‐Badramany Sosamma John Mamoun Al-Awqati Ahmed Malalla Al-Ansari

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Dexamethasone suppression test

Content (measure theory)

10.1192/bjp.152.1.144b

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Citations (2)

Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia

Reproductive Sciences (2021)

Nanees F. El-Malkey Mohammed Aref Hassan Emam Sama S. Khalil

Malondialdehyde

10.1007/s43032-021-00497-3

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Citations (8)

Progestins Protocols For Inducing Estrus Synchronization In Breeding Season In Ossimi Sheep.

Alexandria Journal of Veterinary Sciences (2016)

Ahmed Ahmed Nasra Yousef A. I. Mahmoud Mohammed Aref

Estrus synchronization

10.5455/ajvs.245197

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Citations (5)

Sleep deprivation disturbs uterine contractility and structure in pregnant rats: role of matrix metalloproteinase 9 and transforming growth factor-β

Canadian Journal of Physiology and Pharmacology (2023)

Nanees F. El-Malkey Mohammed Aref Nehal I. A. Goda Marwa Hussien Walaa Samy

Sleep deprivation (SD) during pregnancy can impact the delivery procedure, with prolongation of the labor duration. Matrix metalloproteinase-9 (MMP9) and transforming growth factor-β (TGF-β) are regulators of uterine remodeling. Their dysregulation is vital for abnormal placentation and uterine enlargement in complicated pregnancies. Therefore, this study aims to explore the outcome of SD throughout pregnancy on ex vivo uterine contractility, MMP9 and TGF-β, and uterine microscopic structure. A total of 24 pregnant rats were divided into two groups. From the first day of pregnancy, animals were exposed to partial SD/6 h/day. Uterine in vitro contractile responses to oxytocin, acetylcholine, and nifedipine were assessed. Additionally, uterine levels of superoxide dismutase and malondialdehyde and uterine mRNA expression of MMP9, TGF-β, and apoptotic biomarkers were analyzed. The results showed that SD significantly reduced uterine contractile responses to oxytocin and acetylcholine, while it augmented the relaxing effect of nifedipine. In addition, it significantly increased oxidative stress status, MMP9, TGF-β, and apoptotic biomarkers' mRNA expression. All were accompanied by degeneration of endometrial glands, vacuolization with apoptotic nuclei, and increased area% of collagen fibers. Finally, increased uterine MMP9 and TGF-β mRNA expression during SD clarified their potential role in modulating uterine contractility and structure.

MMP9

Contractility

Myometrium

10.1139/cjpp-2023-0120

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Erotomania in an Arab

The British Journal of Psychiatry (1986)

Magda H. El‐Badramany Mohammed Aref

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Content (measure theory)

10.1192/bjp.148.1.106b

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