Filiz Canpolat

Memorial Ankara Hospital

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BÇ

Bengü Çevirgen Cemil

Sağlık Bilimleri Üniversitesi

Fatma Eskioğlu

Sağlık Bilimleri Üniversitesi

Müzeyyen Gönül

Ministry of Health

Murat Alper

University of Health Sciences

Hatice Ataş

Memorial Ankara Hospital

Havva Kaya Akış

Ministry of Health

Selda Pelin Kartal

Memorial Ankara Hospital

Gökçe Işıl Kurmuş

Memorial Ankara Hospital

Murat Oktay

Istanbul Memorial Hospital

Demet Yılmazer

Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi

Cooperative Institutions

Sağlık Bilimleri Üniversitesi

Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi

Ministry of Health

University of Health Science

University of Health Sciences Antigua

Memorial Ankara Hospital

Gazi University

Psychiatric Association of Turkey

Hacettepe University

University of Health Sciences

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Eritroblastozis Fetalise Bağli Blueberry Muffin Bulgusu

Yeni Tıp Dergisi (2010)

Filiz Canpolat Fuat Emre Canpolat Hasan Tezer Fatma Esk O Lu

ABSTRACT Blueberry Muffin sign due to erythroblastosis fetalis Blueberry muffin sign is a cutaneous manifestation characterized by widespread reddish-blue maculopapular lesions. The eruptions are often generalized but favor the trunk, head, and neck. Blueberry muffin skin lesions are manifestations of dermal haematopoiesis and are associated with both intra-uterine infections and hematological disorders with chronic and severe anaemia. TORCH (toxoplasmosis, rubella, cytomegalo-virus, herpes simplex) group infections, hemolytic disease of the newborn (ABO and Rh incompatibility) and hereditary spherocytosis are well-known causes for blueberry muffin sign. The differential diagnosis includes congenital neoplastic disorders and vascular lesions. Herein, a case of blueberry muffin sign in a newborn baby due to erythroblastosis fetalis is reported and it has been emphasized that blueberry muffin sign should be taken into consideration in the differential diagnosis of blue-red maculopapular lesions in newborns.

Maculopapular rash

Congenital Rubella

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Hand Foot Skin Reaction Associated with Sunitinib

Turkish Journal of Dermatology (2015)

Bengü Çevirgen Cemil Havva Kaya Akış Filiz Canpolat Müzeyyen Gönül Seda Atay

Sunitinib renal hücreli karsinom ve gastrointestinal stromal tümörlü hastalarda yarar gösteren bir multikinaz inhibitörüdür.Sunitinib pek çok kutanöz toksisiteye yol açmaktadır.El ayak deri reaksiyonu en karakteristik ve en sık görülen kutanöz toksisitedir.Lezyonlar iyi sınırlı, özellikle basınç alanlarına lokalize ve çevresi eritem ile sınırlı sarı, ağrılı kallus benzeri hiperkeratoz ile karakterizedir.Elli dört yaşında erkek hasta renal hücreli karsinom nedeniyle başlanan 50 mg/gün oral sunitinib tedavisinin

Foot (prosody)

Skin reaction

10.4274/tdd.1949

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Citations (1)

Serotonin Expression in Lichen Planus Lesions and Its Relationship with Depression/Anxiety

Annals of Dermatology (2019)

Gökçe Işıl Kurmuş Müzeyyen Gönül Filiz Canpolat Demet Yılmazer Eylem Şahin Cankurtaran

Psychological factors such as stress, depression, and anxiety have been documented to contribute to the development of lesions in lichen planus (LP).To evaluate the relationship between serotonin expression in LP lesions and depression/anxiety.Forty patients (22 females, 18 males) with LP and 20 healthy control subjects were included in this study. The severity of LP was assessed with the palmar method (using the measurement of affected body surface area [BSA]). The depression and anxiety scores were measured with Beck's depression inventory (BDI) and Beck's anxiety inventory (BAI). The expression of serotonin was determined via immunohistochemistry in LP lesions and in the control group skin using a monoclonal antibody to serotonin.The skin biopsies of the LP patients had significantly higher levels of serotonin than those of the control subjects (p<0.001). In the LP patients, and there was a positive correlation between serotonin expression and LP severity (p=0.022). Based on the results from the BDI and BAI, there was a significant relationship between the severity of depression/anxiety and intensity of serotonin expression (p<0.001).Data from this study suggest that serotonin may have a possible role in the pathogenesis of LP. Further, the relationship between serotonin expression in acute cutaneous lesions and the depression/anxiety scores indicates that serotonin may be a mediator for the association of LP and depression/anxiety simultaneously. There is a need for more specific studies showing the expression of serotonin in the lichen planus to demonstrate the cause or effect.

Depression

Pathogenesis

10.5021/ad.2019.31.2.146

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Citations (7)

1822 Effect of Needle Length for Response to Hepatitis B Vaccine in Macrosomicneonates: A Prospective Randomized Study

Archives of Disease in Childhood (2012)

Рамазан Оздемир Filiz Canpolat Sadık Yurttutan Mustafa Öncel Ömer Erdeve

Background and Aims

The objective of this study was to determine whether use of a longer (1 in.) rather than astandard (5/8 in.) needle used for macrosomic neonates (birthweight over 4000 g) may affect antibodytiters after immunization against hepatitis B virus (HBV).

Methods

Fifty nine healthy infants were vaccinated at birth, 1, and 6 months of age with hepatitis Bvaccine, with follow up to 7 months of age. Infants were randomized into two groups according to needlelength of first vaccine at birth. First group vaccinated with standart needle length and other group receivedvaccine by longer needle length.

Results

Macrosomic infants who were immunized with a longer needle achieved significantly higher antibodytiters to hepatitis B surface antigen than standart needle length (median, 3890.2 vs 1311.7 mIU/mL, respectively; p=0.001).

Conclusions

Macrosomic neonates benefit from longer needle length with higher levels of antibody titersafter HBV vaccination.

Hepatitis B vaccine

Hepatitis B

10.1136/archdischild-2012-302724.1822

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Bullous Mastocytosis in an Infant

Journal of the Turkish Academy of Dermatology (2011)

Filiz Canpolat

Observation:We report on a 9-month-old male infant with multiple tense bullae, erosions and hemorrhagic crusts on the scalp, face and distal lower limb.He had generalised yellowish thick and rough skin, giving doughy feel and 'peau d' orange' appearance of the skin at places.The histopathological examination revealed a dense dermal cellular infiltrate identified as mast cells by toluidine blue stain.The direct immunofluorescence was negative.A diagnosis of diffuse cutaneous mastocytosis (DCM) with generalized bullae was made based on these clinical and histopathological findings.In cases with DCM with generalized bullae, systemic involvement is more frequent and more severe compared to other types of cutaneous mastocytosis.Some lethal outcomes have been reported.Therefore, proper follow-up with evaluations for systemic involvement is required for these patients.

10.6003/jtad.1261c3

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A case of subcorneal pustular dermatosis in association with monoclonal IgA gammopathy successfully treated with acitretin

Journal of Dermatological Treatment (2010)

Filiz Canpolat Hatice Akpınar Bengü Çevirgen Cemil Fatma Eskioğlu Evrim Öztürk

Subcorneal pustular dermatosis (SPD), or Sneddon–Wilkinson disease, is a rare, chronic, recurrent, pustular eruption. Association with several diseases is well known, mainly IgA and IgG gammopathies or myelomas. Although dapsone is often considered to be the first-line treatment, some patients fail to respond or cannot tolerate the side effects. For cases that do not respond well to this treatment, acitretin, an excellent second-line treatment, may be used. Herein, a 55-year-old woman with SPD associated with monoclonal IgA gammopathy refractory to dapsone is presented, who was successfully treated with acitretin in a short period.

Acitretin

Monoclonal gammopathy

Gammopathy

Paraproteinemias

10.3109/09546630902882071

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Citations (16)

Darier Hastalığı ile Bipolar Afektif Bozukluk Birlikteliği

Turkiye Klinikleri Journal of Dermatology (2009)

Filiz Canpolat Bengü Çevirgen Cemil Fatma Eskioğlu Murat Oktay Murat Alper

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Reduced erythrocyte deformability in active and untreated Behçet’s disease patients

International Journal of Dermatology (2010)

Semih Tatlıcan Fatma Duran Cemile Eren Fatma Eskioğlu Neslihan Dikmenoğlu

Abstract Objective Although the etiology of Behcet’s disease is not clarified yet, the vascular endothelial damage and thrombosis are prominent features of the disease. The underlying mechanisms of increased risk of thrombosis in Behcet’s disease are not completely understood. It is stated that the changes in blood rheology such as erythrocyte deformability take part in the thrombosis. There are limited numbers of studies with conflicting results about the erythrocyte deformability in Behcet’s disease. The previous studies were not limited to the untreated patients with active disease. Method Blood samples were filtered immediately by “Imugard‐ leukocyte removal filter”. After plasma and erythrocytes were separated by centrifugation, 10% erythrocyte suspensions were prepared with isotonic Tris NaCl buffer solution. These erythrocyte suspensions were filtered under gravitational force by “Nucleopore” to determine the filtration time. The filtration times of the erythrocyte and buffer solutions were referred as t1 and t2 respectively. Finally, deformability indices were obtained by dividing the t1 by t2. A decrease in the deformability of the erythrocytes would result in an increase in the filtration time of the erythrocyte suspension and deformability indices. Results The median deformability indices were 3.090 and 2.170 for patients and control subjects respectively and the difference was statistically significant (P = 0.000). Conclusion We suggest that the decrease in erythrocyte deformability in Behcet’s disease may be related to oxidative damage of erythrocytes and subsequently takes part in the development of thrombosis in Behcet’s disease.

Erythrocyte deformability

Etiology

Erythrocyte aggregation

Filtration (mathematics)

Erythrocyte sedimentation rate

10.1111/j.1365-4632.2009.04229.x

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Citations (8)

Hydrocortisone acetate alone or combined with mupirocin for atopic dermatitis in infants under two years of age - a randomized double blind pilot trial.

PubMed (2012)

Filiz Canpolat Mustafa Erkoçoğlu Hakan Tezer Can Naci Kocabaş Başak Kandi

The skin of patients with atopic dermatitis (AD) is heavily colonized with Staphylococcus (S.) aureus, even at uninvolved sites. Toxins secreted by the majority of S. aureus on the skin behave as superantigens and can directly influence the disease activity, although clinical signs of bacterial superinfection might be absent.This study was conducted to compare the efficacy of hydrocortisone cream, combined with mupirocin or alone with emmolient ointment for the treatment of mild to moderate AD in infants between six months and two years of age.A total of 83 patients with mild to moderate AD were randomized to receive hydrocortisone, hydrocortisone+ mupirocin or emmolient ointment twice daily in one week and followed-up for 8 weeks, in a blind study. Efficacy evaluation made by SCORAD and eczema area and severity index (EASI) at baseline, day 7, and weeks 2, 4, and 8. Possible adverse events were recorded to evaluate safety.At the end of study, 65% (17 of 26) of the patients were treated successfully with hydrocortisone ointment based on SCORAD and EASI scores. Also there was a significant improvement in patients combined with mupirocin ointment [74% (20 of 27)]. The percent improvement from baseline in EASI scores was also significantly greater in hydrocortisone and combined group compared with emmolient-treated patients (36%) (p = 0.0187, p = 0.012 respectively).Monotherapy with hydrocortisone ointment is the main treatment in infants with mild to moderate AD and combination with mupirocin is safe and effective often needed because of possible Staphylococcus carriage.

Mupirocin

SCORAD

Erythema

Hydrocortisone acetate

Superinfection

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Citations (23)

Sistemik isotretinoin kullanımının ses üzerindeki etkisi

Kulak burun boğaz ihtisas dergisi : (2017)

Mustafa Şahin Emel Çadallı Tatar Filiz Canpolat Gökçe Yildirim Aksoy Mehmet Korkmaz

Isotretinoin

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